The Effect of Aspirin on the World’s Pandemic COVID-19

Subject Areas : Biotechnological Journal of Environmental Microbiology

Masoumeh Heidaritajan ^{1 *} , Maryam Jafarian Anvar ² , Seyed Amirali Ghasemi ³

1 - گروه علوم پزشکی، دانشکده پزشکی ، دانشگاه گرجستان ، تفلیس ، گرجستان
2 - گروه پزشکی ، دانشکده علوم پزشکی ، دانشگاه علوم پزشکی گرجستان، تفلیس ، گرجستان
3 - گروه دندانپزشکی ، دانشکده دندانپزشکی ، دانشگاه علوم پزشکی گیلان ، رشت ، ایران

Received: 2022-08-21 Accepted : 2022-09-20 Published : 2022-03-01

Keywords: Keywords: Aspirin, Mechanism of Action, Effect, COVID-19,

Abstract :

Aspirin has become one of the most frequently used and cheapest drugs in medicine now. Since its first synthesis
in 1897, several medicinal roles and mechanisms of action of Aspirin have become apparent. Since its
emergence, the COVID-19 pandemic has been ravaging the medical and economic sectors even with significant
vaccination advances. In severe presentations, the disease of SARS-CoV-2 can manifest in life-threatening
thromboembolic and multi-organ repercussions provoking notable morbidity and mortality. Aspirin, due to
its well-known properties and multiple molecular targets, and ought to its extensive clinical use, has been
perceived as a potential therapeutic agent for COVID-19. Aspirin acts at multiple cellular targets to achieve its
anti-inflammatory and anti-platelet effects. Although initial promising clinical data describing aspirin’s role in
COVID-19 has appeared, evidence supporting its use remains fragile and premature. In this article, we highlight
the history of Aspirin, a novel mechanism of action, and its uses. Also included is a brief statement of emerging
new applications and principal mechanisms by which Aspirin inhibits acute inflammation and alters platelet
biology; therefore, hypothesized that Aspirin might prove highly beneficial as a novel therapeutic drug for combating
severe acute inflammation and thrombosis associated with the cytokine storm in COVID -19 patients.