Chemical composition, biological activities, and nutritional application of Asteraceae family herbs: A systematic review

محورهای موضوعی : Essential Oils: Classical and Advanced Techniques for Isolation and Biological Activities

Masoud Kazeminia ¹ ( Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran )
Ali Mehrabi ² ( Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran|Food Hygiene and Safety, School of Public Health, Qazvin University of Medical Sciences, Qazvin, Iran )
Razzagh Mahmoudi ³ ( Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran )

تاریخ دریافت : 1400/12/21 تاریخ پذیرش : 1401/04/30 تاریخ انتشار : 1401/06/10

کلید واژه: Essential oil, Medicinal herbs, Antioxidant, Asteraceae family, Antibacterial,

چکیده مقاله :

Medicinal herbs, including the Asteraceae family (AF), have different antimicrobial and therapeutic effects. Therefore, they can be used as health factors in the food and medicinal industries. In this systematic review, the essential information was collected from the relevant databases, e.g., PubMed, Sciencedirect, and Google Scholar based on medicinal herbs, AF, essential oil, antimicrobial, antioxidant, therapeutic effect, and Covid-19 keywords. AF can be used as safe preservatives and food additives with a specific amount of consumption in the food industry thanks to their good flavor, antioxidant and antimicrobial effect. Due to their therapeutic effects, they can improve the health role of food. AF herbs contain important bioactive compounds, but not all of them can be used as medicine and food supplements since yarrow, chamomile, and artichoke exhibit toxic effects in high dosage, therefore, the consumption of these herbs should be considered to not endanger the health of the consumer.

منابع و مأخذ:

Aali, E., Mahmoudi, R., Kazeminia, M., Hazrati, R., Azarpey, F., 2017. Essential oils as natural medicinal substances. Tehran Univ. Med. J. 75(7), 480-489. 
Abate, G., Zhang, L., Pucci, M., Morbini, G., Mac Sweeney, E., Maccarinelli, G., Ribaudo, G., Gianoncelli, A., Uberti, D., Memo, M., 2021. Phytochemical analysis and anti-inflammatory activity of different ethanolic phyto-extracts of Artemisia annua L. Biomol. 11(7), 975. doi.org/10.3390/biom11070975.
Abbasi, S., Farzanmehr, H., 2009. Optimization of extracting conditions of inulin from Iranian artichoke with/without ultrasound using response surface methodology. J. Sci. Technol. Agric. Nat. Resour. 13(47), 423-436. 
Abbaspour, J., Ehsanpour, A.A., Aghaei, M., Ghanadian, M., 2019. Sesquiterpene lactones from shoot culture of Artemisia aucheri with cytotoxicity against prostate and breast cancer cells. Res. Pharm. Sci. 14(4), 329-334. doi.org/10.4103/1735-5362.263557.
Abdanipour, A., Khatami, S., Tiraihi, T., Satari, M., 2015. Effect of hydro-ethanolic extract of Chamaemelum nobile on cell prolifration and apoptosis of rat hipocample neural stem cells in the oxitative stress condition. J. Gorgan Univ. Med. Sci. 16(4), 14-20. 
Abdel-Moneim, A., Ahmed, O.M., El-Twab, A., Sanaa, M., Zaky, M.Y., Bakry, L.N., 2021. Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in wistar rats. Environ. Sci. Pollut. Res. 28(32), 43515-43527. doi.org/10.1007/s11356-021-13391-x.
Abdolahzade, P., Shapouri, R., Nasiri, S.S., 2011. Antibacterial effects of Eucalyptus globulus extracts on Brucella melitensis M16 and Brucella abortus S99 in vitro and in vivo. J. Ardabil Univ. Med. Sci. 3(41), 218-227. 
Abdossalami, E., Neamati, A., Ardalan, T., 2020. Anti-angiogenesis properties of cerium oxide nanoparticles synthesized by green method from Persicaria bistorta plant. Qom Univ. Med. Sci. J. 14(2), 13-23. doi.org/10.29252/qums.14.2.13.
Abdullahzadeh, M., Naji, S., 2014. The effect of matricaria chamomilla on sleep quality of elderly people admitted to nursing homes. IJN 27(89), 69-79. doi.org/10.29252/ijn.27.89.69.
Aggarwal, K.K., Tripathi, A.K., Prajapati, V., Kumar, S., 2001. Toxicity of 1,8-cineole towards three species of stored product coleopterans. Int. J. Trop. Insect Sci. 21(2), 155-160. doi.org/10.1017/S1742758400020208.
Aghajanyan, A., Gabrielyan, L., Schubert, R., Trchounian, A., 2020. Silver ion bioreduction in nanoparticles using Artemisia annua L. extract: Characterization and application as antibacterial agents. AMB Express 10(1), 1-9. doi.org/10.1186/s13568-020-01002-w.
Ahameethunisa, A.R., Hopper, W., 2010. Antibacterial activity of Artemisia nilagirica leaf extracts against clinical and phytopathogenic bacteria. BMC Complementary Altern. Med. 10(1), 1-6. doi.org/10.1186/1472-6882-10-6.
Ahmadi Mahmoodabadi, N., Madani, H., Mahzooni, P., Vahdati, A., 2006. Preventive effect of hydroalcoholic Cynara Scolymus extract on appearance of type 1 diabetes mellitus in male rats. Iranian J. Diabetes Metab. 6(1), 37-44. 
Ahmadi, S.M., Niknia, S., Miri, M.A., Hadadi, T., 2020. Survey of antibacterial activity of alcoholic extracts of Aloe vera, German chamomile and Mentha piperita L. as natural preservative of pasteurized milk. New findings Vet. Microbiol. 3, 47-59. doi.org/10.22034/NFVM.2020.122714.
Ahmadvand, H., Amiri, H., Dalvand, H., Bagheri, S., 2013. Various antioxidant properties of essential oil and hydroalcoholic extract of Artemisa persica. J. Birjand Univ. Med. Sci. 20(4), 416-424. 
Ahmed, N., 2009. Alloxan diabetes-induced oxidative stress and impairment of oxidative defense system in rat brain: neuroprotective effects of cichorium intybus. Int. J. Diabetes Metab. 17, 105-109. doi.org/10.1159/000497681.
Al-Snafi Esmail, A., 2016. Medical importance of Cichorium intybus–a review. IOSR J. Pharm. 6(3), 41-56. 
Alhusaini, A., Fadda, L., Hasan, I.H., Ali, H.M., El Orabi, N.F., Badr, A.M., Zakaria, E., Alenazi, A.M., Mahmoud, A.M., 2019. Arctium lappa root extract prevents lead-induced liver injury by attenuating oxidative stress and inflammation, and activating akt/gsk-3β signaling. Antioxidants 8(12), 582. doi.org/10.3390/antiox8120582.
Ali, A.N.M., Saeed, N.A.H.A.A., Omear, H.A., 2021. The anticancer properties of Artemisia aucheri boiss extract on HT29 colon cancer cells. J. Gastrointest. Cancer 52(1), 113-119. doi.org/10.1007/s12029-019-00354-2.
Aljančić, I., Vajs, V., Menković, N., Karadžić, I., Juranić, N., Milosavljević, S., Macura, S., 1999. Flavones and sesquiterpene lactones from Achillea a trata subsp. M ultifida: antimicrobial activity. J. Nat. Prod. 62(6), 909-911. doi.org/10.1021/np980536m.
Andrade-Cetto, A., Wiedenfeld, H., 2001. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 78(2-3), 145-149. doi.org/10.1016/S0378-8741(01)00335-X.
Annunziata, G., Barrea, L., Ciampaglia, R., Cicala, C., Arnone, A., Savastano, S., Nabavi, S.M., Tenore, G.C., Novellino, E., 2019. Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: a critical review of in vitro and in vivo animal‐based studies. Phytother. Res. 33(9), 2213-2220. doi.org/10.1002/ptr.6416.
Appalasamy, S., Lo,K.Y., Ch'ng, S.J., Nornadia, K., Othman, A.S., Chan, L.K., 2014. Antimicrobial activity of artemisinin and precursor derived from in vitro plantlets of Artemisia annua L. Bio. Med. Res. Int. 2014(215872), 1-6. doi.org/10.1155/2014/215872.
Aqil, F., Ahmad, I., 2003. Broad-spectrum antibacterial and antifungal properties of certain traditionally used Indian medicinal plants. World J. Microbiol. Biotechnol. 19(6), 653-657. doi.org/10.1023/A:1025128104056.
Arbabian, S., Akhondzade, D.M., Akhavan, S.A., Chalabian, F., 2009. The study of antimicrobial effects of ethanolic, methanolic, acetonic and aqueous extracts of Cynara scolymus on some of bacteria and fungi. J. Microbiol. Knowl. 1(4), 21-28. 
Asgary, S., Naderi, G., Bashardoost, N., Etminan, Z., 2002. Antioxidant effect of the essential oil and extract of Matricaria chamomilla L. on isolated rat hepatocytes J. Med. Plants 1(1): 69-76. 
Asl, R.M.Z., Niakousari, M., Gahruie, H.H., Saharkhiz, M.J., Khaneghah, A.M., 2018. Study of two-stage ohmic hydro-extraction of essential oil from Artemisia aucheri Boiss.: antioxidant and antimicrobial characteristics. Food Res. Int. 107, 462-469. doi.org/10.1016/j.foodres.2018.02.059.
Atai, Z., Abdolahi, H., Naderi Poor, S., Mohamadi, S., 2006. An in vitro study of the effects of Yarrow, Chamomile and Rhubarb herbal extracts on Candida albicans and common oral bacteria. J. Islamic Dent. Assoc. Iran 18(3), 25-31. 
Azadbakht, M., Ziai, H., Abdollahi, F., Shabankhani, B., 2003. Effect of essential oils of Artemisia. Zataria and Myrtus on Trichomonas vaginalis. J. Med. Plants 2(8), 35-40. 
Azadbakht, M., Azadbakht, M., 2008. Five prevalent antiprotozoal herbal drugs. J. Mazandaran Univ. Med. Sci. 18(67), 1-15. 
Azizi Alidoust, F., Anvari, M., Ataei Jaliseh, S., 2020. Antimicrobial activity of aqueous and alcoholic extracts of chamomile, fleawort, aquatic pennyroyal and nettle plants on Klebsiella pneumoniae and comparing their effects with common antibiotics. Iranian J. Med. Microbiol. 14(4), 361-373. doi.org/10.30699/ijmm.14.4.361.
Azizi, M., Chizzola, R., Ghani, A., Oroojalian, F., 2010. Composition at different development stages of the essential oil of four Achillea species grown in Iran. Nat. Prod. Commun. 5(2), 1934578X1000500224. doi.org/10.1177/1934578X1000500224.
Azmodeh, F., Hajikhani, S., Alizadeh, S., 2016. Evaluation of the hydroalcoholic chamomile extract antifungal activity on Candida albicans-invitro study. J. Res. Dent. Sci. 13(4), 210-215. doi.org/10.18869/acadpub.jrds.13.4.210.
