This study investigates the synergistic impact of cadmium and arsenic co-exposure on diabetic rats, highlighting their intricate interplay within the context of diabetes. Male and female rats, induced with diabetes via streptozotocin, were exposed to cadmium chloride and arsenic trioxide. Blood glucose dynamics, organ histopathology, and vital functions were scrutinized to elucidate the toxicological consequences. Results revealed significant deviations in blood glucose levels, amylase concentrations, and kidney and liver functions, coupled with discernible impairments in vital organs. These findings underscore the formidable health risks posed by concurrent cadmium and arsenic exposure in diabetic individuals, emphasizing the urgent need for further research to unravel the underlying mechanisms and devise preventive measures. This study accentuates the necessity for continued exploration in this domain to mitigate the perilous consequences of such co-exposure, emphasizing the critical intersection of diabetes and heavy metal toxicity. پرونده مقاله