Synthesis and Characterization of Chitosan/ Soya Protein /clay nanocomposite bioFilm for the Release of the Drug
محورهای موضوعی : Journal of Nanoanalysisfatemeh Mirjalili 1 , Mahboobeh Mahmoodi 2 , fatemeh Sadeghian-Nodoushan 3 , Seyyed Ahmad Mirzababaieiy 4
1 - Department of material engineering,faculty of engineering,Islamic azad university Maybod beranch,Iran
2 - Department of Biomedical Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran | Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 - Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4 - Department of Biomedical Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran
کلید واژه: Chitosan , soya protein, valsartan, nano clay particle,
چکیده مقاله :
Soya protein is one of the most easily available biodegradable polymers. However, there are some drawbacks that limit its application. Recently, soya protein-based nanocomposite bio film has proven to be a promising option in improving properties. In this study, Chitosan/ Soya Protein /clay nanocomposite biofilm containing valsartan as a drug was fabricated by solvent mixing method. Then, the nano biofilm properties such as surface morphology, chemical structure, swelling ratio, degradation rate and the release rate of valsartan were measured. The results showed that, the formation of a chemical bond in the constituents along with a smooth monolithic and compact surface. In addition, the swelling and degradation tests indicated that, the addition of 0.1 g of clay nano particle to the biofilm resulted in an increasing in the swelling and biodegradation rate and with addition of 0.05 g of nano clay particle a significant decrease in the rate of degradation and swelling of the biofilm was archived. The drug release test results also showed that, no sever release by soya protein /chitosan/clay nano composite biofilm containing valsartan as well as the drug release indicated a uniform release of nano composite biofilms with 0% and 0.05% of nano clay particles. Then, MTT assay was evaluated, which showed no cytotoxicity results in any of the nano biofilms. Therefore, nano composite biofilms with 0% and 0.05% of nano clay may be a more suitable option for valsartan release through the nano composite bio film for lowering the blood pressure.
Soya protein is one of the most easily available biodegradable polymers. However, there are some drawbacks that limit its application. Recently, soya protein-based nanocomposite bio film has proven to be a promising option in improving properties. In this study, Chitosan/ Soya Protein /clay nanocomposite biofilm containing valsartan as a drug was fabricated by solvent mixing method. Then, the nano biofilm properties such as surface morphology, chemical structure, swelling ratio, degradation rate and the release rate of valsartan were measured. The results showed that, the formation of a chemical bond in the constituents along with a smooth monolithic and compact surface. In addition, the swelling and degradation tests indicated that, the addition of 0.1 g of clay nano particle to the biofilm resulted in an increasing in the swelling and biodegradation rate and with addition of 0.05 g of nano clay particle a significant decrease in the rate of degradation and swelling of the biofilm was archived. The drug release test results also showed that, no sever release by soya protein /chitosan/clay nano composite biofilm containing valsartan as well as the drug release indicated a uniform release of nano composite biofilms with 0% and 0.05% of nano clay particles. Then, MTT assay was evaluated, which showed no cytotoxicity results in any of the nano biofilms. Therefore, nano composite biofilms with 0% and 0.05% of nano clay may be a more suitable option for valsartan release through the nano composite bio film for lowering the blood pressure.
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