Badrabadi, A., Kachouei, M.A., Pirbalouti, A.G., Hamedi, B., 2015. Chemical compositions of essential oil of Artemisia aucheri collected from the Alpine regions in Kerman, Iran. J. Essent. Oil-Bear. Plants 18(3), 596-604. doi.org/10.1080/0972060X.2014.1001196.
Baggio, C.H., Freitas, C.S., Nhaducue, P.F., Rieck, L., Marques, M.C.A., 2002. Action of crude aqueous extract of leaves of Achillea millefolium L. (compositae) on gastrointestinal tract. Rev. Bras. Farmacogn. 12, 31-33. doi.org/10.1590/S0102-695X2002000300015.
Baghini, G.S., Sepahi, A.A., Tabatabaei, R.R., Tahvildari, K., 2018. The combined effects of ethanolic extract of Artemisia aucheri and Artemisia oliveriana on biofilm genes expression of methicillin resistant Staphylococcus aureus. Iranian J. Microbiol. 10(6), 417-423. PMCID: PMC6414741.
Bahmani, M., Shahinfard, N., Rafieian-Kopaei, M., Saki, K., Shahsavari, S., Taherikalani, M., Ghafourian, S., Baharvand-Ahmadi, B., 2015. Chicory: a review on ethnobotanical effects of Cichorium intybus L. J. Chem. Pharm. Sci. 8(4), 672-682.
Bas, Z., Turkoglu, V., Goz, Y., 2021. Investigation of inhibition effect of butanol and water extracts of Matricaria chamomilla L. on angiotensin‐converting enzyme purified from human plasma. Biotechnol. Appl. Biochem. 69(1), 237-280. doi.org/10.1002/bab.2106.
Ben Salem, M., Ben Abdallah Kolsi, R., Dhouibi, R., Ksouda, K., Charfi, S., Yaich, M., Hammami, S., Sahnoun, Z., Zeghal, K.M., Jamoussi, K., 2017. Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats. BMC Complementary Altern. Med. 17(1), 1-19. doi.org/10.1186/s12906-017-1835-8.
Ben Salem, M., Ksouda, K., Dhouibi, R., Charfi, S., Turki, M., Hammami, S., Ayedi, F., Sahnoun, Z., Zeghal, K. M., Affes, H., 2019. LC-MS/MS analysis and hepatoprotective activity of artichoke (Cynara Scolymus L.) leaves extract against high fat diet-induced obesity in rats. Bio. Med. Res. Int. 2019, 4851279. doi.org/10.1155/2019/4851279.
Bilia, A., de Malgalhaes, P.M., Bergonzi, M., Vincieri, F., 2006. Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar. Phytomedicine 13(7), 487-493. doi.org/10.1016/j.phymed.2006.01.008.
Bischoff, T.A., Kelley, C.J., Karchesy, Y., Laurantos, M., Nguyen-Dinh, P., Arefi, A.G., 2004. Antimalarial activity of lactucin and lactucopicrin: Sesquiterpene lactones isolated from Cichorium intybus L. J. Ethnopharmacol. 95(2-3), 455-457. doi.org/10.1016/j.jep.2004.06.031.
Bogdanović, M., Cankar, K., Dragićević, M., Bouwmeester, H., Beekwilder, J., Simonović, A., Todorović, S., 2020. Silencing of germacrene a synthase genes reduces guaianolide oxalate content in Cichorium intybus L. GM Crops Food 11(1), 54-66. doi.org/10.1080/21645698.2019.1681868.
Boghozian, A., Amjad, L., Shahanipour, K., 2014. Chemical constituents and identification of the essential oil of Artemisia aucheri Boiss. in Iran. Adv. Environ. Biol. 8(7), 2339-2343. 
Bohm, B. A., Stuessy, T. F., 2001. Flavonoids of the Sunflower Family (Asteraceae). Springer Science & Business Media.
Bozin, B., Mimica-Dukic, N., Bogavac, M., Suvajdzic, L., Simin, N., Samojlik, I., Couladis, M., 2008. Chemical composition, antioxidant and antibacterial properties of Achillea collina Becker ex Heimerl sl and A. pannonica Scheele essential oils. Molecules 13(9), 2058-2068. doi.org/10.3390/molecules13092058.
Burt, S., 2004. Essential oils: their antibacterial properties and potential applications in foods: A review. Int. J. Food Microbiol. 94(3), 223-253. doi.org/10.1016/j.ijfoodmicro.2004.03.022.
Caleja, C., Barros, L., Antonio, A.L., Ciric, A., Barreira, J.C., Sokovic, M., Oliveira, M.B.P., Santos-Buelga, C., Ferreira, I.C., 2015. Development of a functional dairy food: exploring bioactive and preservation effects of chamomile (Matricaria recutita L.). J. Funct. Foods 16, 114-124. doi.org/10.1016/j.jff.2015.04.033.
Carl, W., Emrich, L.S., 1991. Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients. J. Prosthet. Dent. 66(3), 361-369. doi.org/10.1016/0022-3913(91)90264-W.
Cavalcanti, A.M., Baggio, C.H., Freitas, C.S., Rieck, L., de Sousa, R.S., Da Silva-Santos, J.E., Mesia-Vela, S., Marques, M.C.A., 2006. Safety and antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in wistar rats. J. Ethnopharmacol. 107(2), 277-284. doi.org/10.1016/j.jep.2006.03.011.
Ćavar, S., Maksimović, M., Vidic, D., Parić, A., 2012. Chemical composition and antioxidant and antimicrobial activity of essential oil of Artemisia annua L. from Bosnia. Ind. Crops Prod. 37(1), 479-485. doi.org/10.1016/j.indcrop.2011.07.024.
Chan, Y.S., Cheng, L.N., Wu, J.H., Chan, E., Kwan, Y.W., Lee, S M.Y., Leung, G.P.H., Yu, P.H.F., Chan, S.W., 2011. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology 19(5), 245-254. doi.org/10.1007/s10787-010-0062-4.
Chen, U.C., Hsia, C.N., Yeh, M.S., Chandra Agrawal, D., Tsay, H.S., 2006. In vitro micropropagation and ex vitro acclimation of Bupleurum kaoi-an endangered medicinal plant native to Taiwan. In Vitro Cell. Dev. Biol. Plant 42(2), 128-133. doi.org/10.1079/IVP2005744.
Choi, C.W., Kim, S.C., Hwang, S.S., Choi, B.K., Ahn, H.J., Lee, M.Y., Park, S.H., Kim, S.K., 2002. Antioxidant activity and free radical scavenging capacity between Korean medicinal plants and flavonoids by assay-guided comparison. Plant Sci. 163(6), 1161-1168. doi.org/10.1016/S0168-9452(02)00332-1.
Choi, E., Park, H., Lee, J., Kim, G., 2013. Anticancer, antiobesity, and anti-inflammatory activity of Artemisia species in vitro. J. Tradit. Chin. Med. 33(1), 92-97. doi.org/10.1016/S0254-6272(13)60107-7.
Coruh, N., Celep, A.S., Özgökçe, F., İşcan, M., 2007. Antioxidant capacities of Gundelia tournefortii L. extracts and inhibition on glutathione-S-transferase activity. Food Chem. 100(3), 1249-1253. doi.org/10.1016/j.foodchem.2005.12.008.
Darnahal, E., Jamshidi, M., Jafarlou, M., Hasheminia, S., 2020. Insecticidal and repellent effects of essential oils from different parts of Achillea millefolium against adult of Oryzaephilus surinamensis L. (Coleoptera, Silvanidae). Applied Plant Prot. in Press. 
Datta, B.K., Mukhlesur Rahman, M., Gray, A.I., Nahar, L., Hossein, S.A., Auzi, A.A., Sarker, S. D., 2007. Polygosumic acid, a new cadinane sesquiterpene from Polygonum viscosum, inhibits the growth of drug-resistant Escherichia coli and Staphylococcus aureus (MRSA) in vitro. J. Nat. Med. 61(4), 391-396. doi.org/10.1007/s11418-007-0165-4.
de Moreno de LeBlanc, A., Del Carmen, S., Zurita-Turk, M., Santos Rocha, C., Van De Guchte, M., Azevedo, V., Miyoshi, A., LeBlanc, J.G., 2011. Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases. Int. Scholarly Res. Not. 2011, 1-11. doi.org/10.5402/2011/892971.
de Souza, A.R.C., Stefanov, S., Bombardelli, M.C., Corazza, M.L., Stateva, R.P., 2019. Assessment of composition and biological activity of Arctium lappa leaves extracts obtained with pressurized liquid and supercritical CO2 extraction. J. Supercrit. Fluids 152, 104573. doi.org/10.1016/j.supflu.2019.104573.
Dehghani Bidgoli, R., 2021. Chemical composition of essential oil and antifungal activity of Artemisia persica Boiss. from Iran. J. Food Sci. Technol. 58(4), 1313-1318. doi.org/10.1007/s13197-020-04640-x.
Demir, T., Ağaoğlu, S., 2021. Antioxidant, antimicrobial and metmyoglobin reducing activity of artichoke (Cynara scolymus) powder extract-added minced meat during frozen storage. Molecules 26(18), 5494. doi.org/10.3390/molecules26185494.
Demiray, S., Pintado, M., Castro, P., Technology, 2009. Evaluation of phenolic profiles and antioxidant activities of Turkish medicinal plants: Tilia argentea, Crataegi folium leaves and Polygonum bistorta roots. In. J. Pharmacol. Pharm. Sci. 54, 312-317. 
Dias, M.I., Barros, L., Dueñas, M., Pereira, E., Carvalho, A.M., Alves, R.C., Oliveira, M.B.P., Santos-Buelga, C., Ferreira, I.C., 2013. Chemical composition of wild and commercial Achillea millefolium L. and bioactivity of the methanolic extract, infusion and decoction. Food Chem. 141(4), 4152-4160. doi.org/10.1016/j.foodchem.2013.07.018.
Didier, F., Catherine, F., Odile, T., Jean-Louis, L., 2011. Caffeoyl derivatives: major antioxidant compounds of some wild herbs of the Asteraceae family. Food Nutr. Sci. 2, 181-192. doi.org/10.4236/fns.2011.230025.
Donohoe, D.R., Garge, N., Zhang, X., Sun, W., O'Connell, T.M., Bunger, M.K., Bultman, S.J., 2011. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab. 13(5), 517-526. doi.org/10.1016/j.cmet.2011.02.018.
Ebrahimi, M., Daryabeigi, R., Shahtalebi, M.A., Abedini, F., 2020. Wound dressing of second degree burn by chamomile cream and silver sulfadiazine cream; the effects on wound healing duration; a triple blind RCT. J. Med. Plants 19(75), 305-311. doi.org/10.29252/jmp.19.75.305.
Eftekhar-Sadat, B., Maghsumi-Noroozabad, L., Alipour, B., Abed, R., Asghari-Jafarabadi, M., 2016. Effect of Arctium lappa linne root (Burdock) tea consumption on lipid profile and blood pressure in patient with knee osteoarthritis. Razi J. Med. Sci. 22(140), 79-91. 
Ehsani, J., Mohsenzadeh, M., Khomeiri, M., Ghasemnezhad, A., 2018. Chemical characteristics, and effect of inulin extracted from artichoke (Cynara scolymus L.) root on biochemical properties of synbiotic yogurt at the end of fermentation. Iran. J. Chem. Chem. Eng. 37(2), 219-230. doi.org/1021-9986/2018/2/219-230.
