Sphenocentrum jollyanum Pierre (Menispermaceae): From traditional medicine to pharmacological activity and chemical constituents

Subject Areas : Ethnopharmacology

Idayat Akinwumi ¹ , Mubo Sonibare ²

1 - Department of Pharmacognosy, Faculty of Pharmacy, Lead City University, Ibadan, Nigeria
2 - Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria

Received: 2022-07-14 Accepted : 2022-12-20 Published : 2022-12-01

Keywords: Pinnatasterone, Phytochemistry, Bioactivity, <i>Sphenocentrum jollyanum</i> Pierre, Medicinal Plants, Menispermaceae, Columbin,

Abstract :

In Yoruba, southwestern Nigeria, Sphenocentrum jollyanum Pierre is known as “Akerejupon”. S. jollyanum is commonly used in traditional medicine to treat a variety of ailments because of its diverse biological activities. However, a thorough examination of the traditional, pharmacological, and phytochemical properties of S. jollyanum is yet lacking. Different plant organs are used as aphrodisiacs, treatments for chronic illnesses including coughs and ulcers, and for malaria by traditional medicinal practitioners. The pharmacological activities of this plant include anti-diabetic, antioxidant, hepatoprotective, anti-inflammatory, antimalarial, anti-allergy, antimicrobial, among others. Some of the isolated compounds from this plant are columbin, isocolumbin, fibleucin, atrotosterone A, pinnatasterone, polypodine B, and 20-hydroxyecdysone. In order to explore this plant for further research and to know its potential effect towards pharmaceutics, the present review aims to provide an updated summary of documents sourced from recent publications regarding ethnomedicinal uses, pharmacology, and phytochemistry of S. jollyanum.

References:

