تاثیر 16 هفته محدودیت کالریک بر سطوح آیریزین سرم و شاخص مقاومت به انسولین در زنان چاق کم تحرک
محورهای موضوعی : میکروبیولوژی مواد غذاییاعظم رمضانخانی 1 , رحمان سوری 2
1 - دکتری تخصصی فیزیولوژی ورزش، دانشگاه تهران، تهران، ایران
2 - دانشیار گروه فیزیولوژی ورزش، دانشگاه تهران، تهران، ایران
کلید واژه: آیریزین, زنان چاق کم تحرک, شاخص مقاومت به انسولین, محدودیت کالری,
چکیده مقاله :
مقدمه: آیریزین مایوکاین جدیدی است که از پروتئین غشایی آزاد شده و تأثیرات مثبتی بر متابولیسم دارد. هدف از پژوهش 5 حاضر، بررسی تأثیر محدودیت کالری بر سطوح آیریزین سرم و شاخص مقاومت به انسولین در زنان چاق کم تحرک می باشد. سال؛ 41/40±4/٥3 انحراف استاندارد ± نفر از زنان مراجعه کننده به خانههای سلامت غرب تهران (میانگین 20 : مواد و روشها 14/٦±٦9/٧ نفر) قرار گرفتند. افراد گروه محدودیت 10 نفر) و کنترل ( 10( کیلوگرم)، به طور تصادفی در دو گروه محدودیت کالری ٦ % کمتر از انرژی محاسبه شده روزانه دریافت نمودند. میزان آیریزین سرم، گلوکز و انسولین و مقاومت به انسولین 2٥ کالری، در دوره مداخله، HOMA با روش هفته مداخله اندازهگیری گردید. 1٦ - (شاخص مقاومت به انسولین) قبل و بعد از IR (نسبت دور کمر به دور لگن)، آیریزین سرم، گلوکز ناشتا، انسولین ناشتا WHR ، (نمایه توده بدن) BMI یافتهها: کاهش معناداری در وزن، HOMA و HOMA - در گروه محدودیت کالری مشاهده گردید. بین تغییرات آیریزین سرم با تغییرات وزن، IR همبستگی WHR - و IR p معناداری مشاهده گردید ( <0.05.) HOMA و WHR ،BMI نتیجه گیری :همبستگی معناداری بین سطوح آیریزین سرم با هفته محدودیت کالری بر 1٦ - وجود دارد. IR کاهش میزان آیریزین سرم و شاخص مقاومت به انسولین در زنان چاق کم تحرک مؤثر است.
Introduction: Irisin is a new adipokine that is released from membrane protein FNDC5 and has positive effects on metabolism. The aim of this study was to survey the effects of caloric restriction on serum irisin levels and insulin resistance index in obese sedentary women. Materials and Methods: Twenty women (Mean± SD: 41.40±4.53 years; 76.69±6.14 Kg) who referred to home health of west of Tehran were divided into two groups; caloric restriction group (n=10) and control group (n=10). The calorie restriction group, in the intervention period, received 25% less than the estimated daily energy requirement. Serum irisin, glucose, insulin levels and insulin resistance using HOMA-IR were measured before and after 16 weeks. Results: Weight, BMI (body mass index), WHR (waist to hip ratio), serum irisin, fasting glucose, fasting insulin and HOMA-IR were decreased significantly in the caloric restriction group. Significant correlation were observed between changes of serum irisin levels with changes of body weight, WHR, HOMA-IR, fasting glucose and fasting insulin levels (p<0.05). Conclusion: There is a significant correlation between serum irisin levels with BMI, WHR and HOMA-IR. 16 weeks of caloric restriction is effective in reduction of serum irisin levels and insulin resistance in obese sedentary women.
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