EL-Hefny, M., Abo Elgat, W.A., Al-Huqail, A.A., Ali, H.M., 2019. Essential and recovery oils from Matricaria chamomilla flowers as environmentally friendly fungicides against four fungi isolated from cultural heritage objects. Processes 7(11), 1-12. doi.org/10.3390/pr7110809.
El-Massry, K.F., El-Ghorab, A.H., Farouk, A., 2002. Antioxidant activity and volatile components of Egyptian Artemisia judaica L. Food Chem. 79(3), 331-336. doi.org/10.1016/S0308-8146(02)00164-4.
El-Tantawy, W.H., 2015. Biochemical effects, hypolipidemic and anti-inflammatory activities of Artemisia vulgaris extract in hypercholesterolemic rats. J. Clin. Biochem., 33-38. doi.org/10.3164/jcbn.14-141.
Elmieh, A., Rafizadeh, B., Khanbabakhani, H., 2019. Effect of aerobic interval training and consumption of chicory extract on levels of liver enzymes in obese boys with non-alcoholic fatty liver. J. Appl. Exercise Physiol. 15(30), 103-114. doi.org/10.22080/JAEP.2019.15128.1822.
Englisch, W., Beckers, C., Unkauf, M., Ruepp, M., Zinserling, V., 2000. Efficacy of artichoke dry extract in patients with hyperlipoproteinemia. Fortschr. Arzneimittelforsch. 50(03), 260-265. doi.org/10.1055/s-0031-1300196.
Erdogan, O., Abbak, M., Demirbolat, G.M., Birtekocak, F., Aksel, M., Pasa, S., Cevik, O., 2019. Green synthesis of silver nanoparticles via Cynara scolymus leaf extracts: The characterization, anticancer potential with photodynamic therapy in MCF7 cells. PloS one 14(6), e0216496. doi.org/10.1371/journal.pone.0216496.
Ergezer, H., Kaya, H.İ., Şimşek, Ö., 2018. Antioxidant and antimicrobial potential of artichoke (Cynara scolymus L.) extract in beef patties. Czech J. Food Sci. 36(2), 154-162. doi.org/10.17221/179/2017-CJFS.
Eruygur, N., Koçyiğit, U., Taslimi, P., Ataş, M., Tekin, M., Gülçin, İ., 2019. Screening the in vitro antioxidant, antimicrobial, anticholinesterase, antidiabetic activities of endemic Achillea cucullata (Asteraceae) ethanol extract. S. Afr. J. Bot. 120, 141-145. doi.org/10.1016/j.sajb.2018.04.001.
Farhadi, N., Babaei, K., Farsaraei, S., Moghaddam, M., Pirbalouti, A.G., 2020. Changes in essential oil compositions, total phenol, flavonoids and antioxidant capacity of Achillea millefolium at different growth stages. Ind. Crops Prod. 152, 112570. doi.org/10.1016/j.indcrop.2020.112570.
Farhan, M.M., Hassawi, D.S., Ibraheem, N.K., 2018. Polyphenols compounds investigation of leaves and callus artichokes (Cynara scolymus). Plant Arch. 18(2), 2629-2635. 
Fathi, E., Majdi, M., Dastan, D., Maroufi, A., 2019. The spatio-temporal expression of some genes involved in the biosynthetic pathways of terpenes/phenylpropanoids in yarrow (Achillea millefolium). Plant Physiol. Biochem. 142, 43-52. doi.org/10.1016/j.plaphy.2019.06.036.
Feng, X., Cao, S., Qiu, F., Zhang, B., 2020. Traditional application and modern pharmacological research of Artemisia annua L. Pharmacol. Ther. 216, 107650. doi.org/10.1016/j.pharmthera.2020.107650.
Ferracane, R., Graziani, G., Gallo, M., Fogliano, V., Ritieni, A., 2010. Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves. J. Pharm. Biomed. Anal. 51(2), 399-404. doi.org/10.1016/j.jpba.2009.03.018.
Firouzbakhsh, F., Afsarian, M., Hooshangi, S., Badali, H., 2014. Evaluation of in vitro antifungal activity of Foeniculum, Achillea, Satureja, Cinnamomum and Artemisia against Saprolegnia parasitica. Arak Med. Univ. J. 17(5), 60-69. 
Frutos, M., Guilabert-Antón, L., Tomás-Bellido, A., Hernández-Herrero, J., 2008. Effect of artichoke (Cynara scolymus L.) fiber on textural and sensory qualities of wheat bread. Food Sci. Technol. Int. 14(5_suppl), 49-55. doi.org/10.1177/1082013208094582.
Frutos, M.J., Ruiz-Cano, D., Valero-Cases, E., Zamora, S., Pérez-Llamas, F., 2019. Artichoke (Cynara scolymus L.). Nonvitamin and Nonmineral Nutritional Supplements, Elsevier, pp. 135-138. doi.org/10.1016/B978-0-12-812491-8.00018-7.
Fu, C., Yu, P., Wang, M., Qiu, F., 2020. Phytochemical analysis and geographic assessment of flavonoids, coumarins and sesquiterpenes in Artemisia annua L. based on HPLC-DAD quantification and LC-ESI-QTOF-MS/MS confirmation. Food Chem. 312, 126070. doi.org/10.1016/j.foodchem.2019.126070.
Gao, Q., Yang, M., Zuo, Z., 2018. Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L. Acta Pharmacol. Sin. 39(5), 787-801. doi.org/10.1038/aps.2018.32.
Garcia-Oliveira, P., Barral, M., Carpena, M., Gullón, P., Fraga-Corral, M., Otero, P., Prieto, M.A., Simal-Gandara, J., 2021. Traditional plants from Asteraceae family as potential candidates for functional food industry. Food Funct. 12(7), 2850-2873. doi.org/10.1039/D0FO03433A.
Gebhardt, R., 1997. Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol. Appl. Pharmacol. 144(2), 279-286. doi.org/10.1006/taap.1997.8130.
Ghaderi, S., Sarailoo, M.H., Ghanbari, V., 2012. Investigation of the components and antibacterial effects of three plant's essential oil Coriandrum sativum, Achilleh millefolium, Anethum graveolens in vitro. J. Shahrekord Univ. Med. Sci. 14(5), 74-82. 
Ghaffarifar, F., KarimiPourSaryazdi, A., Ghaffari, A.D., Tavakoli, P., Barati, M., Rasekhi, A., KarimiPourSaryazdi, Y., Siahkohy, B., 2020. Anti-toxoplasma effects of Artemisia aucheri extract in vitro. Paramedical Sci. Military Health 15(1), 26-34. 
Ghanavati, M., Houshmand, S., Zainali, H., Abrahimpour, F., 2010. Chemical composition of the essential oils of Matricaria recutita L. belonging to central and south parts of Iran. J. Med. Plants 9(34), 102-108.
Gholizadeh ghara gheshlagh, A., Razavi Rohani, S.M., Mahmoudi, R., Kaboudari, A., Kazeminia, M., 2018. Antimicrobial effects of some herbal plants and spices on Staphylococcus epidermidis and Pseudomonas aeruginosa. Int. J. Food Nutr. Saf 9(1), 40-48. 
Ghelich, T., Hashemi Karouei, M., Gholampor Azizi, I., 2014. Antibacterial effect of methanolic extraction of Polygonum Bistorta on some bacteria. N. Z. J. Med. Lab. Technol. 8(2), 41-47. 
Gholamrezaie, S.L., Mohammadi, M., Jalali, S.J., Abolghasemi, S., Roostaei, A.M., 2013. Extract and leaf powder effect of Artemisia annua on performance, cellular and humoral immunity in broilers. Iranian J. Vet. Res. Shiraz Univ. 14(1), 15-20. doi.org/10.22099/IJVR.2013.1384.
Grieve, M., Herbal, A. M., 1984. Penguin Books. New York.
Gürbüz, İ., Üstün, O., Yeşilada, E., Sezik, E., Akyürek, N., 2002. In vivo gastroprotective effects of five Turkish folk remedies against ethanol-induced lesions. J. Ethnopharmacol. 83(3), 241-244. doi.org/10.1016/S0378-8741(02)00248-9.
Ha, M.S., Yook, J.S., Lee, M., Suwabe, K., Jeong, W.M., Kwak, J.J., Soya, H., 2021. Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome. Sci. Rep. 11(1), 1-10. doi.org/10.1038/s41598-021-84301-x.
Habibi, R.M., Mohammadi, R.A., Delazar, A., Halabian, R., Soleimani, R.J., Mehdipour, A., Bagheri, M., Jahanian-Najafabadi, A., 2011. Effects of Polygonum aviculare herbal extract on proliferation and apoptotic gene expression of MCF-7. Daru, J. Fac. Pharm., Tehran Univ. Med. Sci. 19(5), 326. PMCID: PMC3304393.
Habibi, Z., Ghanian, S., Ghasemi, S., Yousefi, M., 2013. Chemical composition and antibacterial activity of the volatile oil from seeds of Artemisia annua L. from Iran. Nat. Prod. Res. 27(2), 198-200. doi.org/10.1080/14786419.2012.662652.
Han, Y.H., Mun, J.G., Jeon, H.D., Yoon, D.H., Choi, B.M., Kee, J.Y., Hong, S.H., 2020. The extract of Arctium lappa L. fruit (Arctii Fructus) improves cancer-induced cachexia by inhibiting weight loss of skeletal muscle and adipose tissue. Nutrients 12(10), 3195. doi.org/10.3390/nu12103195.
Haq, F.U., Roman, M., Ahmad, K., Rahman, S.U., Shah, S.M.A., Suleman, N., Ullah, S., Ahmad, I., Ullah, W., 2020. Artemisia annua: trials are needed for COVID‐19. Phytother. Res. 34(10), 2423-2424. doi.org/10.1002/ptr.6733.
Harborne, A., 1998. Phytochemical Methods a Guide to Modern Techniques of Plant Analysis. Springer Science & Business Media.
Hasan, M., Das, R., Rahman, M., Hossain, M., Rahman, M., 2008. Micropropagation from shoot tips and nodal segments of Cassia alata L. Intl. J. Bio. Res. 4(4), 70-74. 
Hashem-Sirjani, F.A., Behmanesh, B., Mazandarani, M., Rostami Charati, F., 2020. Ethnopharmacology, phytochemical and antioxidant investigation of some of traditional high consumption plants for treatment of diabetes in the rural mountainous rangelands of Chaharbagh. Eco-phytochemical J. Med. Plants 8(3), 81-102. 
Hashemi, A., Shapouri, R., Esrafili, M., 2019. Antimicrobial and healing effect Burdock and Nasturtium of nettle, extracts with silver sulfadiazine on burn infections of Staphylococcus aureus. J. Anim. Morphol. Physiol. Dev. 12(2), 63-72. 
Hausbn, B., Bheuer, J., Weglewski, J., Rucker, G., 1991. α‐Peroxyachifolid and other new sensitizing sesquiterpene lactones from yarrow (Achillea millefolium L., compositae). Contact Dermatitis 24(4), 274-280. doi.org/10.1111/j.1600-0536.1991.tb01722.x.