Abiodun, B.A., Adewale, A., Abiodun, O.O., 2017. Phytochemical and proximate analysis of some medicinal leaves. Clin. Med. Res. 6(6), 209-214.
Aboaba, S.A., Ekundayo, O., 2010. Constituents, antibacterial activities and toxicological assay of essential oils of Artocarpus communis Forst (Moraceae) and Sphenocentrum jollyanum (Menispermaceae). Int. J. Biol. Chem. Sci. 4, 1455-1461.
Achenbach, H., Hemrich, H., 1991. Clerodane-type diterpenes and other constituents of Penianthus zenkeri. Phytochemistry 30, 1957-1962. 
Adeleke, O., Oboh, G., Adefegha, S., Osesusi, A., 2022. Effects of aqueous extract of the root and leaf of red medicine (Sphenocentrum jollyanum Pierre) on wounds of diabetic rats: Influence on wound tissue cytokines, vascular endothelial growth factor and microbes. J. Ethnopharmacol. 293,115266. doi: 10.1016/j.jep.2022.115266.
Agomuo, E.N., Uchenna, A.P., 2018. Nutrient and antioxidant properties of oils from bagasses, agricultural residues, medicinal plants and fodders. J. Am. Coll. Nutr., doi: org/10.1080/07315724.2018.1484307.
Ajao, A.A., Sibiya, N.P., Moteetee, A.N., 2019. Sexual prowess from nature: A systematic review of medicinal plantsused as aphrodisiacs and sexual dysfunction in sub-Saharan Africa. S. Afr. J. Bot. 122, 342-359.
Ajayi, T.O., Srivedavyasasri, R., Nyong, E.E., Odeniyi, M.A., Moody, J.O., Ross, S.A., 2019. Two new phytoecdysteroids from Sphenocentrum jollyanum Pierre root. Steroids 156, 108456. https://doi.org/10.1016/j.steroids. 2019.108456.
Akinwumi, I.A., Sonibare, M.A., Salami, A.T., 2022. Gastroprotective Effect of Methanol extract of Sphenocentrum jollyanum Pierre and Curculigo pilosa (Schumach. & Thonn.) Engl. in Wistar rats. Trop. J. Nat. Prod. Res. 6(4), 637-644.
Akinwumi, I.A., Sonibare, M.A., Yeye, E.O., Khan, M., 2020. Bioassay-guided isolation and identification of anti-ulcer ecdysteroids from the seeds of Sphenocentrum jollyanum Pierre (Menispermaceae). Steroids 159, 108636. 
Akinwumi, I.A., Sonibare, M.A., 2019. Use of medicinal plants for the treatment of gastric ulcerin some parts of Southwestern Nigeria. Afri. J. Pharm. Pharmacol. 13(15), 223-235.
Geberemeskel, G.A., Debebe Y.G., Nguse, N.A., 2019. Anti-diabetic effect of Fenugreek seed powder solution (Trigonella foenum-graecum L.) on hyperlipidemia in diabetic patients. J. Diabetes Res. 8507453. 
Alese, M.O., Adewole, O.S., Ijomone, O.M., Ajayi, S.A., Alese, O.O., 2014. Hypoglycemic and hypolipidemic activities of methanolic extract of Sphenocentrum jollyanum on streptozotocin-induced diabetic Wistar rats. European J. Med. Plants 4(3), 353-364.
Al-Snafi, A.E., Mousa, H.N., Majid, W.J., 2019. Medicinal plants possessed hepatoprotective activity. IOSR J. Pharm. 9(8), 26-56.
Amidu, N., Woode, E., Owiredu, K.B.A.W., Asare, A.G., Boateng, A.K., Opoku-Okrah, C., 2008. An evaluation of toxicity and mutagenicity of Sphenocentrum jollyanum. Int. J. Pharmacol. 4(2), 67-77.
Angelini, P., Pagiotti, R., Granetti, B., 2008. Effect of antimicrobial activity of Melaleuca alternifolia essential oil on antagonistic potential of Pleurotusspp. against Trichoderma harzianumin dual culture. World J. Microbiol. Biotechnol. 24, 197-202.
Anyanwu, M.U., Okoye, R.C., 2017. Antimicrobial activity of Nigerian medicinal plants. J. Intercult. Ethnopharmacol. 6(2), 240-259.
Baffoe, M., Koffuor, G., Baffour-Awuah, A., Sallah, L., 2021. Assessment of reproductive toxicity of hydroethanolic root extracts of Caesalpinia benthamiana, Sphenocentrum jollyanum, and Paullinia pinnata. J. Exp. Pharmacol. 13, 223-234.
Brusotti, G., Cesari, B., Dentamaro, G., Caccialanza, A., Massolini, G., 2014. Isolation and characterization of bioactive compounds from plant resources: The role of analysis in the ethnopharmacological approach. J. Pharm. Biomed. Anal. 87, 218-228.
