In this study, CFD simulation of hydrothermal of a nanofluid in a microchannel under a magnetic field with spherical depressions and protrusions on hot and cold walls is investigated. The effects of increasing Hartman (Ha) and Reynolds numbers (Re) in various volume fraction (φ) are investigated. The governing equation by using single-phase model, finite volume method and SIMPLE algorithm are solved. Also it assumes the flow is laminar, steady-state and incompressible. The simulation are considered in ranges of 10 ≤ Re ≤150, 0 ≤ Ha ≤10, and 0 ≤ φ ≤0.03. The findings illustrate that in a certain Ha number, increasing in Re number and φ cause the Nu number increase. Also in a constant Re number, As the Ha number increases, the mean Nu number increases. Likewise, an increase in φ has enhanced heat transfer in all Re and Ha numbers. In a certain φ, as Ha number and Re number enhance, the Nu number increases. By enhancing thermal conductivity, the heat transfer increases. When Re=150, the percentage increase of heat transfer in φ=0.03 relative to pure fluid is %5.98. پرونده مقاله