Hegazy, M.E.F., Abdel-Lateff, A., Gamal-Eldeen, A.M., Turky, F., Hirata, T., Pare, P.W., Karchesy, J., Kamel, M.S., Ahmed, A.A., 2008. Anti-inflammatory activity of new guaiane acid derivatives from Achillea coarctata. Nat. Prod. Commun. 3(6), 851-856. doi.org/10.1177/1934578X0800300604.
Heidarian, E., Soofiniya, Y., Hajihosseini, R., 2011. The effect of aerial part of Cynara scolymus extract on the hyperlipidemia, plasma antioxidant capacity, and superoxide dismutase activity in diabetic rats. J. Shahrekord Univ. Med. Sci. 13(5), 1-9. 
Heidarianpour, A., Mohammadi, F., Keshvari, M., Mirazi, N., 2021. Ameliorative effects of endurance training and Matricaria chamomilla flowers hydroethanolic extract on cognitive deficit in type 2 diabetes rats. Biomed. Pharmacother. 135, 111230. doi.org/10.1016/j.biopha.2021.111230.
Höld, K.M., Sirisoma, N.S., Ikeda, T., Narahashi, T., Casida, J.E., 2000. α-Thujone (the active component of absinthe): γ-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc. Natl. Acad. Sci. 97(8), 3826-3831. doi.org/10.1073/pnas.070042397.
Hosseinpour, M.H., Askarianzadeh, A., Moharramipour, S., Sandi, J.J., 2011. Insecticidal activity of essential oils isolated from Rue. Integrated Prot. of Stored Prod. 69, 271-275. 
Hueza, I.M., Gotardo, A.T., da Silva Mattos, M.I., Górniak, S.L., 2019. Immunomodulatory effect of Cynara scolymus (artichoke) in rats. Phytother. Res. 33(1), 167-173. doi.org/10.1002/ptr.6210.
Innocenti, M., Gallori, S., Giaccherini, C., Ieri, F., Vincieri, F.F., Mulinacci, N., 2005. Evaluation of the phenolic content in the aerial parts of different varieties of Cichorium intybus L. J. Agric. Food Chem. 53(16), 6497-6502. doi.org/10.1021/jf050541d.
Intisar, A., Zhang, L., Luo, H., Zhang, R., Wu, Z., Zhang, W., 2012. Difference in essential oil composition of rhizome of Polygonum bistorta L. from different Asian regions and evaluation of its antibacterial activity. J. Essent. Oil-Bear. Plants 15(6), 964-971. doi.org/10.1080/0972060X.2012.10662600.
Ionita, R., Postu, P.A., Mihasan, M., Gorgan, D.L., Hancianu, M., Cioanca, O., Hritcu, L., 2018. Ameliorative effects of Matricaria chamomilla L. hydroalcoholic extract on scopolamine-induced memory impairment in rats: A behavioral and molecular study. Phytomedicine 47, 113-120. doi.org/10.1016/j.phymed.2018.04.049.
Izadi, Z., Modares Sanavi, S.A. M., Orooshzadeh, A., Esna Ashari, M., Davoodi, P., 2013. Antimicrobial activity of chamomile (Matricaria chamomilla L.) and feverfew (Tanacetum parthenium L.). Armaghane-danesh. Yasuj Univ. Med. Sci. J. 18(1), 31-43. 
Jafari Dinani, N., Asgary, S., Madani, H., Naderi, G., Mahzoni, P., 2010. Hypocholesterolemic and antiatherosclerotic effect of Artemisia aucheri in hypercholesterolemic rabbits. Pak. J. Pharm. Sci. 23(3), 321-325. 
Jafarinia, M., Jafarinia, M., 2019. A review of medicinal properties of some Asteraceae family plants on immune system. Rep. Health Care 5(2), 1-7.
Jaiswal, R., Kiprotich, J., Kuhnert, N., 2011. Determination of the hydroxycinnamate profile of 12 members of the Asteraceae family. Phytochemistry 72(8), 781-790. doi.org/10.1016/j.phytochem.2011.02.027.
Jamshidzadeh, A., Fereidooni, F., Salehi, Z., Niknahad, H., 2005. Hepatoprotective activity of Gundelia tourenfortii. J. Ethnopharmacol. 101(1-3), 233-237. doi.org/10.1016/j.jep.2005.04.013.
Jamshidzadeh, A., Khoshnoud, M., Dehghani, Z., Niknahad, H., 2006. Hepatoprotective activity of Cichorium intybus L. leaves extract against carbon tetrachloride induced toxicity. Iranian J. Pharm. Res. 5(1), 41-46. doi.org/10.22037/IJPR.2010.65.
Juteau, F., Masotti, V., Bessière, J.M., Dherbomez, M., Viano, J., 2002. Antibacterial and antioxidant activities of Artemisia annua essential oil. Fitoterapia 73(6), 532-535. doi.org/10.1016/S0367-326X(02)00175-2.
Kalhor, M., Yousefloo, S., Kavehie, B., Mohammadi, F., Javadi, H., 2019. Effect of yarrow (Achillea millefolium L.) extract on premenstrual syndrome in female students living in dormitory of qazvin university of medical sciences. J. Med. Plants 18, 52-63. doi.org/10.29252/jmp.4.72.S12.52.
Karaalp, C., Yurtman, A.N., Karabay Yavasoglu, N.U., 2009. Evaluation of antimicrobial properties of Achillea L. flower head extracts. Pharm. Biol. 47(1), 86-91. doi.org/10.1080/13880200802448682.
Karimi, M.H., Ebrahimnezhad, S., Namayandeh, M., Amirghofran, Z., 2014. The effects of cichorium intybus extract on the maturation and activity of dendritic cells. Daru, J. Pharm. Sci. 22(1), 1-7. doi.org/10.1186/2008-2231-22-28.
Karimipour Saryazdi, A., Ghaffarifar, F., Dalimi, A., Dayer, M.S., 2020. In vitro and in vivo comparative effects of the spring and autumn-harvested Artemisia aucheri Bioss extracts on Leishmania major. J. Ethnopharmacol. 257, 112910. doi.org/10.1016/j.jep.2020.112910.
Kaur, N., Gupta, A.K., 2002. Applications of inulin and oligofructose in health and nutrition. J. Biosci. 27(7), 703-714. doi.org/10.1007/BF02708379.
Kazemi, M., Dakhili, M., Dadkhah, A., Yasrebifar, Z., Larijani, K., 2011. Composition, antimicrobial and antioxidant activities of the essential oil of Artemisia kermanensis Podl., an endemic species from Iran. J. Med. Plants Res. 5(18), 4481-4486. doi.org/10.5897/JMPR.9000401.
Kazeminia, M., Mahmoudi, R., Ghajarbeygi, P., 2017. A review on using essential oil of Labiatae species in food products. J. Inflammatory Dis. 21(1), 73-61. 
Kemper, K.J., 1999. Ginger (Zingiber officinale). Longwood Herbal Task Force 3, 1-18.
Khedmat, L., Mojtahedi, S. Y., Moienafshar, A., 2021. Recent clinical evidence in the herbal therapy of neonatal jaundice in Iran: a review. J. Herb. Med. 29, 100457. doi.org/10.1016/j.hermed.2021.100457.
Khosravi, F., Moshtaghian, J., Zarkesh, S., 2021. The effect of ethanolic extract of Achillea wilhelmsii on the survival of three cancer cell lines in vitro culture. J. Cell Tissue Res. 11(4), 302-311. doi.org/10.52547/JCT.11.4.302.
Khushtar, M., Ahmad, A., Rahman, M.A., 2018. Gastroprotective effect of hydro-alcoholic extract of Polygonum bistorta Lin root in indomethacin-induced gastric ulcers in sprague dawley rats. Indian J. Pharm. Educ. Res. 52, 618-625. doi.org/10.5530/ijper.52.4.72.
Kim, B. H., Hong, S. S., Kwon, S. W., Lee, H. Y., Sung, H., Lee, I.-J., Hwang, B. Y., Song, S., Lee, C.-K., Chung, D., 2008. Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of nuclear factor-κB in macrophages. J. Pharmacol. Exp. Ther. 327(2), 393-401. doi.org/10.1124/jpet.108.140145.
Kim, Y.-D., Heo, I., Shin, B.-C., Crawford, C., Kang, H.-W., Lim, J.-H., 2013. Acupuncture for posttraumatic stress disorder: a systematic review of randomized controlled trials and prospective clinical trials. J. Evidence-Based Complement. Altern. Med. 2013, 1-12. doi.org/10.1155/2013/615857.
Kirchhoff, R., Beckers, C., Kirchhoff, G., Trinczek-Gärtner, H., Petrowicz, O., Reimann, H., 1994. Increase in choleresis by means of artichoke extract. Phytomedicine 1(2), 107-115. doi.org/10.1016/S0944-7113(11)80027-9.
Kiumarsi, A., Abomahboub, R., Rashedi, S.M., Parvinzadeh, M., 2009. Achillea millefolium, a new source of natural dye for wool dyeing. Prog. Color Colorants Coat. 2(2), 87-93. doi.org/10.30509/PCCC.2009.75758.
Kostić, A.Ž., Milinčić, D.D., Nedić, N., Gašić, U.M., Špirović Trifunović, B., Vojt, D., Tešić, Ž.L., Pešić, M.B., 2021. Phytochemical profile and antioxidant properties of bee-collected artichoke (Cynara scolymus) pollen. Antioxidants 10(7), 1091. doi.org/10.3390/antiox10071091.
Kupfersztain, C., Rotem, C., Fagot, R., Kaplan, B., 2003. The immediate effect of natural plant extract, Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. a preliminary report. Clin. Exp. Obstet. Gynecol. 30(4), 203-206. PMID: 14664413.
Lang, S.J., Schmiech, M., Hafner, S., Paetz, C., Steinborn, C., Huber, R., El Gaafary, M., Werner, K., Schmidt, C.Q., Syrovets, T., 2019. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients. Phytomedicine 62, 152962. doi.org/10.1016/j.phymed.2019.152962.
Law, S., Leung, A.W., Xu, C., 2020. Is the traditional Chinese herb “Artemisia annua” possible to fight against COVID-19? Integr. Med. Res. 9(3), 1-2. doi.org/10.1016/j.imr.2020.100474.
Li, H., Xia, N., Brausch, I., Yao, Y., Förstermann, U., 2004. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. J. Pharmacol. Exp. Ther. 310(3), 926-932. doi.org/10.1124/jpet.104.066639.
Li, K., Zhu, L., Li, H., Zhu, Y., Pan, C., Gao, X., Liu, W., 2019. Structural characterization and rheological properties of a pectin with anti-constipation activity from the roots of Arctium lappa L. Carbohydr. Polym. 215, 119-129. doi.org/10.1016/j.carbpol.2019.03.051.
Lin, H.W., Sun, M.X., Wang, Y.H., Yang, L.M., Yang, Y.R., Huang, N., Xuan, L.J., Xu, Y.M., Bai, D.L., Zheng, Y.T., 2010. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta Med. 76(09), 889-892. I doi.org/10.1055/s-0029-1240796.
