Background: Obesity leads to various chronic conditions and investigating its causative factors is of health and clinical and significance to humans. Doing physical exercises regularly and consuming proper diet are frequently recommended for achieving health benefits and resolving the various complications of obesity. This study examined the question whether performing moderate intensity aerobic exercises combined with spirulina, a seaweed rich in probiotics and antioxidants, can improve the lipid profile, body composition and function in overweight women. Methods: We examined the associated variables linked to obesity in 20 volunteer women in a pre- and post-test design over eight weeks of intense aerobic exercises based on an established protocol, compared to the controls. We assessed cardiovascular endurance, and variables like lipid profile, weight, body mass index, and lean muscle mass in response to exercising plus spirulina consumption versus the controls. Results: The exercise combined with spirulina significantly reduced blood triglycerides and LDL while raising the HDL. The treatment significantly reduced the body weight, fat and BMI while increasing the muscle strength and Vo2max compared to those of the control group. Conclusions: Combining moderate intensity aerobic exercises with spirulina supplements significantly reduced the body weight, fat deposits, and BMI while increasing the muscle strength and Vo2max in overweight and obese women. پرونده مقاله