Blood coagulation effect of combined extract of Thymus vulgaris and Medicago sativa
محورهای موضوعی : Medicinal and Herbal PlantsZahra Sadat Mashkani 1 , Jafar Vatandoost 2 , Toktam Hajjar 3 , Behnam Mahdavi 4
1 - Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
2 - Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
3 - Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
4 - Department of Chemistry, Hakim Sabzevari University, Iran
کلید واژه: Thymus vulgaris, Medicago sativa, Herbal medicine, Hemophilia,
چکیده مقاله :
Thymus vulgaris and Mediacgo sativa, are used as a traditional remedy in the treatment of bleeding disorders. Considering their probabilistic coagulation compounds, in an animal study, forty male mice were randomly divided into 5 groups (n = 8) as well as negative and positive control. Coagulation indices include bleeding time (BT), clotting time (CT), and the number of platelets (PLT) were examined on the 13th day of treatment. A significant reduction in the BT and CT tests, as well as a significant increase in PLT in the treated groups was observed. It is concluded that although the T. vulgaris and M. sativa extracts have a coagulation effect through primary homeostasis and a common pathway of secondary hemostasis, combined extracts are more effective than individual extracts. Moreover, phenolic and flavonoid compounds are the most affecting compounds that affect platelet number and aggregation.
Thymus vulgaris and Mediacgo sativa, are used as a traditional remedy in the treatment of bleeding disorders. Considering their probabilistic coagulation compounds, in an animal study, forty male mice were randomly divided into 5 groups (n = 8) as well as negative and positive control. Coagulation indices include bleeding time (BT), clotting time (CT), and the number of platelets (PLT) were examined on the 13th day of treatment. A significant reduction in the BT and CT tests, as well as a significant increase in PLT in the treated groups was observed. It is concluded that although the T. vulgaris and M. sativa extracts have a coagulation effect through primary homeostasis and a common pathway of secondary hemostasis, combined extracts are more effective than individual extracts. Moreover, phenolic and flavonoid compounds are the most affecting compounds that affect platelet number and aggregation.
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