Introduction: Myocardial infarction (MI) is the destruction and permanent and irreversible cell death of part of the cardiac muscle (myocardium) which occurs due to loss of blood flow to the heart. The condition disrupts individuals’ daily life and limits their performance. Evidence indicates the likely effect of exercise on increasing the capillary density of skeletal muscle and myocardium. Vascular endothelial growth factor (VEGF) and endostatin as well as their common receptors (Flt-1) are the most important factors involved in angiogenesis. Therefore, this research aimed to evaluate the effect of 6 weeks of interval training on the VEGF, Flt-1 and collagen 18 in rats with MI. Methods: 12 male Wistar rats with mean age of 10weeks and average weight of 250- 300 gr were infected with myocardial infarction and were assigned into two groups of (1) experimental (60 minutes of interval running on treadmill, each interval 4 minutes with the 60- 75 percent of Vo2max and 2 minutes of active rest at 50- 60 percent of Vo2max for four days in a week for a period of 6 weeks) and (2) control group (without any training). Gene expression was investigated by the PCR technique and Ejection fraction and Shortening fraction were investigated by echocardiograph. Data were analyzed by SPSS 18 using independent samples t-test (p≤0.05). Results: Results showed that low intensity interval training had a significant effect on increasing the expression level of Flt-1 (P=0.02) and VEGF (P=0.01) genes and no significant change in collagen 18 (P=0.34). Conclusion: The overall results of the study supported the role of low-intensity interval training in increasing the basic factors affecting the process of angiogenesis after MI. پرونده مقاله

Introduction: Myocardial infarction (MI) is the irreversible cell death caused by ischemia in parts of myocardium. Atrial and brain natriuretic peptides (ANP and BNP) are known as strong markers of myocardial infarction. This research aimed to evaluate the effect of precedent of six-week light intensity interval training (LIIT) on the ANP and BNP gene expression in rats after Myocardial Infarction. Method: Twelve Wistar male rats of 10 weeks old and mean weight 250-300gr were allocated in two groups with six Rats in each groups of 1. LIIT (60 minutes interval running on a treadmill, each cycle including four minutes of running with an intensity of 55-60% VO2max and two minutes of active recovery with a 45-50% VO2max intensity, three days a week for six weeks) and 2. control group (without any precedent of training). Real-time PCR was used to assess the expression of ANP and BNP genes in myocardium (after inducing MI By blocking left coronary artery by surgery). For statistical analysis of data independent sample t test (p≤0.05) was used. Results: Light intensity interval training has significant effect on decreasing the gene expression of ANP (p=0.01) and BNP (p=0.001) in rats after myocardial infarction. Conclusion: It appears that adaptation to light intensity interval training controls and moderates the secretion of cardiac hormones in rats after myocardial infarction. پرونده مقاله