Synthesis and Biological Activity of a New Schiff Base Ligand Pyridazine Based

Subject Areas : Journal of Chemical Health Risks

M. H. Fekri ¹ , M. Darvishpour ² , H. Khanmohammadi ³ , M. Rashidipour ⁴

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Received: 2014-02-22 Accepted : 2018-10-29 Published : 2013-12-01

Keywords: antibiotic, Schiff base, Di-azo compound, Pyridazine, O-vanilin,

Abstract :

In this work 3, 6-bis (2-[2-sulfanyl-ethylimino)-methyl]-4-(4-nitro-phenylazo)-3-metoxy-phenol) pyridazine (2) was prepared and its antibacterial properties have studied. The structures of all the newly synthesized compounds have been comfirmed by elemental analysis, IR, 1H-NMR. Anti bacterial effects of compounds (1 and 2) have been studied. Following concentrations of materials were used: a=0.005 g/ml and b=0.01 M. Study was done on two strains of S.aureus and E.coli that experiments were done in Trypticase Soy Broth (TSB) and Nutrien Agar (TSB; Difco Laboratory). It is likely that these synthetic materials exert higher antibacterial effect on gram positive bacteria in comparison with gram negative.

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