پیش‌تغلیظ مقادیر ناچیز کلونازپام در نمونه‌های آبی با نانولوله¬های‌کربنی کربوکسیل‌دارشده
نرگس صالحی
1
(
دانش‌آموخته مقطع دکترا گروه شیمی، دانشکده شیمی دارویی، دانشگاه علوم پزشکی آزاد اسلامی تهران، تهران، ایران.
)
علی مقیمی
2
(
دانشیار گروه شیمی، دانشکده شیمی دارویی، دانشگاه علوم پزشکی آزاد اسلامی تهران، تهران، ایران.
)
میلاد ابنیکی
3
(
دانش‌آموخته مقطع دکترا گروه پژوهشی رزین و افزودنی‌ها، پژوهشگاه علوم و فناوری رنگ، تهران، ایران.
)
کلید واژه: نانولوله¬های کربنی کربوکسیل‌دارشده, طیفنور¬سنجی مرئی و فرابنفش, داروی کلونازپام.,
چکیده مقاله :
در این پژوهش، با روش جديد استخراج فاز جامد پخشی مقدارهای ناچیز پساب‌های دارویی بهعنوان شاخص داروی کلونازپام در نمونه‌های آبی با نانولوله‌های کربنی کربوکسیل‌دارشده ارائه و اندازه‌گیری مقدار دارو با طیفسنجی مرئی و فرابنفش در نمونه‌های حقیقی انجام شد. نانولوله‌های کربوکسیل‌دارشده با طیفسنجی فروسرخ تبدیل فوریه (FTIR)، پراش پرتو ایکس (XRD) و میکروسکوپ الکترونی روبشی (SEM) شناسایی شدند. در اين روش، يك سامانه دو فازي به‌کارگرفته شد كه در آن فاز دهنده نمونه‌هاي آبي حاوي کلونازپام و فاز گيرنده نانولوله‌هاي‌كربني کربوکسیل‌دارشده بودند. آزمايشها در دو مرحله استخراج از نمونه‌هاي آبي و واجذب داروی کلونازپام با حلال آمونیاک انجام و نمونه‌هاي واجذب‌شده براي تجزیه بيشتر با دستگاه طیفسنجی مرئی و فرابنفش بررسی شدند. اين روش ارزان، ساده و سريع است. همچنین، روشی حساس و مطمئن براي استخراج و پيشتغليظ و اندازهگيري مقادیر ناچیز کلونازپام به‌حساب می‌آید. عامل‌های مؤثر بر استخراج مانند pH، مقدار و نوع حلال شوینده و زمان استخراج بررسی شدند. فاکتور تغلیظ، مقدار حد تشخیص روش (LOD) و انحراف استاندارد نسبی به ترتیب برابر با 30، 1- mg.l2/1 و 4/2 درصد بهدست آمدند.
چکیده انگلیسی :
In This research, a new technique was provided for solid phase extraction of small amounts of pharmaceutical effluents as an indicator of clonazepam drug in aqueous samples by carboxylated carbon nanotubes and its determination by visible and ultraviolet spectroscopy in real samples. Carboxylated carbon nanotubes were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscope (SEM). This technique was a two-phase system in which the donor phase was "water samples" containing clonazepam and the receiver phase was "carboxylated carbon nanotubes". Experiments were performed in two stages of extracting water samples and desorbing clonazepam drug using ammonia solvent and the desorbed samples were submitted to UV-Vis spectrophotometer for further analysis. This method was cheap, simple, and fast. Also, a sensitive and reliable method was used to extract, pre-concentrate and determine small amounts of clonazepam. The parameters affecting the extraction such as pH, the amount and type of eluent solvent, and the extraction time were investigated. The concentration factor, the detection limit of the method (LOD), and the relative standard deviation were 30, 1.2 µg.l-1, and 2.05%, respectively.
[1] Ståhl Y, Persson A, Petters I, Rane A, Theorell K, Walson P. Kinetics of clonazepam in relation to electroencephalographic and clinical effects. Epilepsia. 1983;24(2):225–231. doi: 10.1111/j.1528-1157.1983.tb04883.x
[2] Moghimi A, Abniki M, Qomi M. Removal of lead (II) using modified octadecyl silica nanomagnetic disks with dioctyl phthalate by atomic absorption spectroscopy. Journal of Quantum Chemistry and Spectroscopy [persian]. 2020;10(33):42–48.
[3] Moghimi A, Abniki M, Yari M. Effective removal of mercury (II) from environmental aqueous samples using carbon nanotubes carboxylated by dispersive solidphase extraction method. Journal of Environmental Geology. 2020;52:15–22.
[4] Moghimi A, Abniki M. Dispersive solid-phase extraction for preconcentration of colored effluent in aqueous samples using magnetic carbon nanotubes modified with chitosan. Journal of Quantum Chemistry and Spectroscopy. 2020;9(32):60–68.
[5] Cooper G. Therapeutic uses of botulinum toxin. Totowa: Humana Press; 2007.
