Catalyst-free synthesis of aminothiazole derivatives in water
Subject Areas : Iranian Journal of Organic ChemistryMahboubeh Ghasemian Dazmiri 1 , Narges Ghasemi 2 , Annataj Noushin 3
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Keywords: Primary Amines, aminothiazole, Phosphonate, Phosphites, Activated acetylenic compound, Benzoylisothiocyanates,
Abstract :
Functionalized aminothiazole are generated from the reaction of dimethyl acetylenedicarboxylate, benzoylisothiocyanates, primary amines, hydrazonoyl chloride and triphenylphosphine in water. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.