A green and efficient method for the preparation of 3, 4-dihydropyrimidin-2(1H)-ones using quaternary ammonium- treated clay in water
Subject Areas :Soheil Sayyahi 1 , Sedigheh Jahanbakhshi 2 , Zahra Dehghani 3
1 - Chemistry Department, Mahshahr Branch, Islamic Azad University, Mahshahr 63519, Iran
2 - Chemistry Department, Omidieh Branch, Islamic Azad University, Omidieh, Iran
3 - Chemistry Department, Omidieh Branch, Islamic Azad University, Omidieh, Iran
Keywords: Biginelli reaction, Multicomponent reactions, organoclay, 3, 4-Dihydropyrimidin-2(1H)-ones,
Abstract :
The reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields