Preparation of Novel Thermo-sensitive Polymer/βCD/WS2 Nano-carriers for invitro Drug Release of Tamoxifen in the Presence and Absence of Near-Infrared (NIR) Laser

Subject Areas : Polymer

Abbas Bohloli ¹ , Maryam Daghighi Asli ² , Elham Moniri ³ , Azar Bagheri ⁴

1 - Department of Chemistry, Central Tehran Branch, Islamic Azad University Tehran, Iran
2 - Department of Chemistry, Central Tehran Branch, Islamic Azad University Tehran, Iran
3 - Department of Chemistry, Central Tehran Branch, Islamic Azad University Tehran, Iran
4 - Department of Chemistry, Central Tehran Branch, Islamic Azad University Tehran, Iran

Received: 2022-12-10 Accepted : 2022-12-10 Published : 2023-01-01

Keywords:

Abstract :

In this work, two novel N-isopropylacrylamide (NIPAA)/Beta-cyclodextrin (β-CD)/WS2 and NIPAA/N, Ndimethyl acrylamide (DMAA)/WS2/βCD nanocarriers were prepared for in vitro tamoxifen drug release inthe absence and presence of Near-Infrared (NIR) laser. The characterization of resulting nanocarriers wascarried out using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), field-emissionscanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA). To study the effect oftemperature on drug release for chemotherapy, tamoxifen drug release was comparatively evaluated at threedifferent temperatures (25, 37, and 50°C) with pH 7.4 in the absence of a NIR laser. It was found thattamoxifen release from the synthesized nanocarriers at 50°C was significantly greater than that at 25 and37°C. To investigate the effect of laser light on drug release for chemo-photothermal therapy, the in vitrorelease tests were carried out at 37°C with a NIR laser light and with a power density of 1 W/cm2for 5 min.The increase of tamoxifen release after a laser light was 29.8% and 48.4%for NIPAA/βCD/WS2 andNIPAA/DMAA/βCD/WS2 samples, respectively. Thus, the combination of chemo/photothermal therapy hada synergistic effect on the drug release of tamoxifen. Furthermore, the total drug release ofNIPAA/DMAA/βCD/WS2 was greater than that of NIPAA/βCD/WS2 nanocarrier. Furthermore, the kineticrelease data were analyzed using Zero-order, First-order, Ritger-Peppas, and Higuchi models which followedthe zero-order kinetic release model. Also, good stability was observed for tamoxifen in the drug releasesystem.

References:

[1]. Z. Kazemi, F. Marahel, T. Hamoule, B. M. Goodajdar, J. Appl. Chem. Res., 16, 30 (2022).
[2]. W. Zhang, Z. Guo, D. Huang, Z. Liu, X. Guo, H. Zhong, Biomater.,32, 8555 (2011).
[3]. S.K. Misra, P. Kondaiah, S. Bhattacharya, C. Rao, Small, 8, 131 (2012).
[4]. S. A. Nazarali, S. A. Narod, Breast Cancer: Targets and Therapy, 6, 29 (2014).

[5]. R. Abou-Jawde, T. Choueiri, C. Alemany, T. Mekhail, Clinical Therapeutics,25, 2121 (2003).
[6]. N. Shahabadi, M. Razlansari, A. Khorshidi, H. Zhaleh, Res. Chem. Intermed.,46, 4257 (2020).
[7]. S.M. Taimoory, A. Rahdar, M. Aliahmad, F. Sadeghfar, M.R. Hajinezhad, M. Jahantigh, P.
Shahbazi, J.F. Trant, J. Molec. Liq., 265, 96 (2018).
[8]. T. Arimidex,The Lancet Oncology,7, 633 (2006).
[9]. L. Li, W.-W. Yang, D.-G. Xu, J.Drug Target.,27, 423 (2019).
[10]. A. Ramazani, M. Abrvash, S. Sadighian, K. Rostamizadeh, M. Fathi, Res. Chem. Intermed.,44,
7891 (2018).
[11]. F. Bani, M. Adeli, S. Movahedi, M. Sadeghizadeh,RSC Adv.,6, 61141 (2016).
[12]. M. Abbasian, F. Mahmoodzadeh, R. Salehi, A. Amirshaghaghi, New J. Chem.,41, 12777
(2017).
[13]. Y. Liu, X. Ji, J. Liu, W.W. Tong, D. Askhatova, J. Shi, Adv.Funct.Mater.,27, 1703261 (2017).
[14]. D. Luo, K.A. Carter, D. Miranda, J.F. Lovell, Adv. Sci., 4, 1600106 (2017).
[15]. K. Yang, J. Wan, S. Zhang, B. Tian, Y. Zhang, Z. Liu, Biomater.,33, 2206 (2012).
[16]. S. Wang, X. Li, Y. Chen, X. Cai, H. Yao, W. Gao, Y. Zheng, X. An, J. Shi, H. Chen,
Adv.Mater.,27, 2775 (2015).
[17]. W. Yin, L. Yan, J. Yu, G. Tian, L. Zhou, X. Zheng, X. Zhang, Y. Yong, J. Li, Z. Gu,ACS
Nano,8, 6922 (2014).
[18]. M. Khafaji, M. Zamani, M. Golizadeh, O. Bavi, Biophys.Rev.,11, 335 (2019).
[19]. W.Z. Teo, E.L.K. Chng, Z. Sofer, M. Pumera, Chem. A Eur. J.,20, 9627 (2014).
[20]. R. Freeman, T. Finder, L. Bahshi, I. Willner, Nano Lett.,9, 2073 (2009).
[21]. M. Messner, S.V. Kurkov, P. Jansook, T. Loftsson, Inter.J.Pharmaceutics,387, 199 (2010).
[22]. S. Prabu, R. Rajamohan, K. Sivakumar, S. Mohamad, Polycom. Arom. Comp.,41, 992 (2021).
[23]. M.V. Rekharsky, Y. Inoue, Chem.Rev.,98, 1875 (1998).
[24]. L. Xi, C. Li, Y. Wang, Y. Gong, F. Su, and S. Li, J. Pharmaceutical Sci.,109, 2544 (2020).
[25]. H. Tian, Z. Tang, X. Zhuang, X. Chen, X. Jing, Prog. Polym.Sci.,37, 237 (2012).
[26]. M. Ghoochian, H.A. Panahi, S. Sobhanardakani, L. Taghavi, A.H. Hassani, Microchem. J.,145,
1231(2019).

