Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines

Subject Areas :

Abdolhassan Doulah ¹ , Hamid Sadeghian ²

1 - Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz
2 - Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

Received: 2016-05-25 Accepted : 2016-05-25 Published : 2011-05-01

Keywords: 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine, pyrimidothiadiazine, dimethylthiocarbamoylchloride, 15- lipoxygenase,

Abstract :

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.

References:

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Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines