Poly Ethylene Glycol-Stearate polymer in the design of nano-drug delivery system for oral administration by curcumin
محورهای موضوعی : Journal of NanoanalysisMarzihe Shahbazi 1 , Elham Rostami 2 , maryam kolahi 3 , alireza kiasat 4
1 - Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 - Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 - Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
4 - Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
کلید واژه: Curcumin, Extraction, Drug release, Modification, Solid lipid nanoparticles,
چکیده مقاله :
In this work, Poly Ethylene Glycol- Stearate (PEG-SA) was used to prepare coated solid lipid nanoparticles (NPs) with loading curcumin extracted by Turmeric powder (cur-polymer coated-SLNs) by micro emulsification method. Evaluation of the release kinetic of prepared nanoparrticle was resulted. Particle size, zeta potential and polydispersity index were evaluated by Photon Correlation Spectroscopy (PCS). The particle size and zeta potential of cur PEG coated-SLNs had been measured as 153 nm. Differential scanning calorimetric indicated that the majority of curcumin loaded in PEG-NP was in amorphous state which is desirable for drug delivery. Drug entrapment efficiency (EE) was obtained 99%. The modification procedure led to a reduction in the zeta potential values, varying from -40.0 mV for the uncoated particles to -23 mV for that of (PEG-SA)-coated NP. FT-IR spectra and HPLC analysis of plain SLNs and pure curcumin exhibit no peak shifting and no loss of characteristic functional group peaks. Shape and surface morphology of particles were determined by transition electron microscopy and scanning electron microscopy that revealed spherical shape of nanoparticles. In vitro curcumin release of (PEG-SA)-coated SLNs and SLNs were showed the slight decrease performed for PEG-SA-SLNs one because of coating impact of covering layer.
[1] Üner M, Yener G (2007) Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. Int. J. Nanomed 2:289
[2] Müller RH, MaÈder K, Gohla S ) 2000( Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art Eur .J .Pharm .Biopharm 50:161-177
https://doi.org/10.1016/S0939-6411(00)00087-4
[3] Lingayat VJ, Zarekar NS, Shendge RS (2017) Solid lipid nanoparticles: a review. J. Nanosci. Nanotechnol 2:67-72
[4] Carbone C, Cupri S, Leonardi A, Puglisi G, Pignatello R) 2013( Lipid-based nanocarriers for drug delivery and targeting: a patent survey of methods of production and characterization. Pharm. Pat. Anal 2:665-677
https://doi.org/10.4155/ppa.13.43
[5] Schubert MA, Müller-Goymann CC (2003) Solvent injection as a new approach for manufacturing lipid nanoparticles-evaluation of the method and process parameters. Eur. J. Pharm. Biopharm 55:125-131
https://doi.org/10.1016/S0939-6411(02)00130-3
[6] Cassano R, Ferrarelli T, Mauro MV, Cavalcanti P, Picci N and Trombino S (2016) Preparation, characterization and in vitro activities evaluation of solid lipid nanoparticles based on PEG-40 stearate for antifungal drugs vaginal delivery. Drug Deliv 23:1047-1056
https://doi.org/10.3109/10717544.2014.932862
[7] Cassano R, Trombino S (2019) Solid Lipid Nanoparticles Based on L-Cysteine for Progesterone Intravaginal Delivery. Int. J. Poly.Sci 60:45-55
https://doi.org/10.1155/2019/8690145
[8] Khan I, Saeed K, Khan I (2019) Nanoparticles: Properties, applications and toxicities. Arab. J. Chem 12:908-931
https://doi.org/10.1016/j.arabjc.2017.05.011
[9] Banshoya K, Nakamura T, Tanaka T, Kaneo Y (2020) Coenzyme Q10-polyethylene glycol monostearate nanoparticles: an injectable water-soluble formulation. Antioxidants 9:86
https://doi.org/10.3390/antiox9010086
[10] Battaglia L, Gallarate M, Cavalli R, Trotta M (2010) Solid lipid nanoparticles produced through a coacervation method. J. Microencapsul 27:78-85
https://doi.org/10.3109/02652040903031279
[11] Trombino S, Russo R, Mellace S (2019) Solid lipid nanoparticles made of trehalose monooleate for cyclosporin-A topic release. J Drug Deliv Sci Technol 49:563-569
https://doi.org/10.1016/j.jddst.2018.12.026
[12] Yuan H, Miao J, Du YZ, You J, Hu FQ, Zeng S (2008) Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells. Int. J. Pharm 348:137-145
https://doi.org/10.1016/j.ijpharm.2007.07.012
[13] Prado-Audelo D, María L, Caballero-Florán IH, Meza-Toledo JA, Mendoza-Muñoz N, González-Torres M, Floran B, cortes H, Leyva-Gómez G (2019) Formulations of curcumin nanoparticles for brain diseases. Biomolecules 9:56
https://doi.org/10.3390/biom9020056
[14] Ghalandarlaki N, Alizadeh AM, Ashkani-Esfahani S (2014) Nanotechnology-applied curcumin for different diseases therapy. Biomed Res. Int 2014
https://doi.org/10.1155/2014/394264
[15] Baek JS, Cho CW (2017) Surface modification of solid lipid nanoparticles for oral delivery of curcumin: Improvement of bioavailability through enhanced cellular uptake, and lymphatic uptake. Eur. J. Pharm. Biopharm 117:132-140 https://doi.org/10.1016/j.ejpb.2017.04.013
[16] Maiti P, Paladugu L, Dunbar GL (2018) Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease. BMC Neurosci 19:1-18
https://doi.org/10.1186/s12868-018-0406-3
[17] Liu Z, Okeke CI, Zhang L, Zhao H, Li J, Aggrey, M O, Guo L (2014) Mixed polyethylene glycol-modified breviscapine-loaded solid lipid nanoparticles for improved brain bioavailability: preparation, characterization, and in vivo cerebral microdialysis evaluation in adult Sprague dawley rats. AAPS Pharm SciTech 15:483-496
https://doi.org/10.1208/s12249-014-0080-4
[18] Deljoo S, Rabiee N, Rabiee M (2019) Curcumin-hybrid nanoparticles in drug delivery system. Asian j. nanosci. mater 2:66-91
[19] Bocca C, Caputo O, Cavalli R, Gabriel L, Miglietta A, Gasco MR Phagocytic uptake of fluorescent stealth and non-stealth solid lipid nanoparticles. Int. J. Pharm 175:185-193
https://doi.org/10.1016/S0378-5173(98)00282-8
[20] Ganesan P, Ramalingam P, Karthivashan G, Ko YT, Choi DK (2018) Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases. Int. J. Nanomed 13:1569
https://doi.org/10.2147/IJN.S155593
[21] Garcia-Fuentes M, Prego C, Torres D, Alonso MJ (2005) A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly (ethylene glycol) as carriers for oral calcitonin delivery. Eur. J. Pharm. Sci 25:133-143
https://doi.org/10.1016/j.ejps.2005.02.008
[22] Damge C, Michel C, Aprahamian M, Couvreur P, JP Devissaguet JP (1990) Nanocapsules as carriers for oral peptide delivery. J. Control. Release 13:233-239
https://doi.org/10.1016/0168-3659(90)90013-J
[23] Garcia-Fuentes M, Alonso MJ, Torres D (2005) Design and characterization of a new drug nanocarrier made from solid-liquid lipid mixtures. J. Colloid Interface Sci 285:590-598
https://doi.org/10.1016/j.jcis.2004.10.012
[24] Garcia-Fuentes M, Torres D, Alonso MJ ) 2005 (New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin. Int .J. Pharm 296:122-132
https://doi.org/10.1016/j.ijpharm.2004.12.030
[25] Florence AT (1997) The oral absorption of micro-and nanoparticulates: neither exceptional nor unusual. Pharm. Res 14:259-266
https://doi.org/10.1023/A:1012029517394
[26] Subedi RK, Kang KW, Choi HK (2009) Preparation and characterization of solid lipid nanoparticles loaded with doxorubicin. Eur. J. Pharm Biopharm. 37:508-513
https://doi.org/10.1016/j.ejps.2009.04.008
[27] Garcıa-Fuentes M, Torres D, Alonso MJ (2003) Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules. Colloids Surf B Biointerfaces 27:159-168
https://doi.org/10.1016/S0927-7765(02)00053-X
[28] Singhvi G, Singh M )2011 ( In-vitro drug release characterization models. Int. J. Pharm. Sci. Res 2:77-84
[29] Costa P, Lobo JMS) 2001 (Modeling and comparison of dissolution profiles. Eur. J. Pharm. Biopharm 13:123-133
https://doi.org/10.1016/S0928-0987(01)00095-1
[30] Barzegar-Jalali M, Adibkia K, Valizadeh H, Shadbad, A. Nokhodchi MRS, Omidi Y, Somayeh H, Nezhadi Gh, Hasan M,) 2008( Kinetic analysis of drug release from nanoparticles. Int. J. Pharm. Pharm. Sci 11:167-177
https://doi.org/10.18433/J3D59T
[31] Varelas CG, Dixon DG, Steiner CA )1995( Zero-order release from biphasic polymer hydrogels. J. Control. Release 34:185-192
https://doi.org/10.1016/0168-3659(94)00085-9
[32] Li X, Lin X, Zheng L, Yu L, Lv F, Zhang Q, Liu W (2008) Effect of poly (ethylene glycol) stearate on the phase behavior of monocaprate/Tween80/water system and characterization of poly (ethylene glycol) stearate-modified solid lipid nanoparticles. Colloids Surf 317:352-359
https://doi.org/10.1016/j.colsurfa.2007.11.011
[33] Li X, Lin X, Zheng L, Yu L, Lv F, Zhang Q, Liu W (2008) Effect of poly (ethylene glycol) stearate on the phase behavior of monocaprate/Tween80/water system and characterization of poly (ethylene glycol) stearate-modified solid lipid nanoparticles. Colloids Surf, A Physicochem Eng Asp, 317: 352-359
https://doi.org/10.1016/j.colsurfa.2007.11.011
[34] Ramalingam P, Ko YT (2016) Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles. Colloids Surf B Biointerfaces 139:52-61
https://doi.org/10.1016/j.colsurfb.2015.11.050
[35] Zhang N, Ping QN, Huang GH, Xu WF ) 2005( Investigation of lectin-modified insulin liposomes as carriers for oral administration. Int. J. Pharm 294:247-259
https://doi.org/10.1016/j.ijpharm.2005.01.018
[36] Kashanian S, Azandaryani AH, Derakhshandeh K ) 2011 (New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell. Int. J. Nanomed 6:2393
https://doi.org/10.2147/IJN.S20849
[37] Jani P, Halbert GW, LangrIdge J, Florence AT Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol 42:821-826
https://doi.org/10.1111/j.2042-7158.1990.tb07033.x
[38] Lu X, Howard MD, Mazik M, Eldridge J, Rinehart JJ, Jay M, Leggas M (2008) Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants: optimization and in vitro characterization. AAPS J 10:133-140
https://doi.org/10.1208/s12248-008-9013-z
[39] Liu W, Hu M, Liu W, Xue C, Xu H, Yang X (2008) Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate. Int. J. Pharm 364:135-141
https://doi.org/10.1016/j.ijpharm.2008.08.013