Liu, Y.G., Hao, C., Shi, S., Dang, K., Huang, X., Zhao, Z., Shi, X., 2021. Transcriptome analysis of the immunomodulation by Arctium lappa L. polysaccharides in the Chinese mitten crab eriocheir sinensis against Aeromonas hydrophila. Aquaculture 534, 736255. doi.org/10.1016/j.aquaculture.2020.736255.
Lone, P.A., Bhardwaj, A.K., Shah, K.W., 2015. Prenanthes violaefolia Decne.(Asteraceae)-a new report from Kashmir Himalaya, India. Asian Pac. J. Trop. Biomed. 5(7), 552-554. doi.org/10.1016/j.apjtb.2014.06.006.
Madani, H., Asgari, S., Naderi, G., Talebolhoseini, M., 2006. Hepatoprotective effect of Chichorium Intybus L. on liver toxicity in rat. J. Med. Plants 5(17), 32-38. 
Maghsoudi, A., Saeidi, S., 2020. Evaluation of antimicrobial activity of ethanol extract of nine Zagros native medicinal plants against Salmonella Typhimurium. J. Vet. Res. 75(3), 380-389. doi.org/10.22059/JVR.2019.266899.2857.
Mahmoudi, R., Kazeminia, M., Kabodari, A., 2017. Review on composition and antimicrobial effects of Teucrium (Teucrium polium L.) grown in Iran and comparison with the around the world. J. Babol Univ. Med. Sci. 19(2), 54-64. doi.org/10.22088/jbums.19.2.54.
Mahmoudi, R., Kazeminia, M., Kaboudari, A., Pir-Mahalleh, S., Pakbin, B., 2017b. A review of the importance, detection and controlling of heavy metal in milk and dairy products. Malays. J. Sci. 36(1), 1-16. doi.org/10.22452/mjs.vol36no1.1.
Manoharan, K.P., Benny, T.K. H., Yang, D., 2005. Cycloartane type triterpenoids from the rhizomes of Polygonum bistorta. Phytochemistry 66(19), 2304-2308. doi.org/10.1016/j.phytochem.2005.07.008.
Martini, M.C., Zhang, T., Williams, J.T., Abramovitch, R.B., Weathers, P.J., Shell, S.S., 2020. Artemisia annua and Artemisia afra extracts exhibit strong bactericidal activity against Mycobacterium tuberculosis. J. Ethnopharmacol. 262, 113191. doi.org/10.1016/j.jep.2020.113191.
Masoudi, S., Rustaiyan, A., Vahedi, M., 2012. Volatile oil constituents of different parts of Artemisia chamaemelifolia and the composition and antibacterial activity of the aerial parts of A. turcomanica from Iran. Nat. Prod. Commun. 7(11), 1934578X1200701127. doi.org/10.1177/1934578X1200701127.
Massiha, A., Khoshkholgh-Pahlaviani, M.M., Issazadeh, K., Bidarigh, S., Zarrabi, S., 2013. Antibacterial activity of essential oils and plant extracts of Artemisia (Artemisia annua L.) in vitro. Zahedan J. Res. Med. Sci. 15(6), 14. 
Mazaraie, A., Fahmideh, L., 2020. Evaluation of phytochemical and antioxidant activity of three widely-used medicinal plant in natural habitats of Fars province. Eco-Phytochem. J. Med. Plants 8(1), 90-105. 
Mazid, M.A., Datta, B.K., Nahar, L., Bashar, S.K., Bachar, S.C., Sarker, S.D., 2011. Phytochemical studies on Polygonum barbatum (L.) Hara var. barbata (Polygonaceae). Rec. Nat. Prod. 5(2), 143-146. 
McKay, D.L., Blumberg, J.B., 2006. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother. Res. 20(7), 519-530. doi.org/10.1002/ptr.1900.
Mehani, M., Segni, L., Terzi, V., Morcia, C., Ghizzoni, R., Goudgil, B., Benchikh, S., 2018. Antifungal activity of Artemisia herba-alba on various Fusarium. Phytothérapie 16(2), 87-90. doi.org/10.1007/s10298-016-1071-2.
Mehrabi, A., Mahmoudi, R., Khedmati Morasa, H., Mosavi, S., Kazeminia, M., Attaran Rezaei, F., Shahsavari, S., Vahidi, R., 2021. Study of chemical composition, antibacterial and antioxidant activity of thyme leaves and stems essential oil. J. Med. Plants and By-product, In press. doi.org/10.22092/JMPB.2021.353440.1323.
Mejri, F., Baati, T., Martins, A., Selmi, S., Serralheiro, M.L., Falé, P.L., Rauter, A., Casabianca, H., Hosni, K., 2020. Phytochemical analysis and in vitro and in vivo evaluation of biological activities of artichoke (Cynara scolymus L.) floral stems: towards the valorization of food by-products. Food Chem. 333, 127506. doi.org/10.1016/j.foodchem.2020.127506.
Michalska, A., Wojdyło, A., Brzezowska, J., Majerska, J., Ciska, E., 2019. The influence of inulin on the retention of polyphenolic compounds during the drying of blackcurrant juice. Molecules 24(22), 4167. doi.org/10.3390/molecules24224167.
Milala, J., Grzelak, K., Król, B., Juskiewicz, J., Zdunczyk, Z., 2009. Composition and properties of Chicory extracts rich in fructans and polyphenols. Pol. J. Food Nutr. Sci. 59(1), 35-43. 
Milani, E., Kadkhodai, R., Golimovahhed, Q., Hosseini, F., 2012. Response surface methodology for optimization of ultrasound-assisted inulin extraction from Burdock Tuberous. J. Med. Plants 11(42), 68-76. 
Mir, T.A., Khare, R.K., Jan, M., 2021. A study on the use of medicinal plants for the treatment of diarrhoea and dysentery in Khag tehsil of Budgam District of Jammu and Kashmir, India. J. Med. Herbs Ethnomedicine 7, 6-10. doi.org/10.25081/jmhe.2021.v7.6896.
Mirazi, N., Bayat, S., Izadi, Z., 2019. The effect of chamomile extract (Matricaria chamomilla L.) and the concomitant use of aerobic exercise on serum lipids profile in type 1 diabetic male rats. Stud. Med. Sci. 30(9), 672-684. 
Mirbehbahani, F.S., Hejazi, F., Najmoddin, N., Asefnejad, A., 2020. Artemisia annua L. as a promising medicinal plant for powerful wound healing applications. Prog. Biomater. 9(3), 139-151. doi.org/10.1007/s40204-020-00138-z.
Modares, M., Besharat, S., Mahmoudi, M., 2012. Effect of ginger and chamomile capsules on nausea and vomiting in pregnancy. J. Gorgan Univ. Med. Sci. 14(1), 46-51. 
Modarres, M., Ali, M., Oshrieh, Z., Mehran, A., 2011. Comparison of the effect of mefenamic acid and Matricaria Camomilla capsules on primary dysmenorrhea. J. Babol Univ. Med. Sci. 13(3), 50-58. 
Moellering, J., Robert, C., 1998. Antibiotic resistance: lessons for the future. Clin. Infect. Dis. 27(Supplement_1), 135-140. 
Moghtader, M., Salari, H., Mozafari, H., Farhmand, A., 2018. Essential oil composition and antifungal activity of Artemisia Persica Boiss. in compare to synthetic borneol against the Aspergillus niger. Eco-phytochemical J. Med. Plants 6(3), 47-61. 
Mohammadhosseini, M., Frezza, C., Venditti, A., Mahdavi, B., 2021. An overview of the genus Aloysia Paláu (Verbenaceae): essential oil composition, ethnobotany and biological activities. Nat. Prod. Res., 1-17. doi.org/10.1080/14786419.2021.1907576.
Mohammadi Sichani, M., Amjad, L., Mohammadi-Kamalabadi, M., 2011. Antibacterial activity of methanol extract and essential oil of Achillea wilhelmsii against pathogenic bacteria. Zahedan J. Res. Med. Sci. 13(3). 
Mousavi, S., Kazemi, S., Mahroughi, M., Tanhaeian, A., 2021. Evaluation of antibacterial activity and toxicity of enterocin P peptide and two essential oils against animal pathogens. Vet. Res. Biol. Prod. 34(3), 48-54. doi.org/10.22092/VJ.2020.342383.1707.
Mozaffarian, V., 1996. A Dictionary of Iranian Plant Names. Vol. 396, Tehran, Farhang Moaser Press.
Mulabagal, V., Wang, H., Ngouajio, M., Nair, M.G., 2009. Characterization and quantification of health beneficial anthocyanins in leaf chicory (Cichorium intybus) varieties. Eur. Food Res. Technol. 230(1), 47-53. doi.org/10.1007/s00217-009-1144-7.
Munyangi, J., Cornet-Vernet, L., Idumbo, M., Lu, C., Lutgen, P., Perronne, C., Ngombe, N., Bianga, J., Mupenda, B., Lalukala, P., 2018. Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial. Phytomedicine 51, 1-17. doi.org/10.1016/j.phymed.2018.10.014.
Murakami, A., Takahashi, D., Kinoshita, T., Koshimizu, K., Kim, H.W., Yoshihiro, A., Nakamura, Y., Jiwajinda, S., Terao, J., Ohigashi, H., 2002. Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the α, β-unsaturated carbonyl group is a prerequisite. Carcinogenesis 23(5), 795-802. doi.org/10.1093/carcin/23.5.795.
Naeini, A., Khosravi, A., Tadjbakhsh, H., Ghazanfari, T., Yaraee, R., Shokri, H., 2010. Evaluation of the immunostimulatory activity of Ziziphora tenuior extracts. Comp. Clin. Pathol. 19(5), 459-463. doi.org/10.1007/s00580-009-0885-9.
Nair, M.S., Huang, Y., Fidock, D.A., Polyak, S.J., Wagoner, J., Towler, M., Weathers, P., 2021. Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants. J. Ethnopharmacol. 274, 114016. doi.org/10.1016/j.jep.2021.114016.
Nandagopal, S., Kumari, B.R., 2007. Phytochemical and antibacterial studies of Chicory (Cichorium intybus L.)-A multipurpose medicinal plant. Adv. Biol. Res. 1(1-2), 17-21. 
Narenjkar, J., Roghani, M., Sedaghat, R., Tahami, M., 2010. The effect of oral feeding of Cynara scolymus L. on thoracic aorta contractile response in diabetic rats. Daneshvar Med: Basic Clin. Res. J. 18(2), 43-52. 
Nariman, F., Eftekhar, F., Habibi, Z., Maserat, S., Malekzadeh, R., 2009. Antibacterial activity of twenty Iranian plant extracts against clinical isolates of Helicobacter pylori. Iran. J. Basic Med. Sci. 12(2), 105-111. doi.org/10.22038/IJBMS.2009.5151.
Nasirpour, M., Yavarmanesh, M., Mohhamadi Sani, A., Mohamdzade Moghadam, M., 2014. Antibacterial effect of aqueous extract of Artemisia aucheri, Artemisia sieberi and Hyssopus officinalis L. on the food borne pathogenic bacteria. J. Food Sci. Technol. 12(46), 53-64. 