[6] Abniki M, Moghimi A. Synthesis of chitosan functionalized magnetic carbon nanotubes for dispersive solid‐phase extraction of bromocresol green. Micro & Nano Letters. 2021;16:455-62. doi: 10.1049/mna2.12067
[7] Moghimi A, Qomi M, Yari M, Abniki M. Solid phase extraction of Hg (П) in water samples by nano-Fe3O4 encapsulated-dioctylphthalate and linked-diethylenetriamine. Int J Bio-Inorg Hybr Nanomater. 2019;8(4):159-168.
[8] Moghimi A, Abniki M. Removal and measurement of bromocresol purple dye in aqueous samples by β-cyclodextrin-modified magnetic carbon nanotube with dispersive solid-phase extraction technique. Journal of Color Science and Technology. 2022;15:301-315. doi: 20.1001.1.17358779.1400.15.4.4.5
[9] Abniki M, Moghimi A, Azizinejad F. Synthesis of calcium‐layered double hydroxide based nanohybrid for controlled release of an anti‐inflammatory drug. Chinese Chemical Society Taipei. 2020;68:343-52. doi: 10.1002/jccs.202000008
[10] Moghimi A, Abniki M. The dispersive solid-phase extraction of fluoxetine drug from biological samples by the amine-functionalized carbon nanotubes with HPLC method. Chemical Methodologies. 2021;5:250-8. doi: 10.22034/chemm.2021.128586
[11] Abniki M, Azizi Z, Poorebrahim S, Moniri E. Development of p-amino acetanilide functionalized multi-walled carbon nanotubes as an effective carrier for lansoprazole release. Biomedical physics & engineering express. 2023;9(4):37167956. doi: 10.1088/2057-1976/acd459
[12] Abniki M, Moghimi A, Azizinejad F. Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release. Journal of the Serbian Chemical Society. 2020;85:1223-35. doi: 10.2298/JSC191011004A
[13] Parsayi Arvand M, Moghimi A, Abniki M. Extraction of alprazolam in biological samples using the dispersive solid‐phase method with nanographene oxide grafted with Α‐pyridylamine. IET Nanobiotechnology. 2023;17:69-79. doi: 10.1049/nbt2.12105
[14] Moghimi A, Abniki M. dispersive solid-phase extraction for bromocresol green removal with β-cyclodextrin functionalized magnetic nanotubes. Russian Journal of Physical Chemistry B. 2021;15:S130-S9. doi: 10.1134/S1990793121090128
[15] Moghimi A, Abniki M. Preconcentration and separation of ultra-trace Cu(II) with disks of octadecyl silica membrane modified nano-Fe3O4-encapsulated-dioctyl phthalate and linked-diethylenetriamine. Advanced Journal of Chemistry-Section A. 2021;4:78-86. doi: 10.22034/ajca.2021.260252.1230
[16] Moghimi A, Abniki M, Khalaj M, Qomi M. Construction of modified nanotube carbon carboxyl by new method and application in dispersive solid phase extraction for preconcentration of Ni2+. Revue Roumaine de Chimie. 2021;66(6):493-507. doi: 10.33224/rrch.2021.66.6.02
[17] Shojaei M, Moghimi A, Abniki M. Dispersive solid-phase extraction for preconcentration of Amlodipine in aqueous samples using Fe3O4@MWCNT- β cyclodextrin compositeand determinated. Quantum Chemistry and Spectroscopy. 2021;11(35):43-55.
[18] Moghimi, A. Preconcentration of Zn(II) from sample water by phenyl-iminodiacetic acid grafted multiwalled carbon nanotubes. Journal of Chemical Health Risks. 2012;2(3):28-41. doi: 10.22034/JCHR.2018.544002
[19] Abniki M, Moghimi A. Removal of Cd(II) ions from water solutions using dispersive solid-phase extraction method with 2-aminopyridine/graphene oxide nanoplates. Current Analytical Chemistry. 2022;18:1070-1085. doi: 10.2174/1573411018666220505000009
[20] Moghimi A, Poursharifi MJ. Perconcentration of trace Cr(III) using octadecyl silica membrane modified N, N-disalicylideneethylenediamine. Asian Journal of Chemistry, 2011;23(9):3870-3874.
[21] Tajodini N, Moghimi A. Spectrophotometric study of W(VI)-G lycinamide complex formation. Asian Journal of Chemistry. 2011;23(9):4186.
[22] Behrouzinia S, Zand M, Namdar A, Rahimi H, Moghimi A. The effect of operational parameters on the output power of copper vapor laser with small-bore tube. International Journal of Fundamental Physical Sciences. 2011;1 (3):67-72. doi: 10.14331/ijfps.2011.330015
[23] Karimnezhad K, Moghimi A, Adnan R, and Abniki M. An alternative method of dispersive solid‐phase extracting Hg (II) from environmental aqueous solutions using carboxylic functionalized carbon nanotubes. Micro & Nano Letters. 2022;18:e12150. doi: 10.1049/mna2.12150
[24] Ghammamy S, Khorsandtabar S, Moghimi A, Sahebalzamani H. Oxidation of some organic diols with trialkylammonium fluorochromates(VI), R3NH[CrO3F] (R= CH3, C2H5, C3H7 and C4H9) at room temperature and under microwave condition. Journal of the Mexican Chemical Society. 2009;53(2):41-43. doi: 10.29356/jmcs.v53i2.1003
[25] Moghimi A. Solid Phase Extraction of Cr(III) from natural water by modified nanopolyacrylonitrile fiber. World Applied Sciences Journal. 2011;12(12):2252-2259.
