تاثیر یک دوره تمرین هوازی به همراه مصرف مکمل ویتامین C بر گیرنده لپتین و شاخص های استرس اکسیداتیو در بافت قلب موشهای ماده صحرایی مبتلا به آلزایمر
محورهای موضوعی : فیزیولوژی تجربی و آسیب شناسی
اسیه سید
1
(گروه فیزیولوژی ورزشی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران)
مرضیه فلاحیان
2
(گروه فیزیولوژی ورزشی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران.)
فروغ تجلی
3
(گروه فیزیولوژی ورزشی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران.)
سیده ام البنین قاسمیان
4
(گروه دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران * .)
کلید واژه: آلزایمر, آنزیم‌های ضد اکسایشی, استرس اکسیداتیو, ورزش هوازی, ویتامین C,
چکیده مقاله :
زمینه و هدف: آنزیم‌های ضد اکسایشی اولین خط دفاعی در برابر حمله‌ی انواع رادیکال‌های فعال اکسیژن می‌باشد. آنتی‌اکسیدان‌ها از طریق واکنش با رادیکال‌های آزاد و گونه‌های فعال باعث کاهش یا جلوگیری از استرس اکسیداتیو می‌شوند. مطالعه حاضر با هدف تاثیر یک دوره تمرین هوازی به همراه مصرف مکمل ویتامین C بر گیرنده لپتین، وزن چربی احشایی، BMI و آنزیم‌های ضد اکسایشی در بافت مغز موشهای صحرایی مبتلا به آلزایمر، صورت گرفت. مواد و روش ها: در این مطالعه تجربی، 45 سر موش صحرایی سالمند ماده به طور تصادفی به شش گروه کنترل مبتلا به آلزایمر، مکمل ویتامین C، تمرین هوازی، تمرین هوازی + ویتامین C و کنترل سالم، تقسیم شدند. شاخص‌های لپتین، وزن چربی احشایی و BMI پس از اتمام مداخله و شاخص‌های MDA، CAT و SOD پس از استخراج بافت مغز اندازه‌گیری شدند. نتایج: در گروه¬های مداخله مقادیر گیرنده لپتین به طور معنی¬داری بالاتر (001/0=P)، وزن چربی احشایی و BMI کمتر از گروه کنترل سالم بود (001/0=P). پس از هشت هفته تمرین هوازی و مصرف مکمل ویتامین C، مقادیر MDA به میزان معنی‌داری در گروه تمرین+مکمل کاهش پیدا کرد و مقادیر CAT و SOD افزایش پیدا کرد (05/0>P). نتیجه گیری: به نظر می‌رسد تمرین هوازی همراه با مکمل ویتامین C موجب افزایش بیان گیرنده لپتین، کاهش وزن چربی احشایی و BMI در موش های صحرایی مبتلا به بیماری آلزایمر می گردد و همچنین مقادیر MDA را کاهش و مقادیر CAT و SOD را افزایش می دهد.
Background & Aim: Antioxidant enzymes serve as the primary defense against the onslaught of various reactive oxygen radicals. Antioxidants mitigate or prevent oxidative stress by interacting with free radicals and active species. The present study aimed to determine the effect of a course of aerobic exercise comined with vitamin C supplementation on leptin receptor, visceral fat weight, body mass index (BMI), and antioxidant enzymes in the brain tissue of rats with Alzheimer's. Materials & Methods: In this experimental study, 45 elderly female rats were randomly assigned to six groups, including controls with Alzheimer's disease, vitamin C supplementation, aerobic exercise, aerobic exercise + vitamin C, and healthy controls. Leptin, visceral fat weight, and BMI after the intervention, as well as malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) indices, were measured after heart tissue extraction. Results: In the intervention groups, leptin receptor values were significantly higher (P=0.001), while visceral fat weight and BMI were lower than in the healthy control group (P=0.001). After eight weeks of aerobic exercise and vitamin C supplementation, MDA levels decreased significantly in the exercise+supplement group (P<0.05) and values of CAT and SOD were significantly increased compared to other groups (P<0.05). Conclusion: It seems that aerobic exercise combined with vitamin C supplements increases leptin receptor expression and decreases visceral fat weight and BMI in rats with Alzheimer's disease. Moreover, it decreases MDA levels and increases CAT and SOD levels.
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