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دسترسی آزاد مقاله
1 - In vitro bioactivity of silicophosphate glasses doped with ZnO, SrO or CuO
H. A. ElBatal A. A. El-Kheshen M. A. Marzouk N. A. Ghoneim F. H. ElBatal M. A. Ouis A. M. Fayad A. M. AbdelghanyAbstractSilicophosphate glasses with variable divalent ion dopants (Zn2+, Sr2+ or Cu2+) were prepared via melt annealing route. Parent and doped glasses were thermally heat-treated through a two-step regime to be converted into their glass–ceramic derivatives. Fourier t چکیده کاملAbstractSilicophosphate glasses with variable divalent ion dopants (Zn2+, Sr2+ or Cu2+) were prepared via melt annealing route. Parent and doped glasses were thermally heat-treated through a two-step regime to be converted into their glass–ceramic derivatives. Fourier transform infrared (FT-IR) spectral data were recorded for parent glasses and their glass–ceramics derivatives to identify the structural building units which reveal vibrational bands due to both main phosphate and some silicate groups and to verify the bioactivity behavior after immersion in diluted phosphate solution. X-ray diffraction studies indicate the formation of different phosphate and silicate crystalline phases in the derived glass–ceramics which varied with the type of dopant oxide. SEM investigations of the glass–ceramics before and after immersion in phosphate solution showed multicomponent microcrystalline textures in the studied micrographs before immersion. Nodular-shaped microcrystalline features were identified after immersion in phosphate solution referring to the formation of crystalline hydroxyapatite. The undoped glass–ceramic is identified to crystallize in almost equal silicate and phosphate phases, while with the dopant ZnO, SrO or CuO, the crystalline phases are only of phosphates, while the silicate phase is assumed to be retained in the surrounding remaining vitreous boundaries. پرونده مقاله -
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2 - Bioactive Glass in Medicine: A Mini-Review of Composition, Properties, Bioactivity Mechanisms, and Clinical Applications
S Mahboubizadeh P Noroozi O AshkaniFrom ancient civilizations using gold and silver for healing to the metal surgical instruments of the Renaissance, the introduction of anesthetic and antiseptic treatments in the 19th century, and the 20th century medical device revolution, the history of medical materi چکیده کاملFrom ancient civilizations using gold and silver for healing to the metal surgical instruments of the Renaissance, the introduction of anesthetic and antiseptic treatments in the 19th century, and the 20th century medical device revolution, the history of medical materials is an inventive one. Today, modern healthcare is being shaped by materials like bioglass.Dr. Larry Hench invented bioglass in 1969, and it has since been used extensively in biological and medical application. This brief study covers composition, bioactivity mechanisms, and healthcare applications of bioglass. Bioglass has a wide range of applications, including bone regeneration, tissue engineering, implantable devices, and more thanks to its remarkable bioactivity, biocompatibility, and tissue bonding properties. The sol-gel synthesis method, offering lower processing temperatures and uniform compositions, has gained prominence. Although there are still issues with optimizing bioglass for various biomedical uses, current research and innovation show promise for the material's future advancement in healthcare. پرونده مقاله -
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3 - <i>Sphenocentrum jollyanum</i> Pierre (Menispermaceae): From traditional medicine to pharmacological activity and chemical constituents