[26] Makipour P, Moghimi A, Ghiasi R. Preconcentration and spectrophotometric determination of copper (II) using octadecyl silica membrane disks modified by 1-nitroso-2-naphthol-3,6-disulfonic acid. Oriental Journal of Chemistry. 2010;26(3):797.
[27] Moghimi A. Preconcentration ultra trace of Cd(II) in water samples using dispersive liquid-liquid microextraction with salen(N,N′-Bis(salicylidene)-ethylenediamine) and determination graphite furnace atomic absorption spectrometry. Journal of the Chinese Chemical Society. 2008;55(2):369-376. doi: 10.1002/jccs.200800054
[28] Abniki M, Moghimi A. Nanomagnetic chitosan/β-cyclodextrin for dispersive solid phase extraction of trace desipramine drug. Materials Chemistry and Physics, 2024;316:129117.
doi: 10.1016/j.matchemphys.2024.129117
[29] Dahaji RRM, Moghimi A, Shahbazi H, Faraji H, Aziznejad F. Preparation of modified multiwalled carbon nanotubes (l-Arg-CS/MWCNTs-COOH/Fe3O4) as sorbent for dispersive solid phase extraction of Cu(II), Pb(II) and Cd(II) in wastewater samples. Revue Roumaine de Chimie. 2023;68(10–12):495–505. doi: 10.33224/rrch.2023.68.10-12.01
[30] Moghimi A. Separation and extraction of Co(II) using magnetic chitosan nanoparticles grafted with β-cyclodextrin and determination by FAAS. Russian Journal of Physical Chemistry A. 2014;88:2157–2164. doi: org/10.1134/S0036024414120024
[31] Moghimi A, Yousefi Siahkalrodi S. Extraction and determination of Pb(II) by organic functionalisation of graphenes adsorbed on surfactant coated C18 in environmental sample. Journal of Chemical Health Risks. 2013;3(3):1-12. doi: 10.22034/jchr.2018.544032
[32] Moghimi A, Abdouss M. Extraction of Co(II) by isocyanate treated graphite oxides (iGOs) adsorbed on surfactant coated C18 before determination by FAAS. International Journal of Bio-Inorganic Hybrid Nanomaterials. 2013;2(1):319-327.
[33] Salehi N, Moghimi A, Shahbazi H. Magnetic nanobiosorbent (MG-Chi/Fe3O4) for dispersive solid-phase extraction of Cu(II), Pb(II), and Cd(II) followed by flame atomic absorption spectrometry determination. IET. Nanobiotechnology. 2021;15:575-584. doi: 10.1049/nbt2.12025
[34] Salehi N, Moghimi A, Shahbazi H. Preparation of cross-linked magnetic chitosan with methionine-glutaraldehyde for removal of heavy metals from aqueous solutions. International Journal of Environmental Analytical Chemistry. 2022;102:2305-2321. doi: 10.1080/03067319.2020.1753718
[35] Salehi N, Moghimi A. Synthesis and identification of magnetic nickel oxide nanoparticles for the magnetic solid phase extraction of gemfibrozil and its determination by UV-Vis spectrometer. Applied Chemistry Today. 2022;102:2305-2321. doi: 10.22075/CHEM.2023.29235.2127
[36] Mahdavi Ghajari S, Allah Gholi Ghasri MR, Sedaghat S, Adhami F, Habibi S. Green synthesis of silver nanoparticles mediated using Mentha spicata leaf extract and electrospun silver/polyamide 6 nanofibers preparation for removal of copper ions from aqueous medium and isotherm and kinetics adsorption study. Journal of applied research in chemisry. 2024;2(17):59-74. doi: 10.30495/JACR.2022.1968287.2060.
[37] Nie P, Min C, Song H-J, Chen X, Zhang Z, Zhao K. Preparation and tribological properties of polyimide/carboxyl-functionalized multi-walled carbon nanotube nanocomposite films under seawater lubrication. Tribology Letters. 2015;58(1):7. doi: 10.1007/s11249-015-0476-7
[38] Mirzaei N, Rezaei V, Aibaghi B. Preconcentration and determination of diazepam in pharmaceutical and biological samples by graphene oxide based on dispersive solid phase microextraction. Applied Chemistry Today. 2019;14:21-32. doi: 10.22075/CHEM.2018.13851.1343.
[39] Alizadeh R, Salami M, Seidi S. A silica fiber coated with a ZnO-graphene oxide nanocomposite with high specific surface for use in solid phase microextraction of the antiepileptic drugs diazepam and oxazepam. Microchimica Acta. 2018;185(6):312. doi: 10.1007/s00604-018-2850-2