Budesinsky, M., Vokac, K., Harmatha, J., Cvacka, J., 2001. Additional minor ecdysteroid components of Leuzea carthamoides. Steroids 73, 502-514.
Burkill, H.M., 1995. The Useful Plants of West Tropical Africa. 2nd Ed., Vol. 1, Families A-D. Royal Botanic Gardens, Kew, Richmond, United Kingdom. pp. 21-25.
Che, C.T., George, V., Ijinu, T.P., Pushpangadan, P., Andrae-Marobela, K., 2017. Traditional medicine. Pharmacogn. 101. doi: org/10.1016/B978-0-12-802104-0.00002-0.
Csikos, E., Horvath, A., Acs, K., Papp, N., Balazs, V.L., Dolenc, M.S., Kenda, M., Kocevar, G.N., Nagy, M., Protti, M., 2021. Treatment of benign prostatic hyperplasia by natural drugs. Molecules 26, 7141.
Ekpono, E.U., Aja, P.M., Ugwu, O.P.C., Udeozor, P.A., Clementina, U.U., Nweke, O.L., 2018. Phytochemical and proximate analysis of Sphenocentrum jollyanum ethanol root extract and dry sample collected from Ebonyi State, Nigeria. IDOSR J. Biol. Chem. Pharm. 2(1), 8-17.
Elozia, N., Kumar, N., Preeti, K., Purabi, D., Bipin, K.N., 2017. A review on antidepressants Plants. J. Pharm. Res. 11(5), 382-396.
Enenebeaku, U.E., Okotcha, E.N., Oguoma, L.M.O., 2021. Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandraarborescens (Welw.). Bull. Natl. Res. Cent. 45,186.
Fadahunsi, O.S., Olorunnisola, O.S., Owoade, O., 2018. In-vitro anti-inflammatory activities of extract of the leaves of Sphenocentrum jollyanum Pierre. J. Appl. Life Sci. Int. 18(4), 1-9.
Frezza, C.,Venditti, A., Serafini, M., Bianco, A., 2019. Phytochemistry, chemotaxonomy, ethnopharmacology, and nutraceutics of Lamiaceae. Stud. Nat. Prod. Chem. 62, 125-178.
Gnagbe, A., 2018. Sphenocentrum jollyanum Pierre. World Flora. www.plantnet.com.au.
Ghribia, L., Ghouilaa, H., Omrib, A., Besbesb, M., Janneta, H.B. 2014. Antioxidant and anti-acetylcholinesterase activities of extracts and secondary metabolites from Acacia cyanophylla. Asian Pac. J. Trop. Biomed. 4, 417-423.
Hossain, A., Hossain, A., Mannan, S.J., 2019. Evaluation of antioxidant and analgesic activities of three medicinal plants. Pharmacogn. Res. 11, 248-255.
Iwu, M.M. 1993. Handbook of African Medicinal Plants; CRC Press: Boca Raton, FL, USA, p. 239.
Koleosho, A.T., Jose, A.R., Oyibo, P.G., Roland-Ayodele, M.A., Uloko, M.E., 2013. Antimicrobial activity of Sphenocentrum jollyanum and Mangifera indica Linn. on Salmonella typhi. J. Pharm. Biol. Sci. 5(3), 50-54.
Li, R., Morris-Natschke, S., Lee, K.H., 2016. Clerodane diterpenes: sources, structures and biological activities. Nat. Prod. Rep. 33(10), 1166.
Lorke, D., 1983. A new approach to practical acute toxicity testing. Arch. Toxicol. 54(4), 275-287. 
Magalhaesa, P.K.A., Araujoa, E.N., Santosa, A.M., Vanderleic, M.B., Souzaa, C.C.L., Correiaad, M.S., Fonsecaa, S.A., Pavãoa, J.M.J.S., Souzaa, M.A., Costaa, J.G., Santos, A.F., Matos-Rocha, T.J., 2022. An ethnopharmacological study of medicinal plants used by a traditional community in Brazil’s northeastern. Braz. J. Biol. 82, 1-11. doi: org/10.1590/1519-6984.237642.
Mahomoodally, M.F., 2013. Traditional medicines in Africa: An appraisal of ten potent African medicinal plants. Special issue on recent advances towards validating efficacy and safety of African traditional medicines. Evid. based Complement. Alternative Med. 1-14.
Mambu, L., Ramanandraibe, V., Martin, M.T., Blond, A., Grellier, P., Frappier, F., 2002. Constituents of Burasaia madagascariensis: a new clerodane-type diterpene. Planta Med. 68, 377-379.
Mbaka, G., Ogbonnia, S., Sulaiman, A., Osiagwu, D., 2019. Histomorphological effects of the oil extract of Sphenocentrum jollyanum seed on benign prostatic hyperplasia induced by exogenous testosterone and estradiol in adult Wistar rats. Avicenna J. Phytomed. 9(1), 21-33. 
Mbaka, G.O., Adeyemi, O.O., Oremosu, A.A., 2010. Acute and sub-chronic toxicity studies of the ethanol extract of the leaves of Sphenocentrum jollyanum (Menispermaceae). Agric. Biol. J. North Amer. 1, 265-272.