Nassiri-Semnani, S., Gholikhani, F., Rahnema, M., Shapouri, R., Alizadeh, H., Gassempour, H., 2016. Evaluation of the antibacterial effects of Arctium lappa extracts on Brucella melitensis 16M in the animal model and macrophage culture. J. Mil. Med. 18(1), 315-322. 
Nateghi, R., Samadi, F., Ganji, F., Zerehdaran, S., 2013. Hepatoprotective effects of Cynara scolymus L. extract on CCl4 induced liver injury in broiler chickens. Int. J. Agri. Sci. 3(9), 678-688. 
Negahban, M., Moharramipour, S., Sefidkon, F., 2007. Fumigant toxicity of essential oil from Artemisia sieberi Besser against three stored-product insects. J. Stored Prod. Res. 43(2), 123-128. doi.org/10.1016/j.jspr.2006.02.002.
Nejati, S., Babaei, K., Varaei, S., Hajiaghaee, R., Kazemnejad, A., 2019. Effect of Matricaria recutita ointment on coronary artery bypass graft (CABG) wound healing in diabetic patients at imam ali hospital in kermanshah. J. Med. Plants 18, 204-211. doi.org/10.29252/jmp.4.72.S12.204.
Nematollahi, F., Rustaiyan, A., Larijani, K., Nadimi, M., Masoudi, S., 2006. Essential oil composition of Artemisia biennisz Willd. and Pulicaria undulata (L.) CA Mey., two compositae herbs growing wild in Iran. J. Essent. Oil Res. 18(3), 339-341. doi.org/10.1080/10412905.2006.9699106.
Nikbakht, M., Sharifi, S., Emami, S., Khodaie, L., 2014. Chemical composition and antiprolifrative activity of Artemisia persica Boiss. and Artemisia turcomanica Gand. essential oils. Res. Pharm. Sci. 9(2), 155. PMCID: PMC4311293.
Nishimura, H., Satoh, A., 2006. Antimicrobial and nematicidal substances from the root of chicory (Cichorium intybus). Allelochemicals: Biological Control of Plant Pathogens and Diseases, Springer, pp. 177-180. doi.org/10.1007/1-4020-4447-X_9.
Nwafor, I.C., Shale, K., Achilonu, M.C., 2017. Chemical composition and nutritive benefits of chicory (Cichorium intybus) as an ideal complementary and/or alternative livestock feed supplement. Sci. World J. 2017, 1-11. doi.org/10.1155/2017/7343928.
Oftadeh, M., Sendi, J.J., Ebadollahi, A., 2020. Toxicity and deleterious effects of Artemisia annua essential oil extracts on mulberry pyralid (Glyphodes pyloalis). Pestic. Biochem. Physiol. 170, 104702. doi.org/10.1016/j.pestbp.2020.104702.
Ogwuru, N., Adamczeski, M., 2000. Bioactive natural products derived from Polygonum species of plants: Their structures and mechanisms of action. Studies in Natural products chemistry, Elsevier, pp. 607-642. doi.org/10.1016/S1572-5995(00)80036-8.
Özbay, H., Alim, A., 2009. Antimicrobial activity of some water plants from the northeastern Anatolian region of Turkey. Molecules 14(1), 321-328. doi.org/10.3390/molecules14010321.
Pardakhty, A., Mollaei Emamzadeh, M., Emami, S.A., Taleghani, A., Mohammadpour, F., Javadi, B., 2021. Formulation of a niosomal gel containing chamomile hydro alcoholic extract with analgesic effect by film hydration method. J. North Khorasan Univ. Med. Sci. 13(1), 53-63. doi.org/10.52547/nkums.13.1.53.
Park, E.H., Bae, W.Y., Eom, S.J., Kim, K.T., Paik, H.D., 2017. Improved antioxidative and cytotoxic activities of chamomile (Matricaria chamomilla) florets fermented by Lactobacillus plantarum KCCM 11613P. J. Zhejiang Univ Sci. B 18(2), 152-160. doi.org/10.1631/jzus.B1600063.
Pazoki, R., Raeeni, M.G. N., Ghaffarifar, F., Saryazdi, A.K., Bineshian, F., 2019. The effect of aqueous extract of Artemisia aucheri seed on acanthamoeba in vitro. J. Pharm. Res. Int. 31, 1-10. doi.org/10.9734/JPRI/2019/v31i630367.
Perazzo, F.F., Carvalho, J.C.T., Carvalho, J., Rehder, V., 2003. Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L. Pharmacol. Res. 48(5), 497-502. doi.org/10.1016/S1043-6618(03)00216-0.
Pereira, J.V., Bergamo, D.C. B., Pereira, J.O., França, S.d.C., Pietro, R.C.L.R., Silva-Sousa, Y.T.C., 2005. Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections. South Braz. Dent. J. 16, 192-196. doi.org/10.1590/S0103-64402005000300004.
Pesewu, G.A., Cutler, R.R., Humber, D.P., 2008. Antibacterial activity of plants used in traditional medicines of Ghana with particular reference to MRSA. J. Ethnopharmacol. 116(1), 102-111. doi.org/10.1016/j.jep.2007.11.005.
Petropoulos, S.A., Levizou, E., Ntatsi, G., Fernandes, Â., Petrotos, K., Akoumianakis, K., Barros, L., Ferreira, I.C., 2017. Salinity effect on nutritional value, chemical composition and bioactive compounds content of Cichorium spinosum L. Food Chem. 214, 129-136. doi.org/10.1016/j.foodchem.2016.07.080.
Petrovic, J., Stanojkovic, A., Comic, L., Curcic, S., 2004. Antibacterial activity of Cichorium intybus. Fitoterapia 75(7-8), 737-739. doi.org/10.1016/j.fitote.2004.05.001.
Piri, E., Mahmoodi Sourestani, M., Khaleghi, E., Mottaghipisheh, J., Zomborszki, Z.P., Hohmann, J., Csupor, D., 2019. Chemo-diversity and antiradical potential of twelve Matricaria chamomilla L. populations from Iran: proof of ecological effects. Molecules 24(7), 1315. doi.org/10.3390/molecules24071315.
Podlech, D., Huber-Morath, A., Iranshahr, M., Rechinger, K., 1986. Anthemideae, Akademische Druck and Verlagsanstalt. Graz. Austria.
Pourmahdirad, G., Kesmati, M., 2009. Comparison of anxiolytic effect of Matricaria recutita in male and female mice in the presence and absence of gonads. Zahedan J. Res. Med. Sci. 11(2), 19-29. 
Qodrat, M., Habibollahi, H., Safari Motlagh, M.R., 2021. Molecular study of icaD biofilm gene expression by extract of ginger and artichoke in Staphylococcus aureus. Cell. Mol. Res., In Press. 
Qureshi, M.N., Stecher, G., Bonn, G.K., 2019. Determination of total polyphenolic compounds and flavonoids in Matricaria chamomilla flowers. Pak. J. Pharm. Sci. 32(5), 2163-2165. 
Rahimi, M., Sanagoo, A., Fatah, Z.A.S., Bahnampour, N., Jouybari, L., 2018. Effect of chamomile tea on the severity of dyspnea and anxiety in patients with chronic heart failure: a clinical trial study. J. Gorgan Univ. Med. Sci. 20(1), 9-15. 
Rahnavardi, M., Heydarifard, S., Mohammadi, M., 2018. The effect of chamomile odor on anxiety and some consequences of delivery in primiparous women. J. Health Care 20(3), 235-243. doi.org/10.29252/jhc.20.3.235.
Rajapriya, M., Sharmili, S.A., Baskar, R., Balaji, R., Alharbi, N.S., Kadaikunnan, S., Khaled, J.M., Alanzi, K.F., Vaseeharan, B., 2020. Synthesis and characterization of zinc oxide nanoparticles using Cynara scolymus leaves: Enhanced hemolytic, antimicrobial, antiproliferative, and photocatalytic activity. J. Cluster Sci. 31(4), 791-801. doi.org/10.1007/s10876-019-01686-6.
Rajput, P., Agnihotri, P., 2020. An overview of the genus Anemone L. (Ranunculaceae) in India. Plant Sci. Today 7(2), 136-141. doi.org/10.14719/pst.2020.7.2.657.
Ramak, P., Sefidkon, F., 2008. Investigating the quality and quantity of essential oil of Artemisia persica Boiss. in field and provenance. Iranian J. Med. Aromat. Plant Res. 24(2), 189-197. 
Rashed, K.N., Butnariu, M., 2021. Antimicrobial and antioxidant effects of Cichorium intybus aerial parts and chemical profile. Egypt. J. Chem. 64(8), 4689-4696. doi.org/10.21608/ejchem.2021.83913.4112.
Rasooli, I., Rezaee, M.B., Moosavi, M.L., Jaimand, K., 2003. Microbial sensitivity to and chemical properties of the essential oil of Artemisia annua L. J. Essent. Oil Res. 15(1), 59-62. doi.org/10.1080/10412905.2003.9712268.
Rasouli, M., Mahmoudi, R., Kazeminia, M., 2017. A review on the effect of medicinal plant essences on the performance of probiotic Bacteria. J. Mazandaran Univ. Med. Sci. 26(144), 411-423. 
Rehuš, Ľ., Neugebauerová, J., 2011. The comparison of the content of essential oil and flavonoids in selected species of genus Achillea millefolium agg. cultivated in conventional and organic way. Acta Fytotech. Zootech. 14, 33-35. 
Rezatofighi, S., Ebrahimian, M., Lordifar, P., Mehravar, N., Seyednejad, S., 2014. Antiviral activity of Citrus limon, Matricaria recutita L., Allium ascalonicum L., and Rosa damascene against Newcastle disease virus. J. Vet. Microbiol. 10(1), 1-8. 
Romualdo, G.R., Silva, E.d.A., Da Silva, T.C., Aloia, T.P., Nogueira, M.S., De Castro, I.A., Vinken, M., Barbisan, L.F., Cogliati, B., 2020. Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide‐induced model of steatohepatitis‐associated hepatocarcinogenesis. Environ. Toxicol. 35(4), 518-527. doi.org/10.1002/tox.22887.
Rossoni, G., Grande, S., Galli, C., Visioli, F., 2005. Wild artichoke prevents the age-associated loss of vasomotor function. J. Agric. Food Chem. 53(26), 10291-10296. doi.org/10.1021/jf052499s.
Rostampour, M., Aghaei, I., Soltani, B., Khakpour, B., 2014. Effect of Matricaria chamomilla hydro-alcoholic extract on PTZ-induced seizure in male mice. J. Guilan Univ. Med. Sci. 23(89), 8-14. 
Ruiz‐Cano, D., Frutos, M.J., Hernández‐Herrero, J.A., Pérez‐Llamas, F., Zamora, S., 2015. Effect of chlorophyll removal and particle size upon the nutritional and technological properties of powdered by‐products from artichoke (Cynara scolymus L.) industrial canning. Int. J. Food Sci. Technol. 50(11), 2383-2390. doi.org/10.1111/ijfs.12904.
