Recently, Functionally Graded Scaffolds (FGSs) have attracted a lot of attention as bone replacements due to their gradient porosities as well as a bone structure. In present study titanium functionally graded scaffolds (FGSs) were fabricated by powder metallurgy route using Mg and carbamide as space holders. The arranged layers with 20, 40 and 60 Vol.% porosities were compacted in steel die using uniaxial pressure of 500 MPa before sintering in sealed quartz tubes at 1100 °C for 3 hours. Image analyzing results and scanning electron microscope (SEM) observations showed more regular shapes and sizes of pores in FGSs using Mg as a space holder compared to carbamide. The observed compressive strength and Young’s moduli of the FGSs having Mg as a space holder were in the range of 47- 160 MPa and 25-75 GPa , respectively which can be appropriate as bone replacements. The results of MTT assay showed that the values of proliferation rate were higher in samples produced using Mg. پرونده مقاله