The positive effect of high-intensity interval swimming on improving motor performance in rats with Parkinson's disease model

Subject Areas : Journal of Physical Activity and Hormones

Somayeh Rashidfard ^{1 *} , Mohammad Amin Edalatmanesh ²

1 - PhD in Exercise Physiology, IB Extended Essay Coordinator in Mehr-e-Taban International School, Mehr-e-Taban Academy, Shiraz, Fars, Iran
2 - Associate professor in Physiology, Department of biology, Shiraz branch, Islamic Azad University, Shiraz, Iran

Received: 2024-07-27 Accepted : 2024-12-23 Published : 2024-10-03

Keywords: Parkinson’s disease, Catalepsy test, HIIT, Swimming,

Abstract :

Introduction: The effect of swimming on the behavioral complications of Parkinson’s disease has been investigated recently. However, based on our research, accurate and reliable information is still not available to clarify the effect of this type of exercises. So, the present study designed amid to investigate the effect of high-intensity interval swimming on improving performance in rats with Parkinson's disease model. Methods & Material: In this experimental study, twenty-one 8 to 10-week-old male Wistar rats (weight 200±10.2 grams) were divided into three groups (7 rats in each group), including healthy control, disease control and swimming. Parkinson's disease was induced through intraperitoneal injection of reserpine for 5 consecutive days in the rats of disease control and swimming groups and the rats in the swimming group performed high-intensity interval swimming according to the training protocol for 6 consecutive weeks. Data were analyzed using one-way ANOVA and along with LSD post hoc test through SPSS-22 at the P<0.05. Results: Based on the result of Shapiro Wilk test, the distribution of data in the present study was completely normal. There was a significant difference in the time of bar test between healthy group and diseased control group (P<0.05). There was also a significant decrease in the time of bar test swimming group with both diseased and healthy groups (P<0.05). Conclusion: In general, the findings of the present study showed that swimming training could significantly improve the motor disorder in rats with Parkinson’s disease. The results also showed the beneficial effects of swimming on the improvement of motor activity in rats.

References:

1. Alam M, Schmidt WJ. (2002). Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav Brain Res, 136: 317–324.
2. Karling R, Luciani A, Jibran Y. (2020). An Open-Source Automated Bar Test for Measuring Catalepsy in Rats. Novel Tools and Methods, 7(3): 1–5.
3. Rashidfard S, Moghdasi M, Edalatmanesh MA, Hojjati S. (2024). The effect of high intensity interval swimming on DJ-1 and mir-874 gene expression of hippocampal cells in rats with Parkinson’s disease. Journal of Applied Health Studies in Sport Physiology, 11(1): 251-260.
4. Lesage S, Lunati A, Houot M, Romdhan SB, Clot F, Tesson C, et al. (2020). Characterization of recessive Parkinson disease in a large multicenter study. Annals of Neurology, 88: 843–850.
5. Sacheli MA, Neva JL, Lakhani B, Murray DK, Vafai N, Shahinfard E, et al. (2019). Exercise increases caudate dopamine release and ventral striatal activation in Parkinson’s disease. Movement Disorders, 34: 1891–1900.
6. Tajik B, Nazari M, Fanaei H, Sadeghi M. (2023). Effect of swimming along with whey on improving movement disorders and neuron apoptosis in Parkinson’s disease induced by Rotenon. Mazandaran University Journal, 2(33):27-32.
7. KeshavarzianF, Dollah A, Rafieirad M, (2021). Effect of four weeks exercise and Oleorpinon oxidative stress in barin tissue in Parkinson’s disease model in Rats. Scientific Research Journal of Experimental Animal Biology, 10T 2(38): 67-76.
8. Azizi S, Kargarfard M, Azizi R. (2014). Effect of eight weeks exercise in water on lower body muscle strength in patients with Parkinson’s disease. Journal of Isfahan University, 16(1): 60-66.
9. Kargarfard M, Chitsaz A, Azizi Abarkoohi S. Effect of a therapeutic exercises course in the water on the balance of patients with Parkinson's. J Isfahan Med School. 2012; 30(178): 1- 10.
10. Ferreira J. 2018. Risk of Drowning in People With Parkinson’s Disease. Movement Disorders, 33(9): 1507-1509.
11. Alimohamadi Y, Sepandi M. (2022). Sample Size in Animal Studies (The number of laboratory animals in a Research study). Iranian Journal of Medical Microbiology, 16(2): 173-6.
12. Khalaj A, Ahmadi R. (2016). The effect of treadmill exercise on catalepsy from reserpine-induced Parkinson model in diabetic male rat. KAUMS Journal (FEYZ), 20(5): 397-404.
13. Hubrecht RC, Kirkwood J. (2010). The UFAW handbook on the care and management of laboratory and other research animals. John Wiley & Sons,
14. Ma Q, Zhao H, Tao Z, Wang R, Liu P, Han Z, et al. MicroRNA-181c exacerbates brain injury in acute
15. Jafari F, Doulah A, Rafieirad M (2020). Effect of oleuropein and swimming practice on motor disorder induced by 6- hydroxydopamine toxin in mature male rats. J Bas Res Med Sci, 7(1): 50-60.
16. Tillerson JL, Caudle WM, Reveron ME, Miller GW. (2003). Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease. Neuroscience, 119(3): 899-911.
17. Kim Y, Kim M, Kim H, Kim K. (2009). Effect of lavender oil on motor function and dopa-mine receptor expression in the olfactory bulb of mice. J Ethnopharmacol, 125: 31-5.
18. Winter B, Breitenstein C, Mooren FC, Voelker K, Fobker M, Lechtermann A, et al. (2007). High impact running improves learning. Neurobiol Learn Mem, 87(4): 597-609.
19. Chen H, Zhang SM, Schwarzschild MA (2005). Hernán MA, Ascherio A. Physical activity and the risk of Parkinson’s disease. Neurology,64(4): 664-9.
20. Johnson RA, Rhodes JS, Jeffrey SL, Garland T, Mitchell GS. (2003. Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running. Neuroscience, 121(1): 1-7. doi: 10.1016/s0306- 4522(03)00422-6
21. Vučković MG, Li Q, Fisher B, Nacca A, Leahy RM, Walsh JP, et al. (2010). Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹⁸F] fallypride, 25 (16): 2777-84.
22. Goodwin VA, Taylor RS, Taylor AH, Campbell JL. (2008). The effectiveness of exercise interventions for people with Parkinson's disease: A systematic review and meta-analysis. Mov Disord, 23(5):631-40. doi: 10.1002/mds.21922
23. Bambaei chi E, Mumbai Bombay, Rahnama N, Mahmoudi F. (2013). effect of combined and balance exercises on balance, flexibility and motor performance of patients with Parkinson’s disease. Sports Med Stud, 5(14):45-58.