Sabzehkar, F., Mogharab, M., Sharifzadeh, G., Kiani, Z., 2021. Comparison of the effect of chamomile and chlorhexidine glucosan cleansing on dental plaque and mucosal lesions of ventilated patients in the intensive care unit. J. Birjand Univ. Med. Sci. 28(2), 106-119. doi.org/10.32592/JBirjandUnivMedSci.2021.28.2.101.
Saeedach, S., Mahta Mazaheri, N., Seyed Kazem, S., Safora, B., 2014. Evaluation of antibacterial effects of aqueous extracts of Achillea millefolium and Teucrium polium plants on ten human pathogenic bacteria. J. Sabzevar Univ. Med. Sci. 21(4), 596-603. 
Saeidnia, S., Gohari, A., Mokhber-Dezfuli, N., Kiuchi, F., 2011. A review on phytochemistry and medicinal properties of the genus Achillea. Daru, J. Fac. Pharm., Tehran Univ. Med. Sci. 19(3), 173-186. PMCID: PMC3232110.
Safaei, L., Zeinali, H., Afiuni, D., 2011. Study of genetic variation of agronomic characteristics in Foeniculum vulgare Mill. genotypes. Iranian J. Rangelands and Forests Plant Breeding Genetic Res. 1, 167-180. doi.org/10.22092/IJRFPBGR.2011.10076.
Saghafi, N., Rhkhshandeh, H., Pourmoghadam, N., Pourali, L., Ghazanfarpour, M., Behrooznia, A., Vafisani, F., 2018. Effectiveness of Matricaria chamomilla (chamomile) extract on pain control of cyclic mastalgia: A double-blind randomised controlled trial. J. Obstet. Gynaecol. 38(1), 81-84. doi.org/10.1080/01443615.2017.1322045.
Saharkhiz, M., Sattari, M., Goodarzi, G., Omidbaigi, R., 2008. Assessment of antibacterial properties of Tanacetum parthenium L. essential oil. Iranian J. Med. Aromat. Plant Res. 24(1), 47-55.
Sánchez-Mata, M., Cabrera Loera, R., Morales, P., Fernández-Ruiz, V., Cámara, M., Díez Marqués, C., Pardo-de-Santayana, M., Tardío, J., 2012. Wild vegetables of the Mediterranean area as valuable sources of bioactive compounds. Genet. Resour. Crop Evol. 59(3), 431-443. doi.org/10.1007/s10722-011-9693-6.
Satmbekova, D., Srivedavyasasri, R., Orazbekov, Y., Omarova, R., Datkhayev, U., Ross, S.A., 2018. Chemical and biological studies on Cichorium intybus L. Nat. Prod. Res. 32(11), 1343-1347. doi.org/10.1080/14786419.2017.1343319.
Schuina, G.L., Quelhas, J.O.F., Castilhos, M.B.M.d., Carvalho, G. B.M.d., Del Bianchi, V.L., 2019. Alternative production of craft lager beers using artichoke (Cynara scolymus L.) as a hops substitute. Food Sci. Technol. 40, 157-161. doi.org/10.1590/fst.35318.
Sen, R., Bandyopadhyay, S., Dutta, A., Mandal, G., Ganguly, S., Saha, P., Chatterjee, M., 2007. Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes. J. Med. Microbiol. 56(9), 1213-1218. doi.org/10.1099/jmm.0.47364-0.
Shabani, F., Zareian, M.A., 2020. Evaluation of the synergism of medicinal effects of chamomile and ginger on pain and symptoms of primary dysmenorrhea: a randomized controlled trial. Complementary Med. J. 9(4), 3852-3867. doi.org/10.32598/cmja.9.4.351.3.
Shah, P., Nishan, N., Patel, A., Bhat, C., Choudhary, S., Shah, R., 2018. Comparative evaluation of antimicrobial properties of chicory extract and chlorhexidine mouthwash against Streptococcus mutans and Lactobacillus acidophilus. Int. Dental Med. J. Adv. Res. 4, 1-4. 
Shahani, S., Zakeri, N., Hamzkanlu, N., Hosseinimehr, S.J., 2015. The protective effects of Cichorium intybus L. seed extract against cell toxicity induced by bleomycin on human non-malignant fibroblast and ovarian cancer cells. J. Mazandaran Univ. Med. Sci. 24(121), 39-47. 
Shahverdi, S.A., Zia, J.N., Ruhi, L., 2020. Evaluation of anti-inflammatory effect of chicory extract on inflammatory factors of interleukin 8 and TNFα in rats with polycystic ovary syndrome. J. Adv. Biomed. Sci. 10(2), 2387-2395. 
Shali, R., Neamati, A., Ardalan, P., 2019. Investigating the cytotoxic effect and antioxidant properties of green synthesized silver nanoparticles from the root of Persicaria Bistorta on human liver cancer cell line (Hep G2). J. Ilam Univ. Med. Sci. 26(6), 133-142. doi.org/10.29252/sjimu.26.6.133.
Shen, B.B., Yang, Y.P., Yasamin, S., Liang, N., Su, W., Chen, S.H., Wang, X.J., Wang, W., 2018. Analysis of the phytochemistry and bioactivity of the genus polygonum of polygonaceae. Digital Chin. Med. 1(1), 19-36. doi.org/10.1016/S2589-3777(19)30005-9.
Shen, Q., Zhang, L., Liao, Z., Wang, S., Yan, T., Shi, P., Liu, M., Fu, X., Pan, Q., Wang, Y., 2018. The genome of Artemisia annua provides insight into the evolution of Asteraceae family and Artemisinin biosynthesis. Mol. Plant 11(6), 776-788. doi.org/10.1016/j.molp.2018.03.015.
Shimoda, H., Ninomiya, K., Nishida, N., Yoshino, T., Morikawa, T., Matsuda, H., Yoshikawa, M., 2003. Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): Structure requirement and mode of action. Bioorg. Med. Chem. Lett. 13(2), 223-228. doi.org/10.1016/S0960-894X(02)00889-2.
Shwaikh, A.K., Hassan, A.J., Rashid, K.H., 2021. Synergistic immunosuppressive activity of chamomile flower (Matricaria Chamomilla L.) extracts and methotrexate in vivo. Ann. the Romanian Soc. Cell Biol. 25(6), 15386-15394. 
Siadat, S., Direkvand-Moghadam, F., 2018. Study of phytochemical characteristics Artemisia persica Boiss in Ilam Province. Future Nat. Prod. 4(3), 55-63. 
Skowrońska, W., Granica, S., Dziedzic, M., Kurkowiak, J., Ziaja, M., Bazylko, A., 2021. Arctium lappa and Arctium tomentosum, sources of Arctii radix: comparison of anti-lipoxygenase and antioxidant activity as well as the chemical composition of extracts from aerial parts and from roots. Plants 10(1), 1-19. doi.org/10.3390/plants10010078.
Slade, D., Galal, A.M., Gul, W., Radwan, M.M., Ahmed, S.A., Khan, S.I., Tekwani, B.L., Jacob, M.R., Ross, S.A., ElSohly, M.A., 2009. Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers. Bioorg. Med. Chem. 17(23), 7949-7957. doi.org/10.1016/j.bmc.2009.10.019.
Smolarz, H., Budzianowski, J., Bogucka‐Kocka, A., Kocki, J., Mendyk, E., 2008. Flavonoid glucuronides with anti‐leukaemic activity from Polygonum amphibium L. Phytochem. Anal. 19(6), 506-513. doi.org/10.1002/pca.1076.
Sofalian, O., Zare, N., Latifi, S., Hasanpour, K., Motalebinia, S., 2020. Evaluation of anticancer effect of Mentha longifolia and Artemisia persica hydro-alcoholic extracts against human gastric cancer cells (AGS). Genetic Eng. Biosaf. J. 9(1), 1-10. 
Soltani, L., Darbemamieh, M., 2020. Comparison of Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-veneris and Apricot kernel extracts effects on the proliferation and apoptosis of breast cancer cells. J. Cell Tissue Res. 11(1), 73-86. 
Soltani, M., Moghimian, M., Abtahi-Eivari, S.H., Shoorei, H., Khaki, A., Shokoohi, M., 2018. Protective effects of Matricaria chamomilla extract on torsion/detorsion-induced tissue damage and oxidative stress in adult rat testis. Int. J. Fertil. Steril. 12(3), 242-248. doi.org/10.22074/ijfs.2018.5324.
Son, J.H., Islam, M.A., Hong, J.H., Jeong, J.Y., Song, O.Y., Kim, H.E., Khan, N., Jamila, N., Kim, K.S., 2021. Extraction of volatile organic compounds from leaves of Ambrosia artemisiifolia L. and Artemisia annua L. by headspace-solid phase micro extraction and simultaneous distillation extraction and analysis by gas chromatography/mass spectrometry. Food Sci. Biotechnol. 30(3), 355-366. doi.org/10.1007/s10068-020-00875-8.
Sonker, N., Pandey, A.K., Singh, P., 2015. Efficiency of Artemisia nilagirica (Clarke) Pamp. essential oil as a mycotoxicant against postharvest mycobiota of table grapes. J. Sci. Food Agric. 95(9), 1932-1939. doi.org/10.1002/jsfa.6901.
Sotiropoulou, N.S., Megremi, S.F., Tarantilis, P., 2020. Evaluation of antioxidant activity, toxicity, and phenolic profile of aqueous extracts of chamomile (Matricaria chamomilla L.) and sage (Salvia officinalis L.) prepared at different temperatures. Appl. Sci. 10(7), 1-14. doi.org/10.3390/app10072270.
Sozangar, N., Jeddi, F., Reaghi, S., Khorrami, S., Arzemani, K., 2012. Abulkhalsa and yarrow plant effect on Leishmania major in vitro. J. North Khorasan Univ. Med. Sci. 4(3), 329-333. doi.org/10.29252/jnkums.4.3.329.
Srinivasan, D., Nathan, S., Suresh, T., Perumalsamy, P.L., 2001. Antimicrobial activity of certain Indian medicinal plants used in folkloric medicine. J. Ethnopharmacol. 74(3), 217-220. doi.org/10.1016/S0378-8741(00)00345-7.
Srivastava, J.K., Shankar, E., Gupta, S., 2010. Chamomile: A herbal medicine of the past with a bright future. Mol. Med. Rep. 3(6), 895-901. doi.org/10.3892/mmr.2010.377.
Stanojevic, L.P., Marjanovic-Balaban, Z.R., Kalaba, V.D., Stanojevic, J.S., Cvetkovic, D.J., 2016. Chemical composition, antioxidant and antimicrobial activity of chamomile flowers essential oil (Matricaria chamomilla L.). J. Essent. Oil-Bear. Plants 19(8), 2017-2028. doi.org/10.1080/0972060X.2016.1224689.
Street, R.A., Sidana, J., Prinsloo, G., 2013. Cichorium intybus: Traditional uses, phytochemistry, pharmacology, and toxicology. J. Evidence-Based Complementary Altern. Med. 2013, 1-13. doi.org/10.1155/2013/579319.
Subiza, J., Subiza, J., Alonso, M., Hinojosa, M., Garcia, R., Jerez, M., Subiza, E., 1990. Allergic conjunctivitis to chamomile tea. Ann. Allergy 65(2), 127-132. PMID: 2382873.
