Preconcentration of trace clonazepam in water samples using carboxylated carbon nanotubes as sorbent
Narges Salehi
1
(
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Islamic Azad University of Medical Sciences, Tehran, Iran
)
ali moghimi
2
(
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Islamic Azad University of Medical Sciences, Tehran, Iran
)
milad abniki
3
(
Department of Resins and Additives, Institute for Color Science and Technology
)
Keywords: : Carboxylated carbon nanotubes (MWCNT-COOH), UV-Vis spectrophotometry, Clonazepam drug.,
Abstract :
In This research, a new technique was provided for solid phase extraction of small amounts of pharmaceutical effluents as an indicator of clonazepam drug in aqueous samples by carboxylated carbon nanotubes and its determination by visible and ultraviolet spectroscopy in real samples. Carboxylated carbon nanotubes were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscope (SEM). This technique was a two-phase system in which the donor phase was "water samples" containing clonazepam and the receiver phase was "carboxylated carbon nanotubes". Experiments were performed in two stages of extracting water samples and desorbing clonazepam drug using ammonia solvent and the desorbed samples were submitted to UV-Vis spectrophotometer for further analysis. This method was cheap, simple, and fast. Also, a sensitive and reliable method was used to extract, pre-concentrate and determine small amounts of clonazepam. The parameters affecting the extraction such as pH, the amount and type of eluent solvent, and the extraction time were investigated. The concentration factor, the detection limit of the method (LOD), and the relative standard deviation were 30, 1.2 µg.l-1, and 2.05%, respectively.
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