One-pot Synthesis of Polysubstituted Indolizine Derivatives

Piltan, Mohammad; Zarei, Seyed Amir; Saydi, Hassan; Shahvelayati, Ashraf Sadat

Manuscript ID : 523919 Visit : 255 Page: 85 - 90

20.1001.1.20083815.2016.10.3.9.7

Article Type: Original Research

One-pot Synthesis of Polysubstituted Indolizine Derivatives

Subject Areas : Polymer

Mohammad Piltan ¹ , Seyed Amir Zarei ² , Hassan Saydi ³ , Ashraf Sadat Shahvelayati ⁴

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Received: 2016-07-22 Accepted : 2016-07-22 Published : 2016-07-01

Keywords:

Abstract :

An efficient approach to the synthesis of 1,2,3-trisubstituted indolizines is described via one-pot reactions of pyridine and dialkyl acetylendicarboxylate in the presence of ethyl 2-chloroacetoacetate in MeOH at room temperature. The corresponding 1, 2, 3-trisubstituted indolizines may be useful building blocks for the construction of complex indolizine derivatives.

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One-pot Synthesis of Polysubstituted Indolizine Derivatives