4-Amino-5-bromo-2-substituted-aminopyrimidines were successfully reacted with various isothiocyanates in the alkaline alumina under Microwave irradiation to achieve a group of reported 2- aminothiazolo[4,5-d]pyrimidine derivatives . These compounds also carried out a multicomponent condensation with carbondisulfid and alkylhalides to furnish a group of reported 2- alkylsulfanylthiazolo[4,5-d]pyrimidine derivatives. پرونده مقاله

Displacement reaction of 2,3-dichloroquinoxaline with secondary amines in boiling ethanol afforded it`s mono aminoquinoxaline derivatives. Further reaction of the latter compounds with sodium azide in warm dimethylsulfoxide achieved a group of 4-amino tetrazolo[1,5-a]quinoxaline derivatives. 1HNMR spectra of these compounds are discussed. پرونده مقاله

Reaction of 3,6-dichloropyridazine with hydrazine gave 1-(6-chloropyridazin-3-yl) hydrazine in high yield in ethanol at room temperature. Diazotization of the latter compound converted it to 6-chlorotetrazolo[1,5-b]pyridazine quantitatively in ice bath. 6-Chlorotetrazolo[1,5-b]pyridazine underwent a chlorine substitution is ethanol with amines at room temperature.The reaction mechanism and spectral data is discussed. پرونده مقاله

Treatment of 7-chloro-1-phenylpyrimido[4,5-e][1,3,4]thiadiazines with hydrazine in boiling ethanol gave corresponding7-hydrazinyl derivatives. Diazotization of the latter compounds acheived a mixture of 5H-tetrazolo[1',5':1,2]pyrimido[4,5-e][1,3,4]thiadiazine and 9H-tetrazolo[5',1':2,3]pyrimido[4,5-e][1,3,4]thiadiazines. Ratio of these two group of products determined by 1HNMR studies and no significant preference was observed for their formation. Efforts for separation of the products were unsuccessful and its reason is discussed. پرونده مقاله

Displacement reaction of 2,3-dichloroquinoxaline with secondary amines in boiling ethanol afforded it`s mono aminoquinoxaline derivatives. Further reaction of the latter compounds with sodium azide in warm dimethylsulfoxide achieved a group of 4-amino tetrazolo[1,5-a]quinoxaline derivatives. 1HNMR spectra of these compounds are discussed. پرونده مقاله

Three new inorganic-organic hybrid materials based on heteropolyoxometalates, [L-C6H14NO2]3[(PO4)Mo12O36].3H2O (1), [L-C5H10NO2]3[(PO4)W12O36].H2O (2), and [C2H7N2O]3[(PO4)W12O36]. 4H2O (3), where C6H14NO2, C5H10NO2, and C2H7N2O are protonated L-leucine, L-proline, and methylurea, respectively, have been synthesized and structurally characterized by some physico-chemical methods. Elemental analyses, IR, Raman, mass, UV, and 1H NMR spectroscopies of the title hybrid materials indicate that there are van der Waals interactions between O atoms of the heteropolyoxometalates and water molecules, as well as the N and O atoms of the amino acids and methyl urea moieties. The molecular structures of synthesized hybrid materials contain discrete entities of L-leucinium, L-prolinium or methyluronium and water molecules that surround every [(PO4)M12O36]3- anion, over the extended crystalline network. The observed bands in Raman spectra of 2 and 3 demonstrate that [(PO4)W12O36]3- anion retains its “Keggin structure”. Between pH =7 and pH =4 the characteristic bands of the Keggin anion [(PO4)M12O36]3−(M = Mo, W) appear at 210 and 260 nm in the UV spectra, respectively. پرونده مقاله

Some new 3-(alkylsulfanyl)- 7-chloro-1-phenyl-1H-pyridazino [4,3-e][1,3,4]thiadiazine were synthesized by treatment of the alkyl-2-phenylhydrazinecarbodithioates with 4-bromo-3,6-dichloropyridazine in alkaline acetonitril. Orientation of the reaction has been determined by X-Ray crystallography technique. The chlorine atom on the number 7 position of these products was replaced by secondary amines in reflux condition. پرونده مقاله

Reaction of 2, 3- dichlroquinoxaline with hydrazine in methanol at room temperature gave 1-(2-chloroquinoxalin-3-yl) hydrazine and after 24 hours. Condensation of 1-(2-chloroquinoxalin-3-yl) hydrazine with ethylorthoesters on their boiling carboxylic acids for 8 hours afforded a group of 4-Chloro- [1,2,4] triazolo[4, 3- a]quinoxaline derivatives. Stirring of 4-Chloro- [1,2,4]triazolo[4, 3- a]quinoxaline derivatives with amines for 2 hours in ethanol at room temperature afforded a group of 4-Amino- [1,2,4]triazolo[4, 3-a]quinoxaline derivatives. Solvent effect of methanol and chloroform on this reaction and the spectral data is discussed. پرونده مقاله

Condensation of some alkyl-2-phenylhydrazinecarbodithioates with 2-chloromethylbenzoylchloride in alkaline boiling acetonitrile afford a group of 7-(alkylsulfanyl)-9-phenyl-5H- benzo[f][1,3,4]thiadiazocin-10(9H)-ones. پرونده مقاله