Idayat Akinwumi Mubo SonibareIn Yoruba, southwestern Nigeria, Sphenocentrum jollyanum Pierre is known as “Akerejupon”. S. jollyanum is commonly used in traditional medicine to treat a variety of ailments because of its diverse biological activities. However, a thorough examination of th چکیده کاملIn Yoruba, southwestern Nigeria, Sphenocentrum jollyanum Pierre is known as “Akerejupon”. S. jollyanum is commonly used in traditional medicine to treat a variety of ailments because of its diverse biological activities. However, a thorough examination of the traditional, pharmacological, and phytochemical properties of S. jollyanum is yet lacking. Different plant organs are used as aphrodisiacs, treatments for chronic illnesses including coughs and ulcers, and for malaria by traditional medicinal practitioners. The pharmacological activities of this plant include anti-diabetic, antioxidant, hepatoprotective, anti-inflammatory, antimalarial, anti-allergy, antimicrobial, among others. Some of the isolated compounds from this plant are columbin, isocolumbin, fibleucin, atrotosterone A, pinnatasterone, polypodine B, and 20-hydroxyecdysone. In order to explore this plant for further research and to know its potential effect towards pharmaceutics, the present review aims to provide an updated summary of documents sourced from recent publications regarding ethnomedicinal uses, pharmacology, and phytochemistry of S. jollyanum. پرونده مقاله -
دسترسی آزاد مقاله
4 - ‘Helencha’ (<i>Enhydra fluctuans</i> Lour.): A brief overview
Lutfun Nahar Satyajit D. Sarker‘Helencha’ (Enhydra fluctuans Lour.), a well-known but underused leafy vegetable with medicinal properties, belongs to the family Asteraceae (alt. Compositae). This aquatic or semi-aquatic herb is also known by several other common names such as ‘buffa چکیده کامل‘Helencha’ (Enhydra fluctuans Lour.), a well-known but underused leafy vegetable with medicinal properties, belongs to the family Asteraceae (alt. Compositae). This aquatic or semi-aquatic herb is also known by several other common names such as ‘buffalo spinach’, ‘English marsh herb’, ‘godobos’, ‘harkuch’, ‘hilmochikah’, ‘hinche’, ‘jalabrahmi’, ‘phak bung ruem’ and ‘zhao ju’.Enhydra fluctuans is synonymous with Coreopsis anagallis, Enhydra anagallis, E. linifolia, E. longifolia, E. paludosa, E. wollsii, Tetraotis longifolia, T. paludosa and Meyera fluctuans. This plant is indigenous to Bangladesh and India, but also native to other South- East Asian countries like Burma, Indonesia, Malaysia, Sri Lanka, Thailand and Vietnam, and introduced in various other countries, e.g., China, the Philippines, Senegal and Zaire. پرونده مقاله -
دسترسی آزاد مقاله
5 - Bioactive essential oils from the Cameroonian rain forest: A review - Part II
Jean Duplex Wansi Norbert Sewald Lutfun Nahar Claire Martin Satyajit Dey SarkerEighty-nine essential oil analyses carried out on Cameroonian plant material by gas chromatography are reviewed, and structures of sixty one main oil compounds are presented. Plant samples had been collected all over the rainforest area and further northwards, covering چکیده کاملEighty-nine essential oil analyses carried out on Cameroonian plant material by gas chromatography are reviewed, and structures of sixty one main oil compounds are presented. Plant samples had been collected all over the rainforest area and further northwards, covering forty plant species belonging to ten families. For these plants, common names, traditional use as well as bioactivity and toxicity of their essential oils in vitro and in vivo are compiled. Data show that oils from leaves, bark, roots, fruit, rhizome or seeds display their own one to four main essential oil components. Each of them contributing more than 10% to over 90% of the oil´s volume, which sums up to species-unique essential oil fingerprints and decreasing similarity of these fingerprints with increasing phylogenetic distance between species. This review article shows that the environmental factor include, temperature, rainfall (Littoral region), humidity (Center, South, East and West regions) and solar radiation (Adamaoua, North and Far-north regions) as well as the soil nutrients influence the