Effect of a course of aerobic exercise combined with vitamin C supplementation on leptin receptor and oxidative stress in the heart tissue of female rats with Alzheimer's

Subject Areas : Experimental physiology and pathology

Asiye  Seyyed ¹ (Department of Sport physiology, Behbahan Branch, Islamic Azad University, Behbahan, Iran.)
Mazieh  Fallahiyan ² (Department of Sport physiology, Behbahan Branch, Islamic Azad University, Behbahan, Iran.)
Forough  Tajalli ³ (Department of Sport physiology, Behbahan Branch, Islamic Azad University, Behbahan, Iran.)
Seyedeh Ommolbanin  Ghasemian ⁴ (Department of Veterinary, Behbahan Branch, Islamic Azad University, Behbahan, Iran.)

Received: 2023-10-27 Accepted : 2024-02-21 Published : 2024-05-22

Keywords: Alzheimer, Antioxidant enzymes, Oxidative stress, Aerobic exercise, vitamin C,

Abstract :

Background & Aim: Antioxidant enzymes serve as the primary defense against the onslaught of various reactive oxygen radicals. Antioxidants mitigate or prevent oxidative stress by interacting with free radicals and active species. The present study aimed to determine the effect of a course of aerobic exercise comined with vitamin C supplementation on leptin receptor, visceral fat weight, body mass index (BMI), and antioxidant enzymes in the brain tissue of rats with Alzheimer's. Materials & Methods: In this experimental study, 45 elderly female rats were randomly assigned to six groups, including controls with Alzheimer's disease, vitamin C supplementation, aerobic exercise, aerobic exercise + vitamin C, and healthy controls. Leptin, visceral fat weight, and BMI after the intervention, as well as malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) indices, were measured after heart tissue extraction. Results: In the intervention groups, leptin receptor values were significantly higher (P=0.001), while visceral fat weight and BMI were lower than in the healthy control group (P=0.001). After eight weeks of aerobic exercise and vitamin C supplementation, MDA levels decreased significantly in the exercise+supplement group (P<0.05) and values of CAT and SOD were significantly increased compared to other groups (P<0.05). Conclusion: It seems that aerobic exercise combined with vitamin C supplements increases leptin receptor expression and decreases visceral fat weight and BMI in rats with Alzheimer's disease. Moreover, it decreases MDA levels and increases CAT and SOD levels.

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