Introduction: Liver fatty acid binding protein (L-AFBP) is a novel biomarker of liver disease. Liver enzymes levels are higher in the obese than the lean people; however the effect of intensive aerobic exercise (IAE) on liver enzymes in the obese and the lean people not well known. Thus the aim of the present study was to comparison of L-FABP concentration in the obese and lean men after one bout IAE. Material & Methods: Nine sedentary obese men (BMI: 33.7 ± 2.1 kg/m2; ± SD) and nine sedentary lean men (BMI: 17.6 ± 1.6 kg/m2; ± SD) volunteered to participate in this study. All the subjects were performed the Bruce test as the intensive aerobic exercise. Blood samples were taken before and immediately after the IAE. Results: The results showed that alanine aminotransferase (ALT) was higher in obese group than the lean group at the baseline (P<0.05). L-AFBP decreased and ALT and aspartate aminotransferase (AST) increased after the IAE in the both groups (P<0.05). By comparison, the results indicated that the increase of ALT was higher in the obese group than the lean group (P<0.05); however, for L-AFBP and AST no significant differences were observed between two groups. Conclusions: One bout IAE increases AST and ALT and decreases L-AFBP in the obese men same as lean men. پرونده مقاله

Introduction: The insulin resistance and subsequent pancreatic β cell failure that precedes the development of hyperglycemia is thus usually associated with obesity. Exercise training may improves these impairs, however, this is not well known. The aim of present study was to examine the effect of 8 weeks concurrent training on pancreatic β-cells function and insulin resistance in obese men. Material & Methods: Twenty three middle aged obese men (aged: 34.6 ± 8.8 years; ± SD) were randomly assigned to one of the concurrent training group (n=12) or control group (n=11). The concurrent group performed endurance and resistance training on the same days, 3 days a week for 8 weeks. The subjects in the control group were instructed to maintain their normal physical activity throughout the study. Results: The results indicated that fasting insulin (P=0.006), insulin resistance index (P=0.02), pancreatic β-cells function (P=0.04) decrease in the training group compare to the control group; however, fasting blood sugar has no significant change after the intervention (P=0.3). Conclusion: In summary, it seems that concurrent training utilized in this study improves insulin resistance and pancreatic β-cells function in obese men. پرونده مقاله