Modro, A.F.H., Meneguelli, A.Z., Ribeiro, S.B., Maia, E., Lima-Júrnior, G.A., 2015. Importânciado conhecimentotradicional de plantasmedicinais para a conservação da Amazônia. In: Resumos do IX Congresso Brasileiro de Agroecologia, Belém, PA. Rio de Janeiro: Associação Brasileira de Agroecologia. Cadernos de Agroecologia 10,3.
Mohammadhosseini, M., Frezza, C., Venditti, A., Mahdavi, B., 2021. An overview of the genus Aloysia Palau (Verbenaceae): Essential oil composition, ethnobotany and biological activities. Nat. Prod. Res., doi: org/10.108 0/14786419.2021.1907576. 
Mohammadhosseini, M., Venditti, A., Frezza, C., Serafini, M., Bianco, A., Mahdavi, B., 2021. The genus Haplophyllum Juss.: Phytochemistry and bioactivities—A review. Molecules 26, 4664.
Mohammadhosseini, M., Venditti, A., Sarker, S.D., Nahar, L., Akbarzadeh, A., 2019. The genus Ferula: Ethnobotany, phytochemistry and bioactivities - a review. Ind. Crop Prod. 129, 350-394.
Moody, J.O., Robert, V.A., Connolly, J.D., Houghton, P.J., 2005. Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae). J. Ethnopharmacol. 104, 87-91.
Nahar, L., El-Seedi, H.R., Khalifa, S.A.M., Mohammadhosseini, M., Sarker, S.D., 2021. Ruta Essential Oils: Composition and Bioactivities. Molecules 26, 4766.
Nalawade, A.S., Gurav, R.V., Patil, A.R., Patwekar, M., Patwekar, F. 2022. A comprehensive review on morphological, genetic and phytochemical diversity, breeding and bioprospecting studies of genus Chlorophytum Ker Gawl. from India. Trends Phytochem. Res. 6(1), 19-45.
Nia, R., Paper, D.H., Essien, E.E., Iyadi, K.C., Bassey, A.I.L., Antai, A.B., Franz, G., 2004. Evaluation of the antioxidant and anti-angiogenic effects of Sphenocentrum jollyanum Pierre. Afr. J. Biomed. Res. 7, 129-132.
Odinokov, V.N., Galyautdinov, I.V., Nedopekin, D.V., Khalilov, L.M., Shashkov, A.S., Kachala, V.V., Dinan, L., Lafont, R., 2002. Phytoecdysteroids from the juice of Serratula coronata L. (Asteraceae). Insect Biochem. Mol. Biol. 32, 161-165.
Odugbemi, T.T., 2006. Outline and Pictures of Medicinal Plants from Nigeria. 1st Ed, Nigeria: University of Lagos Press.
Oke, J.M., Hamburger, M.O., 2002. Screening of some Nigeria medicinal plant antioxidant activity using 2, 2-Diphenyl-picryl-hydrazyl radical. Afr. J. Biomed. Res. 5, 77-79.
Olaoluwa, O., Taiwo, O., Nahar, L., Sarker, S.D., 2022. Ethnopharmacology, phytochemistry and biological activities of selected African species of the genus Ficus. Trends Phytochem. Res. 6(1), 46-69.
Olorunnisola, O.S., Fadahunsi, O.S., Adegbola, P., 2017. A Review on ethno-medicinal and pharmacological activities of Sphenocentrum jollyanum Pierre. Medicines 4, 50-61.
Olorunnisola, O.S., Afolayan, A.J., 2011. In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanumPierre. Afr. J. Pharm. Pharmacol. 5(14), 1669-1673.
Olorunnisola, O.S., Akintola, A.A., Afolayan, A.J., 2011. Hepatoprotective and antioxidant effect of Sphenocentrum jollyanum (Menispermaceae) stem bark extract against CCl4-induced oxidative stress in rats. Afr. J. Pharm. Pharmacol. 5, 1241-1246.
Pardhe, H.A., Nagalakshmi, N.C., Hariprasad, M.G., Chourasia, P.K., Nandini, S., 2020. A review: Medicinal plants with antidepressant properties. Indian J. Neurosci. 6(1), 1-5.
Pei, S. 2001. Ethnobotanical approaches of traditional medicine studies. Some experiences from Asia. Pharm. Biol. 39(1), 74-79.
Quadri, A.L., Njinga, N.S., Kola-Mustapha, A.T., Amusa, T.O., Atolani, O., Oladiji, A.T., Bakare-Odunola, M.T., Kambizi, L., 2021. Elemental composition and proximate analysis of five commonly used African medicinal plants. Plant Arch. 21(1), 1360-1366.