secondary metabolite composition of the plants. Bioassays valorized traditional use of a good number of oils, for example against the dermatophytic fungus Trichophyton rubrum being twice as effective as amphothericin B®; against the chloroquine resistant Plasmodium falciparum; against cancer cell lines; and against a variety of human pathogen bacteria, being up to ten times as effective as ciproxin®, lidaprim®, tetracycline hydrochloride® and lidaprim®. Importantly, in an experiment employing the stored product beetle Callosobruchus maculatus, the leaf oil of Lippia adoensis (Verbenaceae) indicated neurotoxicity, so that preparations should be applied with care. Follow up work may focus on bioassays with commercial pure compounds, with the goal to improve effectivity and doses calculation for traditional essential oil medicines and agricultural products. پرونده مقاله -
دسترسی آزاد مقاله
6 - Bioactive essential oils from the Cameroonian rain forest: A review - Part I
Jean Duplex Wansi Norbert Sewald Lutfun Nahar Claire Martin Satyajit Dey SarkerForty traditional medicinal plants from the Cameroonian rain forest belonging to twelve families are reviewed related to botanical description, taxonomy, common names, traditional use, essential oil composition as well as bioactivity and toxicity of their essential oils چکیده کاملForty traditional medicinal plants from the Cameroonian rain forest belonging to twelve families are reviewed related to botanical description, taxonomy, common names, traditional use, essential oil composition as well as bioactivity and toxicity of their essential oils. A correlation is drawn between traditional use and bioactivity in vitro/in vivo, and structures of seventy-three main oil ingredients are given. Collected data indicate that plant essential oils unfold their biological activity related to functional groups of major and minor compounds, in a complex, fine-tuned interaction, modulated by environmental factors like the vegetation cycle of the plant, the altitude and the presence or absence of plant pathogen microbes, certain crop weevils as well as nematodes, varying with climatic seasons. Comparison of traditional use with laboratory results indicates effectivity of a good number of essential oils received from various plant parts, like leaves, bark, fruit, roots and rhizomes against Plasmodium falciparum, food borne microbes, dermatophytes, the malaria vector Anopheles gambiae, cancer cell lines, river blindness as well as plant pathogen weevils and fungi. However, toxicological studies are needed before any recommendation for application can be given. Importantly, leaf and fruit oil of Cupressus lusitanica (Cupressaceae) displayed strong acute toxicity in animal model, and the bark oil of Cinnamomum verum (Lauraceae) showed high toxicity in a normal cell line, so that preparations should be applied with care. Preformulation and formulation studies will be needed to develop a range of suitable dosage forms to introduce optimized pharmaceuticals (high active, low toxic) as replacement of current crude plant essential oil preparations in Cameroon and other Subsaharan countries. پرونده مقاله -
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7 - Novel BCP-Bioactive Glass-Akermanite/PCL Composite Scaffold: Physical and Mechanical Behavior, and in Vitro Bioactivity
Ebrahim karamian shakiba saghirzadeh darkiIn the present study, biphasic calcium phosphate (BCP)-bioactive glass-akermanite/PCL composite scaffold with high porosity (80%) was successfully fabricated using polymeric sponge replication and dip–coating methods. The composite was characterized via X-ray diff چکیده کاملIn the present study, biphasic calcium phosphate (BCP)-bioactive glass-akermanite/PCL composite scaffold with high porosity (80%) was successfully fabricated using polymeric sponge replication and dip–coating methods. The composite was characterized via X-ray diffraction (XRD) and scanning electron microscopy (SEM). In