Antihyperlipidemic activity of a unani formulation in high fat diet-induced obese murine model
محورهای موضوعی : Pharmacognosy
Md Rafiul Haque
1
(
Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, Hamdard Nager, New Delhi 62, India
)
Shahid Hussain Ansari
2
(
HIMT college of Pharmacy, Gr. Noida (U.P), India
)
کلید واژه: High fat diet, Unani formulation, Pancreatic lipase, Arq Zeera, body weight,
چکیده مقاله :
Arq zeera (AZ), a poly herbal unani formulation has been used traditionally as a remedy for reducing body fat and gastric disorder. The current study was designed to investigate the antihyperlipidemic activity of AZ against rat model of high fat diet (HFD) - induced obesity. AZ was prepared and administered orally 7.75 ml/kg/twice a day for 4 weeks to HFD- induced obese rat. Body weight and serum biomarkers were evaluated. Stability testing of AZ was also carried out. At the end of study, HFD significantly (p < 0.001) increased body weight, cholesterol, triglycerides, pancreatic lipase activity and malondialdehyde (MDA) levels as compared to normal diet control group. AZ-treated rats significantly (p < 0.001) reduced body weights, cholesterol, triglycerides, pancreatic lipase activity and MDA levels as compared to HFD control. These results suggest that AZ has an antihyperlipidemic action against HFD-induced obesity in rats, possibly through lipid lowering action, reduction of intestinal absorption of dietary fat, and increased antioxidant defense.
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