اثر محافظتی فعالیت های بدنی منظم و گیاهان دارویی بر بافت هیپوکامپ به واسطه مهار آپوپتوز
محورهای موضوعی : دسترسی آزاد
ثریا پور اصغری سیاه اسطلخی
1
*
,
سیدمترضی طیبی
2
,
Lida Moradi
3
,
رسول اسلامی
4
1 -
2 - دانشگاه علامه طباطبائی- تهران- ایران
3 - استادیار دانشگاه آزاد اسلامی تهران شمال
4 - علامه طباطبائئ
کلید واژه: فعالیت های بدنی, گیاهان دارویی, بافت هیپوکامپ, مهار آپوپتوز,
چکیده مقاله :
هدف: آپوپتوز فرایندی بسیار سازمان یافته و برنامه ریزی شده است که نقش حیاتی در نظارت بر انواع رویدادهای سلولی غیر پاتولوژیک دارد، با وجود این تأثیر فعالیت های ورزشی با شدت های مختلف بر آپوپتوز هنوز به طور کامل شناخته شده نیست. گیاهان دارویی از زمان قدیم به عنوان منبع اصلی ترکیبات ضد آپوپتوزی مورد مطالعه قرار می‌گرفت. بنابراین هدف مطالعه حاضر بررسی اثر محافظتی فعالیت های بدنی منظم و گیاهان دارویی بر بافت هیپوکامپ به واسطه مهار آپوپتوز بود. مواد و روش ها: به این منظور در تمامی بانک های اطلاعاتی بخصوصScience of Web ،Pubmed ، Google Octapamine،Aerobic Exercise ، Metabolic disorders های واژه کلید با Mageiran ،SID.IR ،scholar factors risk و غیره، بدون محدودیت سال جستجو انجام گرفت. سپس مقالات بر اساس تمرین و گیاهان دارویی بر نشانگرهای آپوپتوزی بر بافت هیپوکامپ دسته بندی شدند. نتایج: نتایج نشان می دهد استفاده از داروهاي گیاهی و فعالیت های بدنی می تواند بر میزان کاهش آپوپتوز بافت هیپوکامپ اثر داشته باشد. براي درمان بیماري هاي مختلف از جمله بیماري هاي عصبی و خودایمنی گسترش بسیاري یافته است. نتیجه گیری: به طور خلاصه، پژوهش حاضر نشان داد که تمرین می‌تواند فرایند آپوپتوز سلولی را در هیپوکامپ به منظور حفاظت عصبی در مغز تنظیم نماید. همینطور، این مطالعه از شواهدی حمایت می‌کند که تمرین، کاهش بیان ژن های مربوط به آپوپتوز را در مدل حیوانی به‌دنبال داشته باشد. گیاهان دارویی سبب افزایش تکثیر و کاهش میزان آپوپتوز سلول‌های بنیادی عصبی را افزایش داده و میزان آپوپتوز را در آنها کاهش می دهد.
Background: Apoptosis is a highly organized and programmed process that plays a vital role in monitoring a variety of non-pathological cellular events, however, the effect of exercise activities with different intensities on apoptosis is still not fully understood. Medicinal plants have been studied since ancient times as the main source of anti-apoptotic compounds. Therefore, the aim of the present study was to investigate the protective effect of regular physical activities and medicinal plants on the hippocampal tissue by inhibiting apoptosis. Materials and methods: For this purpose, in all databases, especially Science of Web, Pubmed, Google Octapamine, Aerobic Exercise, Metabolic disorders, keywords were searched with Mageiran, SID.IR, scholar risk factors, etc., without year restrictions. Then the articles were categorized based on exercise and medicinal plants on apoptotic markers on hippocampal tissue. Result: The results show that the use of herbal medicines and physical activities can have an effect on the reduction of hippocampal tissue apoptosis. It has been widely used to treat various diseases, including neurological and autoimmune diseases. Conclusion: In summary, the present study showed that exercise can regulate the process of cell apoptosis in the hippocampus for the purpose of neuroprotection in the brain. Also, this study supports the evidence that exercise reduces the expression of apoptosis-related genes in an animal model. Medicinal plants increase the proliferation and decrease the rate of apoptosis of neural stem cells and decrease the rate of apoptosis in them.
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