addition, physical and mechanical properties of the composite were evaluated using porosity and compressive strength measurements. In vitro bioactivity of the composite was carried out using simulated body fluid solution (SBF). Results showed that PCL, as a polymeric coating, incremented the mechanical strength of ceramic scaffolds from 0.97 to 1.9MPa, confirming its fundamental role in recovering the mechanical properties of scaffolds in bone tissue engineering. Bioactivity evaluation resulted in developing an apatite–like layer on the surface of the scaffolds, which verified the proper bioactivity of the scaffolds. The results showed that this novel composite scaffold has the potential to be applied as a temporary substrate for bone tissue engineering. پرونده مقاله -
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8 - Evolution of Biological Properties of Bioactive Diopside and Wollastonite for Bone Tissue Engineering
Ruhollah Zamani Foroushani Ebrahim karamian Mohammad RafieniaThe present study aimed to synthesize and characterize diopside (CaMgSi2O6) and wollastonite (CaSiO3) nano-bioceramics via a combination of mechano-chemical and calcination processes. In vitro biomineralization and cell responses of wollastonite and diopside were carrie چکیده کاملThe present study aimed to synthesize and characterize diopside (CaMgSi2O6) and wollastonite (CaSiO3) nano-bioceramics via a combination of mechano-chemical and calcination processes. In vitro biomineralization and cell responses of wollastonite and diopside were carried out using simulated body fluid (SBF) for up to 28 days and MG-63 osteoblast cells. Results revealed excellent tissue biomineralization of wollastonite and diopside through generating an apatite-like layer on the surface of nano-bioceramics. Wollastonite and diopside cell responses eventuated non-cytotoxicity by MG-63 osteoblast cells, and their viability and cell proliferation were verified. Results of alizarin red staining and alkaline phosphate enzyme of diopside and wollastonite evidenced great bioactivity and tissue biomineralization with respect to the release of Ca2+ and high absorption related to calcium activity, and high activity and growth of alkaline phosphate enzyme to repair bone tissue of diopside, and wollastonite was enhanced in contact with the MG-63 osteoblast cells. Regarding the addition of Mg2+ into the calcium-silicate network for the chemical stability network to improve biological properties, results of biological assays verified that diopside possessed high biological and cell responses in comparison to wollastonite; and both of them can be suggested as great bioactive and biocompatible candidates for biomedical applications. پرونده مقاله -
دسترسی آزاد مقاله
9 - Survey and Evaluation of Diopside Nanostructure (DSN) Bioactivity in Biomedical Application
hassan gheisariDiopside (DS) is a monoclinic pyroxene mineral with composition MgCaSi2O6. Lately,diopside (DS) has been introduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength and toughness than those of hydroxyapatite (HT). In this project چکیده کاملDiopside (DS) is a monoclinic pyroxene mineral with composition MgCaSi2O6. Lately,diopside (DS) has been introduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength and toughness than those of hydroxyapatite (HT). In this project, bioactivity of diopside (DS) powder were evaluated and investigated. For synthesized of diopside (DS) powder, magnesium (Mg), calcite (CaCO3) and nano silicium (SiO2) powders was mechanically activate for different times. After that, the prepared powders were blended with ammonium chloride (NH4Cl) and put on various temperatures. In this part, for survey of bioactivity evaluation, the obtained dioside (DS) powders were pressed and immersed in Kukobo solution (SBF)The results indicated that nano-struacture diopside powder with crystalline size is 40 nm. The apatite formation ability,bioactivity and good mechanical behavior make it a good candidate in bone implant materials and open new insights in biomedical applications. In sum up, our findings indicated that nanostructure diopside (DS) bio-ceramic is bioactive and might make an good candidate for biomedical purposes. پرونده مقاله -
