نانوذرات پروتئینی به‌عنوان حامل‌های دارورسانی در درمان سرطان
محورهای موضوعی : نانوبیوتکنولوژی
1 - 1- دانشجوی دکتری ریززیست فناوری، گروه ریززیست فناوری، دانشکده علوم زیستی، دانشگاه تربیت مدرس، تهران، ایران
کلید واژه: دارورسانی, سرطان, نانوذرات پروتئینی, نانوبیوتکنولوژی.,
چکیده مقاله :
سرطان همچنان یکی از کشنده‌ترین بیماری‌ها در سراسر جهان محسوب می‌شود و علی‌رغم اینکه محققین، بسیاری از رویدادهای پیچیده‌ای که منجر به بروز سرطان و متاستاز می‌شوند را مورد بررسی قرار داده‌اند و در این زمینه پیشرفت خوبی داشته‌اند، با این حال هنوز درمان موثری برای سرطان وجود ندارد. یکی از چالش‌های اساسی در درمان سرطان، آزاد شدن دارو در جریان خون و نرسیدن دوز موثر دارو به بافت سرطانی است که سبب می‌شود بیماران دوز بالاتری از دارو را استفاده و به طور مکرر دارو مصرف کنند که منجر به ایجاد مقاومت‌های دارویی می‌شود لذا برای درمان موثر سرطان، باید از سیستم‌های دارورسانی استفاده شود که بتوانند دوز موثر دارو را به بافت مدنظر برسانند و بر محدودیت فوق فائق آیند. محققین با قصد انتقال هدفمند دوز موثر دارو از علم نانو و نانوساختارهای متنوع کمک گرفته‌اند. در این میان نانوذرات پروتئینی یکی از نانوساختارهایی محسوب می‌شوند که به دلیل فراوانی در منابع طبیعی، زیست سازگاری، زیست تخریب پذیری، فرآیند سنتز آسان، عدم سمیت بالقوه و امکان اصلاح سطح، می‌توانند جایگزین خوبی برای بهبود خواص فارماکوکینتیک و فارماکودینامیک انواع مختلف مولکول‌های دارو و درمان امیدوارکننده‌ای برای انواع مختلف بیماری‌ها و از جمله سرطان باشند.
Cancer is still one of the deadliest diseases worldwide. Although researchers have studied many of the complex processes that lead to cancer and metastasis and have made good progress in this field, there is still no effective treatment for cancer. One of the biggest challenges in cancer treatment is the release of drugs into the bloodstream and the fact that the effective dose of the drug does not reach the cancerous tissue, causing patients to use a higher dose of the drug and take the drug repeatedly, leading to the development of drug resistance. Therefore, for effective treatment of cancer, drug delivery systems that can deliver the effective dose of the drug to the target tissue and overcome the above limitations must be used. Researchers have enlisted the help of nanoscience and various nanostructures to target and deliver an effective dose of the drug. Meanwhile, protein nanoparticles are one of the nanostructures that can be a good alternative for improving the pharmacokinetic and pharmacodynamic properties of various types of drug molecules, as they are abundant in natural sources, biocompatible, and biodegradable, easily synthesized, potentially non-toxic, and surface modifiable. and be a promising treatment for various types of diseases, including cancer.
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