[27]. M. Ghoochian, S. Sobhanardakani, H.A. Panahi, L. Taghavi, A. Hassani, J.Water
Wastewater,30, 49 (2019).
[28]. Y. Fu, W.J. Kao, Exp. Opin. Drug Deliv.,7, 429 (2010).
[29]. M. Pooresmaeil, H. Namazi, Int. J. Biol. Macromol.,162, 501 (2020).
[30]. A.I. Rezk, F.O. Obiweluozor, G. Choukrani, C.H. Park, C.S. Kim, Int. J. Biol. Macromol.,141,
388 (2019).

[31]. J.M. Unagolla, A.C. Jayasuriya, Eur. J.Pharmaceutical Sci.,114, 199 (2018).
[32]. N. Zirak, A.B. Jahromi, E. Salahinejad, Ceramics Int.,46, 508 (2020).
[33]. I.B. Pathan, C.M. Setty, Acta Pharmaceutica Sci., 53, 127(2011).
[34]. L.A.D. Silva, E.R. Cintra, E.C.P. Alonso, G.L. Alves, E.M. Lima, S.F. Taveira, M.S.S. da
Cunha-Filho, R.N. Marreto,J. Thermal Anal. Calorimetry,130, 1593 (2017).
[35]. H.S. Vaziri, A. Shokuhfar, S.S.S. Afghahi, Mater. Res. Express,7, 025034 (2020).
[36]. F. Yan, Z. Sun, J. Xu, H. Li, Y. Zhang, Microchimica Acta,187, 344 (2020).
[37]. Y. Qin, Y. Peng, W. Yang, Y. Wang, J. Cui, Y. Zhang, IOP Conf. Ser.: Mater. Sci. Eng., 770,
012079 (2019).
[38]. Y. Guo, S. Guo, J. Ren, Y. Zhai, S. Dong, E. Wang, ACS Nano,4, 4001 (2010).
[39]. J. Wang, Z. Guo, J. Xiong, D. Wu, S. Li, Y. Tao, Y. Qin, Y. Kong, Inter.J. Biolog.
Macromolec.,125, 941 (2019).
[40]. Y. Liu, Z. Lai, P. Yang, Y. Xu, W. Zhang, B. Liu, M. Lu, H. Chang, T. Ding, H. Xu, RSC
Adv.7, 43104 (2017).
[41]. H.R. Verma, K.K. Singh, T.R. Mankhand, Waste Management,60, 652 (2017).
[42]. P. Yan, A. Liu, Y. Chen, J. Wang, S. Ruan, H. Chen, J. Ding, Scientific Reports,5, 12587
(2015).
[43]. K.P. Sambasevam, S. Mohamad, N.M. Sarih, N.A. Ismail, Inter.J.Molec.Sci.14, 3671 (2013).
[44]. I. Shown, S. Banerjee, A. Ramchandran, K.E. Geckeler, C. Murthy, Macromolec.Symposia,287,
51 (2010).
[45]. K. Bauri, S.G. Roy, S. Arora, R.K. Dey, A. Goswami, G. Madras, P. De, J.Thermal
Anal.Calorimetry,111, 753 (2013).
[46]. H. Wei, X. Zhang, C. Cheng, S.X. Cheng, R.X. Zhuo, Biomater.,28, 99 (2007).
[47]. H.H. Shin, H.W. Choi, J.H. Lim, J.W. Kim, B.G. Chung, Nanoscale Res. Lett.,15, 1 (2020).
[48]. A.M. Alkafajy, and T.M. Albayati, Mater. Today Commun.,23, 100890 (2020).
[49]. M.L. Bruschi, Strategies to Modify the Drug Release from Pharmaceutical Systems, Woodhead
Publishing (2015).
[50]. C. Jacques, H. Hopfenberg, V. Stannett, Polym. Sci. Technol., 6, 73(1974).
[51]. N.L. Thomas, A. Windle, Polym.,23, 529 (1982).