Potential of magnetite nanoparticles with biopolymers loaded with gentamicin drug for bone cancer treatment
Ehsan Nassireslami
1
(
Toxicology Research Center, AJA University of Medical Sciences, Tehran; Iran
)
Mehdi Motififard
2
(
Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
)
Bahareh Kamyab Moghadas
3
(
Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
)
Zahra Hami
4
(
Toxicology Research Center, AJA University of Medical Sciences, Tehran; Iran
)
Amir Jasemi
5
(
Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
)
Amin Lachiyani
6
(
Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
)
Reza Shokrani Foroushani
7
(
Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
)
Saeed Saber-Samandari
8
(
New Technology Research Center, Amirkabir University of Technology, Tehran, Iran
)
Amirsalar Khandan
9
(
New Technology Research Center, Amirkabir University of Technology, Tehran, Iran
)
Keywords: Magnetic nanoparticles, magnetization, Drug delivery system, Malignant Tumor,
Abstract :
Objective (s) Due to the natural bone microstructure, the design and fabrication of porous ceramic scaffold nanocomposite materials coated with thin layer of a natural polymer can provide an ideal scaffold for bone tissue engineering. This study aimed to fabricate multi-component porous magnetic scaffolds by freeze- drying (FD) technique using a gelatin polymer layer coated with a gentamicin drug. Materials and Methods: Magnetic nanoparticles (MNPs) can be manipulated and controlled by an external magnetic field gradient (EMFG) that is inherent in the magnetic field's permeability within human tissues. In the present work, unlike the usual ceramic/polymer composite scaffold, the ceramic components and the magnet were placed together in the reaction medium from the beginning, and bioceramics were replaced in the composite polymer network and then coated with a drug-loaded polymer. To evaluate the morphology of the magnetic scaffold, scanning electron microscopy (SEM) was utilized to evaluate the microstructure and observe the porosity of the porous tissue. Results and Discussion: After analyzing the SEM images, the porosity of the scaffolds was measured, which was similar to the normal bone architecture. Also, the porosity value increased from 55% to 78% with addition of MNPs to the based matrix. Conclusion: The results of this study showed that gentamicin-gelatin-coated on porous ceramic-magnet composite scaffolds could be used in bone tissue engineering and apply for treatment of bone tumors, because of their similarity to the bone structure with good porosity.