Rasoanaivo, P., Ratsimamanga-Urverg, S., Rakoto-Ratsimamanga, A., Raharisololalao, A., 1991. Chemical constituents of three Burasaia spp. (Menispermaceae) from Madagascar. Biochem. Sys. Ecol. 19, 433-437.
Rudel, D., Bathori, M., Gharbi, J., Girault, J.P., Racz, I., Melis, K., Szendrei, K., Lafont, R., 1991. New ecdysteroids from Serratula tinctorial. Planta Med. 58, 358-364.
Sadikov, Z., Saatov, Z., Garcia, M., Girault, J.P., Lafont, R., 2001. Ecdysteroids from Silene claviformis. Chem. Nat. Compd. 37, 262-265.
Sami, A., Usama, M., Saeed, M.M., Akram, M., 2021. Medicinal plants with non-steroidal anti-inflammatory-like activity. Mediterr. J. Pharm. Pharm. Sci. 1(3), 1-8.
Singh, R., 2016. Chemotaxonomy: A tool for plant classification. J. Med. Plants Stud. 4(2), 90-93. 
Sivarajan, V.V., 1991. Introduction to the Principles of Plant Taxonomy, Cambridge University Press, 1991.
Sivasubramanian, A., Gadepalli, K.K., Rathnasamy, R., Campos, A.M., 2013. A new antifeedant clerodane diterpenoid from Tinospora cordifolia. Nat Prod Res. 27(16), 1431-1436. 
Sousa, R.M.F., Lira, C.S., Rodrigues, A.O., Morais, S.A.L., Queiroz, C.R., Chang, R., 2014. Atividadeantioxidante de extratos de folhas de ora-pro-nóbis (Pereskia aculeata Mill.) usandométodosespecométricosevoltamétricos. J. Biosci. 30, 448-457.
Tabekoueng, G.B., Mvot-Akak, C., Langat, M.K., Azebaze, A.G.B., Waffo, A.F.K., Mulholland, D.A., Vardamides, J.C., 2019. The chemical constituents of Penianthus longifolius Miers. Phytochem. Lett. 30, 103-106.
Tane, P., Wabo, H.K., Ayafor, J.F., Sterner, O., 1997. Peniankerine, an 18-norclerodane diterpenoid from the stem bark of Penianthus zenkeri. Phytochemistry 46, 165-167.
Tiwari, M., Kakkar, P., 2009. Plant derived antioxidants - Geraniol and camphene protect rat alveolar macrophages against E-BHP induced oxidative stress. Toxicol. In Vitro 23, 295-301.
Udoh, I.P., Aladenika, S.T., Uzoamaka, C.M., Onyebueke, E., Adaze, A.N.C., Anulika, O.O., 2021. Comparison of antifungal activities of methanol leaves extract of Sphenocentrum jollyanum (SJ) Pierre (Moon Seed) and conventional antifungal drugs using Fusarium Isolates. Pharmacol. Online 1, 62-73.
Uka, E., Ewere, E.G., Effiong, G.S., 2021. Anti-inflammatory potential of ethanol leaf extract of Sphenocentrum jollyanum in experimental mice. GSC Adv. Res. Rev. 07(01), 146-156.
Uka, E., Etim, O.E., Effiong, A.O., Jacobs, I.E., 2020. Phytochemicals, acute toxicity and in-vitro antioxidant activity of ethanol extract of Sphenocentrum jollyanum leaves. J. Drugs Pharm. Sci. 4(2), 10-20.
Venditti, A., 2018. What is and what should never be: Artifacts, improbable phytochemicals, contaminants and natural products. Nat. Prod. Res., doi: org/10.1080/14786419.2018.1543674.
Walsh, C.T., Yang, T., 2017. Natural Product Biosynthesis: Chemical Logic and Enzymatic machinery. London: Royal Society of Chemistry.
Woode, E., Amidu, N., Owiredu, K., Boakye, G., Ansah, C., Duweijua, M., 2009. Antidepressant-Like effects of an ethanol extract of Sphenocentrum jollyanum Pierre roots in mice. Int. J. Pharmacol. 5, 22-29.
Wopara, I., Uwakwe, A.A., Wegwu, M.O., Modo, E.U., Anyalenkeya, S.C., 2019. Effect of ethanolic root extract of Sphenocentrum jollyanum, Baphia nitida, Pinus koraiensis, and Sildenafil on some haematological test parameters in Albino Wistar rats. Int. J. Sci. Res. Innov. 6(3), 44-48.
Yingyongnarongkul, B., Suksamrarn, A., 2020. 25-Deoxyecdysteroids: synthesis and moulting hormone activity of two C-25 epimers of inokosterone, Sci. Asia 26 15-20.
Zhan, Z.J., Zhanga, X.Y., Houa, X.R., Lib, C.P., Shan, W.G., 2009. New diterpenoids from Tinospora capillipes. Helv. Chim. Acta 92, 790-794.
Zhang, G., Ma, H., Hu, S., Xu, H., Yang, B., Yang, Q., Xue, Y., Cheng, L., Jiang, J., Zhang, J., Wang, F., Zhang, Y., 2016. Clerodane-type diterpenoids from tuberous roots of Tinospora sagittata (Oliv.) Gagnep. Fitoterapia 110, 59-65.