Introduction: Menopause is one of the most important events in a woman's life that affects their physical and mental aspects. The aim of this study was to investigate the physiological and psychological effects of high intensity interval trainings (HIIT) in aged ovariectomized rats. Methods: In this experimental study, 12 aged ovariectomized rats were randomly divided into two groups of six including HIIT and control. HIIT group received training for eight weeks, three sessions per week, and 9 interval (each interval 1 minute) with intensity of 90- 95% VO2max and one minute running between each interval with intensity of 50% VO2max. 24 hours after the last training session, weights, visceral fat mass, anxiety-like behaviors and depression were measured. To statistical analysis of data Shapiro- Wilk test, paired sample t- test and independent sample t-test were used (p≤ 0.05). Results: Body weight (p = 0.002), visceral fat mass (p = 0.001) and duration of immobilization (p = 0.001) in HIIT training group were significantly lower than control group and percentage of elapsed time in the open arm (p = 0.003), the percentage of number of entrance to open arms (p = 0.03) and aerobic power (p = 0.001) in the HIIT group was significantly higher than the control group. Conclusion: It seems that HIIT have positive effects on the physiological and psychological factors of aged ovariectomized rats. پرونده مقاله

Introduction: Although resistance training and resveratrol is recommended as a stimulant for muscle regeneration in healthy subjects their effects on cancer-related cachexia indices are unclear. This study aimed to investigate the effect of a course of resistance training with resveratrol supplement on PAX-7 and eMHC in Gastrocnemius muscle tissue of mice bearing colon cancer induced cachexia. Methods: This was an experimental study conducted on 20 six-week-old BALB/c mice implanted with CT-26 tumor. The mice were randomly divided into four groups: resistance training, resveratrol, resveratrol with resistance training, and control. The resistance training group performed 6 weeks of progressive resistance training, the resveratrol group received 100 mg/kg resveratrol per day. 48 hours after the last experimental session, the mice were sacrificed and PAX-7 and eMHC protein levels were measured using ELISA test through specimen taken from gastrocnemius muscles. Statistical test of one way ANOVA was used for data analysis. Results: PAX-7 level was significantly lower in resveratrol with resistance training group compared to control (P=0.009), resveratrol (P=0.005), and resistance training groups (P=0.002). eMHC was significantly lower in the resistance training group compared to the control (P=0.08), resistance training, and resveratrol groups (P=0.002). Conclusion: Resistance training was not an appropriate intervention for treating reduced muscular regeneration due to cachexia. However, regarding reducing effect of resveratrol supplementation with resistance training on PAX-7 level, it may be recommended to improve muscular regeneration. پرونده مقاله