دسترسی آزاد مقاله
10 - Survey and Evaluation of Hardystonite Nanostructure (HTN) Bioactivity in Biomedical Engineering
hassan GHEISARIHardystonite (HT) is a monoclinic pyroxene mineral with composition Ca2ZnSi2O7. Lately, Hardystonite (HT) has been introduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength and toughness than those of hydroxyapatite (HA). In th چکیده کاملHardystonite (HT) is a monoclinic pyroxene mineral with composition Ca2ZnSi2O7. Lately, Hardystonite (HT) has been introduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength and toughness than those of hydroxyapatite (HA). In this project, bioactivity of hardystonite (HT) powder were evaluated and investigated. For synthesized of hardystonite (HT) powder, Zinc (Zn), calcite (CaCO3) and nano silicium (SiO2) powders was mechanically activate for different times. After that, the prepared powders were blended with ammonium chloride (NH4Cl) and put on various temperatures. In this part, for survey of bioactivity evaluation, the obtained hardystonite (HT) powders were pressed and immersed in Kukobo solution (SBF)The results indicated that nano-struacture hadystonite powder with crystalline size is 40 nm. The apatite formation ability,bioactivity and good mechanical behavior make it a good candidate in bone implant materials and open new insights in biomedical engineering. The apatite formation ability,bioactivity and good mechanical behavior make it a good candidate in bone implant materials and open new insights in biomedical engineering. پرونده مقاله -
دسترسی آزاد مقاله
11 - Survey and Evaluation of Diopside Nanostructure (DSN) Bioactivity in Biomedical Application
Hassan Gheisari Ebrahim Karamian Ali SoheilyDiopside (DS) is a monoclinic pyroxene mineral with composition MgCaSi2O6. Lately,diopside (DS) has beenintroduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength andtoughness than those of hydroxyapatite (HT). In this project, چکیده کاملDiopside (DS) is a monoclinic pyroxene mineral with composition MgCaSi2O6. Lately,diopside (DS) has beenintroduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength andtoughness than those of hydroxyapatite (HT). In this project, bioactivity of diopside (DS) powder wereevaluated and investigated. For synthesized of diopside (DS) powder, magnesium (Mg), calcite (CaCO3)and nano silicium (SiO2) powders was mechanically activate for different times. After that, the preparedpowders were blended with ammonium chloride (NH4Cl) and put on various temperatures. In this part, forsurvey of bioactivity evaluation, the obtained dioside (DS) powders were pressed and immersed in Kukobosolution (SBF)The results indicated that nano-struacture diopside powder with crystalline size is 40 nm.The apatite formation ability, bioactivity and better mechanical behavior make it a good candidate in boneimplant materials and open new insights in biomedicalapplications. پرونده مقاله -
دسترسی آزاد مقاله
12 - بررسی زیست فعالی نانو کامپوزیت آپاتیت طبیعی- دیوپساید متراکم سازی شده به روش زینترینگ دو مرحله ای جهت مصارف پزشکی
نسرین رفیعی ابراهیم کرمیاندر این تحقیق به منظور دستیابی به کامپوزیت مناسب آپاتیت طبیعی- دیوپساید با خواص زیست فعالی مطلوب، ابتدا ترکیبات مختلف هیدروکسی آپاتیت طبیعی و دیوپساید (حاوی 10، 20، 30 و 40 درصد وزنی دیوپساید)، تهیه و تحت عملیات حرارتی زینترینگ دو مرحلهای متراکم سازی شدند و سپس استحکام چکیده کاملدر این تحقیق به منظور دستیابی به کامپوزیت مناسب آپاتیت طبیعی- دیوپساید با خواص زیست فعالی مطلوب، ابتدا ترکیبات مختلف هیدروکسی آپاتیت طبیعی و دیوپساید (حاوی 10، 20، 30 و 40 درصد وزنی دیوپساید)، تهیه و تحت عملیات حرارتی زینترینگ دو مرحلهای متراکم سازی شدند و سپس استحکام فشاری سرد (CCS) و آپاتیت سازی نمونهها مورد ارزیابی قرار گرفت. همچنین جهت