فهرست مقالات Nephroprotective

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  1 - Combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana prevents renal damage and dyslipidemia in benign prostatic hyperplasia induced rats
  رابرت اورکو پوول آنیام امانوئل اویو اوبینا آجا
  10.30495/medherb.2021.688096
  Background & Aim: A combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves are used for the treatment of benign prostatic hyperplasia, but there is no scientific data on its safety level and effects on vital organs and biochemical parameter چکیده کامل

  Background & Aim: A combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves are used for the treatment of benign prostatic hyperplasia, but there is no scientific data on its safety level and effects on vital organs and biochemical parameters. This study investigated the effects of a combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves (CESHL) on the lipid profile and kidney function of benign prostatic hyperplasia (BPH) induced rats.Experimental: A total of 21 rats were used for the acute toxicity study, while 30 were randomly distributed into five groups comprising six rats each (n = 6) for the BPH study. Group 1 served as normal control, while group 2 was BPH control that received 5 mg/kg of testosterone propionate/day for 28 consecutive days without treatment. Groups 3 – 5 received 5 mg/kg of testosterone propionate/day for 28 days but after an hour, they treated with 5 mg/kg of finasteride, 200 and 600mg/kg of CESHL/day, respectively, for 28 days.Results: The acute toxicity result of CESHL indicated no mortality or any sign of toxicity. Administration of the extract caused a significant reduction (p<0.05) of theprostate weight, triacylglycerol, cholesterol, low-density lipoprotein (LDL-C), urea and creatinine concentrations in the treated groups when compared to the BPH control. A significant increase (P<0.05) in High-Density Lipoprotein (HDL) concentration was observed in all treated groups when compared to the BPH control group. Histological outcomes of rats’ kidneys corroborated these findings.Recommended applications/industries: These results indicate that the combined extracts possess antilipidemic and nephroprotective effects, which might help in the management of complications that might arise during BPH. پرونده مقاله
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  2 - Nephroprotective activity of Mammea africana stem bark against paracetamol induced kidney injury
  چودفیوم اوکوکون بائو میشل
  Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatmen چکیده کامل

  Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental: The nephroprotective effect of the extract was evaluated by the determination of some kidney function parameters such as serum urea and creatinine, electrolyes (K+, Na+, Cl- and HCO-3), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA) and histopathological study of the liver. Results & Discussion: The administration of the stembark extract caused significant dose-dependent reduction of high levels of serum creatinine and urea. The electrolytes levels were not affected. Histology of the kidney sections of extract and silymarin- treated animals showed reductions in the pathological features compared to the paracetamol- treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked nephroprotective effect of the stembark extract of M. africana Recommended applications/industries: The results show that the stembark extract of Mammea africana has nephroprotective potential which may be due to its antioxidant effect activity. پرونده مقاله
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  3 - Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in rats
  چیکا اونبو اوبینا آجا چینوندو نوروم جوزفات اونووسونیه کیوما دورو اوبینا جوئل
  10.30495/medherb.2022.693310
  Background & Aim: Management/ treatment of illness and maintenance of well-being using herbal medicines is the oldest and most popular form of healthcare practice known to humankind that has been practiced by all cultures in all ages throughout the history of evolut چکیده کامل

  Background & Aim: Management/ treatment of illness and maintenance of well-being using herbal medicines is the oldest and most popular form of healthcare practice known to humankind that has been practiced by all cultures in all ages throughout the history of evolution. The ethanol extract of Jatropha tanjorensis leave was evaluated for it pharmacological potency in alloxan-induced diabetes in albino rats.Experimental: Twenty-four adult male albino rats weighing 120-180g were randomly divided into six groups of four rats per group. Group I (Normal control) were given 0.2 mL of water. Group II (Negative control): were untreated diabetic rats. Group III were Diabetic rats treated with reference drug (glibenclamide at 5 mg/kg b.wt) which served as positive control. Group IV – VI were Diabetic rats treated with Jatropha tanjorensis leaf extract at a dose of 200 mg/kg b.wt, 400 mg/kg b.wt, and 600 mg/kg b.wt, respectively. Administrations were done orally for 14 days. Blood was collected from the tail of the rats to determine the blood glucose level on the 4th, 9th and 14th day of the study.Results: The extract significantly reduced the blood glucose level. The Jatropha tanjorensis leaf extract showed dose dependent significant (P<0.05) decrease in the triacylglycerol (TAG), low density lipoprotein (LDL), Cholesterol, total white blood cell (TWBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, urea, creatinine level as well as significant (P<0.05) increase in hemoglobin (Hb), packed cell volume (PCV), red blood cell (RBC) and albumin level when compared with diabetic untreated group (negative control). Diabetic-related alteration in rat serum biochemical indices were significantly improved by the extract.Recommended applications/industries: The outcome of the research gave credence to the folk use Jatropha tanjorensis leaf in the treatment of diabetes and its health related dysfunctions. پرونده مقاله