Sümer, E., Senturk, G.E., Demirel, Ö.U., Yesilada, E., 2020. Comparative biochemical and histopathological evaluations proved that receptacle is the most effective part of Cynara scolymus against liver and kidney damages. J. Ethnopharmacol. 249, 112458. doi.org/10.1016/j.jep.2019.112458.
Tadayoni, Z., Shafaroodi, H., Asgarpanah, J., 2018. Analgesic and anti-inflammatory activities of the essential oil from Artemisia aucheri Boiss. J. Essent. Oil-Bear. Plants 21(2), 440-448. doi.org/10.1080/0972060X.2017.1396929.
Taherkhani, M., 2017. Chemical constituents, total phenolic content, antimicrobial, antioxidant and radical scavenging properties, chelating ability, tyrosinase inhibition and in vitro cytotoxic effects of Artemisia aucheri herbs. Pharm. Chem. J. 50(11), 736-745. doi.org/10.1007/s11094-017-1523-5.
Talei, G.R., Meshkat, A.M., Delfan, B., 2004. Antibacterial activity of fruit, leaves extracts of Artemisia persica boiss, rhus coriaria, ephedra intermedia and daphne mucronata royle of lorestan. Yafteh 5(3), 19-23. 
Tayefeh, H.E., Sefidkon, F., Yousefi, M., Teimouri, M., 2012. Essential oil composition and antimicrobial activities of oil, alcoholic extract of Artemisia sieberi from Firoozkooh region. Iran. J. Biol. 25(3), 445-455. 
Thabet, A.A., Youssef, F.S., Korinek, M., Chang, F.R., Wu, Y.C., Chen, B.H., El-Shazly, M., Singab, A.N.B., Hwang, T.L., 2018. Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models. BMC Complementary Med. Ther. 18(1), 1-15. doi.org/10.1186/s12906-018-2359-6.
Tripathi, A., Prajapati, V., Aggarwal, K., Khanuja, S., Kumar, S., 2000. Repellency and toxicity of oil from Artemisia annua to certain stored-product beetles. J. Econ. Entomol. 93(1), 43-47. doi.org/10.1603/0022-0493-93.1.43.
Turkiewicz, I.P., Wojdyło, A., Tkacz, K., Nowicka, P., Hernández, F., 2019. Antidiabetic, anticholinesterase and antioxidant activity vs. terpenoids and phenolic compounds in selected new cultivars and hybrids of artichoke Cynara scolymus L. Molecules 24(7), 1-15. doi.org/10.3390/molecules24071222.
Van Ketel, W., 1987. Allergy to Matricaria chamomilla. Contact Derm. 16(1), 50-51. doi.org/10.1111/j.1600-0536.1987.tb02629.x.
Van Wyk, B.E., Wink, M., 2018. Medicinal Plants of the World. CABI.
Vasconcelos, A.A., Alves Filho, E.G., Rodrigues, T.H., Vieira, A.F., Innecco, R., Silva, G.S., Zocolo, G.J., 2020. Variability of the volatile organic compounds of Achillea millefolium L. according to the collection time, type of polyethylene packaging and storage period. J. Braz. Chem. Soc. 31, 1021-1029. doi.org/10.21577/0103-5053.20190268.
Verdian-rizi, M., 2009. Chemical composition and antimicrobial activity of the essential oil of Artemisia annua L. from Iran. Pharmacogn. Res. 1(1), 21-24. 
Vidic, D., Čopra-Janićijević, A., Miloš, M., Maksimović, M., 2018. Effects of different methods of isolation on volatile composition of Artemisia annua L. Int. J. Anal. Chem. 2018, 1-6. doi.org/10.1155/2018/9604183.
Vignesh, A., Pradeepa Veerakumari, K., Selvakumar, S., Rakkiyappan, R., Vasanth, K., 2021. Nutritional assessment, antioxidant, anti-inflammatory and antidiabetic potential of traditionally used wild plant, Berberis tinctoria Lesch. Trends Phytochem. Res. 5(2), 71-92. doi.org/10.30495/TPR.2021.1914719.1186.
Wagih Abd ElFattah, E., El, A., 2014. Antimicrobial activity of chamomile acetone extract against some experimentally-induced skin infections in mice. EJER 2, 58-70. 
Wang, Y., Tang, H., Nicholson, J.K., Hylands, P.J., Sampson, J., Holmes, E., 2005. A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion. J. Agric. Food Chem. 53(2), 191-196. doi.org/10.1021/jf0403282.
Watanabe, A., Sasaki, H., Miyakawa, H., Nakayama, Y., Lyu, Y., Shibata, S., 2020. Effect of dose and timing of burdock (Arctium lappa) root intake on intestinal microbiota of mice. Microorganisms 8(2), 1-19. doi.org/10.3390/microorganisms8020220.
Wu, X., Zhang, N., Kan, J., Tang, S., Sun, R., Wang, Z., Chen, M., Liu, J., Jin, C., 2021. Polyphenols from Arctium lappa L. ameliorate doxorubicin‐induced heart failure and improve gut microbiota composition in mice. J. Food Biochem. 46(3), 1-17. doi.org/10.1111/jfbc.13731.
Xia, J., Guo, Z., Fang, S., Gu, J., Liang, X., 2021. Effect of drying methods on volatile compounds of Burdock (Arctium lappa L.) root tea as revealed by gas chromatography mass spectrometry-based metabolomics. Foods 10(4), 868. doi.org/10.3390/foods10040868.
Xiang, L., Xing, D., Wang, W., Wang, R., Ding, Y., Du, L., 2005. Alkaloids from Portulaca oleracea L. Phytochemistry 66(21), 2595-2601. doi.org/10.1016/j.phytochem.2005.08.011.
Yan, L., Xiong, C., Xu, P., Zhu, J., Yang, Z., Ren, H., Luo, Q., 2019. Structural characterization and in vitro antitumor activity of a polysaccharide from Artemisia annua L.(Huang Huahao). Carbohydr. Polym. 213, 361-369. doi.org/10.1016/j.carbpol.2019.02.081.
Yang, W.S., Lee, S.R., Jeong, Y.J., Park, D.W., Cho, Y.M., Joo, H.M., Kim, I., Seu, Y.B., Sohn, E.H., Kang, S.C., 2016. Antiallergic activity of ethanol extracts of Arctium lappa L. undried roots and its active compound, oleamide, in regulating FcεRI-mediated and MAPK signaling in RBL-2H3 cells. J. Agric. Food Chem. 64(18), 3564-3573. doi.org/10.1021/acs.jafc.6b00425.
Yang, Y., Gao, H., Liu, W., Liu, X., Jiang, X., Li, X., Wu, Q., Xu, Z., Zhao, Q., 2021. Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy. Phytomedicine 85, 153526. doi.org/10.1016/j.phymed.2021.153526.
Yari, S., 2016. The effects of hydro-ethanolic extract of Arctium lappa leaves on wound healing. Appl. Biol. 29(1), 191-204. doi.org/10.22051/JAB.2016.2476.
Zafar, R., Ali, S.M., 1998. Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J. Ethnopharmacol. 63(3), 227-231. doi.org/10.1016/S0378-8741(98)00087-7.
Zahra, I., Majid, A., Mahmood, E.A., Poorandokht, D., 2013. Determining chemical composition and antimicrobial activity of feverfew [tanacetum parthenium L.] essential oil on some microbial strains. Zahedan J. Res. Med. Sci. 15(6), 8-13. 
Zakeri, S., Gorji, N., Moeini, R., 2019. Therapeutic application of Achillea millefolium L. in female reproductive diseases from the viewpoint of Persian medicine and current medicine. J. Med. Plants 18(72), 107-121. doi.org/10.29252/jmp.4.72.107.
Zaman, E.M., Tehranipour, M., Hassan, V.G., Nejad, S.A.K., Shiravi, A., 2019. Study of the gene expression changes TNF-Α, BCL2, IL-6, and IL-1β In male rats with nephrolithiasis treated the aqueous extract of Cichorium intybus L. flower. J. Anim. Morphol. Physiol. Dev. 12, 47-58. 
Zargari, A., 1991. Medicinal Plants Vol. 2, Tehran University.
Zeb, A., Haq, A., Murkovic, M., 2019. Effects of microwave cooking on carotenoids, phenolic compounds and antioxidant activity of Cichorium intybus L.(chicory) leaves. Eur. Food Res. Technol. 245(2), 365-374. doi.org/10.1007/s00217-018-3168-3.
Zhang, X., Zhang, N., Kan, J., Sun, R., Tang, S., Wang, Z., Chen, M., Liu, J., Jin, C., 2020a. Anti-inflammatory activity of alkali-soluble polysaccharides from Arctium lappa L. and its effect on gut microbiota of mice with inflammation. Int. J. Biol. Macromol. 154, 773-787. doi.org/10.1016/j.ijbiomac.2020.03.111.
Zhang, S.Q., Xu, H.B., Zhang, S.J., Li, X.Y., 2020b. Identification of the active compounds and significant pathways of Artemisia annua in the treatment of non-small cell lung carcinoma based on network pharmacology. Med. Sci. Monit. 26, e923624-923621. doi.org/10.12659/MSM.923624.
Zhang, B., Li, M., Qiao, Y., Gao, P., Li, L., Zheng, Z., 2020c. Potential use of low-field nuclear magnetic resonance to determine the drying characteristics and quality of Arctium lappa L. in hot-blast air. Lwt 132, 109829. doi.org/10.1016/j.lwt.2020.109829.
Zhang, Y.q., Wei, D., Zhao, Z.M., Jing, W., FAN, Y.h., 2008. Studies on acaricidal bioactivities of Artemisia annua L. extracts against Tetranychus cinnabarinus Bois.(Acari: Tetranychidae). Agric. Sci. China 7(5), 577-584. doi.org/10.1016/S1671-2927(08)60055-3.
Zhao, J., Evangelopoulos, D., Bhakta, S., Gray, A.I., Seidel, V., 2014. Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents. J. Ethnopharmacol. 155(1), 796-800. doi.org/10.1016/j.jep.2014.06.034.
Zhao, Y.f., Sun, P., Ma, Y., Wang, K., Chang, X.q., Bai, Y., Yang, L.x., Zhang, D., Yang, L., 2020. Chemical constituents of Matricaria chamomilla. Chem. Nat. Compd. 56(2), 364-365. doi.org/10.1007/s10600-020-03034-x.
Zhao, Y., Zhang, D., Liang, C., Yang, L., Sun, P., Ma, Y., Wang, K., Chang, X., Yang, L., 2018. Chemical constituents from Matricaria chamomilla L. J. Chin. Pharm. Sci. 27(5), 324. doi.org/10.5246/jcps.2018.05.033.
Zheng, G.Q., 1994. Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med. 60(01), 54-57. doi.org/10.1055/s-2006-959408.
Zhu, X., Zhang, H., Lo, R., 2004. Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities. J. Agric. Food Chem. 52(24), 7272-7278. doi.org/10.1021/jf0490192.
Ziai, S., Dastpak, A., Naghdi Badi, H., PoorHoseini, L., Hemati, A., 2005. Review on Cynara scolymus L. J. Med. Plants 4(13), 1-10.