مشخصهیابی نمونهها از میکروسکوپ الکترونی روبشی (SEM)، طیف سنجی پراش انرژی پرتو ایکس (EDS)، و آزمون پراش پرتو ایکس (XRD) استفاده شد. نتایج نشان داد که بیشترین میزان استحکام (MPa 63) متعلق به نمونه کامپوزیت حاوی 20% دیوپساید بود و تصاویر SEM و طیف میکروآنالیز EDS ، تشکیل رسوب آپاتیتی بر سطح این نمونه پس از 28 روز غوطهوری در محلول شبیه سازی شده بدن را تایید کردند. همچنین یون سنجی انجام شده بر روی این نمونه، کاهش غلظت یون کلسیم از 100 به 93 و یون فسفر از 31 به 28(ppm) را نشان داد که بیانگر تشکیل آپاتیت بر روی این نمونه میباشد. لذا با توجه به نتایج به دست آمده، نمونه کامپوزیتی حاوی 20 درصد وزنی دیوپساید و 80 درصد وزنی هیدروکسی آپاتیت طبیعی را میتوان به عنوان یک نانوبیوسرامیک مطلوب جهت مصارف پزشکی از جمله ارتوپدی معرفی کرد. پرونده مقاله -
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13 - ساخت و مشخصه یابی داربست تیتانیومی متخلخل پوشش داده شده با آکرمانیت
مسعود ارسطویی علی دوست محمدیهدف از این پژوهش، ساخت و مشخصه یابی داربست تیتانیومی پوشش داده شده با آکرمانیت برای استفاده در مهنـــــدسی بافت استخوان می باشد؛ به منظور ساخت داربست تیتانیومی، پودر تیتانیوم اولیه را با ذرات عوامل فضــاساز (کلرید سدیم) تهیه و همچنیـن پوشش آکرمانیت به روش سل- ژل تهیه و چکیده کاملهدف از این پژوهش، ساخت و مشخصه یابی داربست تیتانیومی پوشش داده شده با آکرمانیت برای استفاده در مهنـــــدسی بافت استخوان می باشد؛ به منظور ساخت داربست تیتانیومی، پودر تیتانیوم اولیه را با ذرات عوامل فضــاساز (کلرید سدیم) تهیه و همچنیـن پوشش آکرمانیت به روش سل- ژل تهیه و بر روی داربست اعمال شد؛ سپس پوشش سنتز شـده به روش سل- ژل بر روی سطح داربست تیتانیومی قرار گرفت؛ داربســت های پوشش داده شده بعد از عملیات حرارتی توسط میکروسکوپ الکترونی روبشـی (SEM) و طیف سنجی توزیــــع انرژی پرتو ایکس (EDX) بررسی شدند؛ برای ارزیابی زیست فعالی از مایع شبیه سازی شده بدن (SBF) استفاده شـــد و تصاویر میکروســــکوپ الکترونی روبشی از سطح داربست تیتانیومی بدون پوشش و داربست تیتانیومی پوشـش داده شده با آکرمــــانیت را پس از 21 و14-7-3 روز غوطه وری در محلول شبیــه سازی شده بدن (SBF) تهیه شد؛ آنالیز پراش پرتو ایکس (XRD) وجود پیک های فاز آکرمانیت را در پوشش تایید کرد؛ طبق نتایج به دســــت آمده، ایجاد یک پوشش آکرمانیت می تواند زیست فعالی سطح داربســت تیتانیومی را افزایش دهد و نتیجه گیری نهایی این پژوهش نشان می دهد داربست تیتانیومی پوشش داده شده با آکرمانیت گزینه مناسبی برای استفاده در مهندسی بافت استخوان خواهد بود. پرونده مقاله -
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14 - Exploring the biological potential of Cruciata taurica (Pall. ex Willd.) Ehrend.: Evaluating antibacterial, antioxidant, antidiabetic, and cytotoxic properties
Shiva Khalil-Moghaddam Roya Moghimi Thomas Efferth Sajedeh MousavianThis study focused on the biological properties of Cruciata taurica, a plant found in the Irano-Turanian region, which has not been extensively studied in terms of its phytochemical and biological activities. The methanolic extract of the plant was obtained and its cyto چکیده کاملThis study focused on the biological properties of Cruciata taurica, a plant found in the Irano-Turanian region, which has not been extensively studied in terms of its phytochemical and biological activities. The methanolic extract of the plant was obtained and its cytotoxic, antibacterial, antidiabetic, and antioxidant properties were investigated. The antibacterial activity of the fractions was evaluated using broth microdilution method, while the antioxidant properties were assessed through the DPPH assay and the cytotoxic properties were determined using the RRA assay. This study revealed that the residual aqueous fraction exhibited the highest extraction yield and the most potent antioxidant activity. The EtOAc fraction showed strong antibacterial activity against certain bacteria, while the n-hexane fraction exhibited greater antidiabetic effects. Additionally, the EtOAc fraction was found to be the most cytotoxic. Overall, the study suggested that C. taurica has potential therapeutic applications due to its various biological properties. پرونده مقاله
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