Effects of spirulina-enriched yogurt on FBS and MDA levels in type 2 diabetic patients
محورهای موضوعی :
Food and Health
Ayda Ghaffari Ashtiani
1
,
Anousheh Sharifan
2
,
Morteza Gharibi
3
,
Rahmatollah MoradZadeh
4
1 - Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Emergency Medicine, School of Health, Arak University of Medical Sciences, Arak, Iran
4 - Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran
تاریخ دریافت : 1401/07/19
تاریخ پذیرش : 1401/09/15
تاریخ انتشار : 1401/09/10
کلید واژه:
/ Diabetes mellitus,
/ Functional foods,
<i>Spirulina platensis</i>,
/ Fermentation,
چکیده مقاله :
Diabetes is a condition where the body cannot regulate blood sugar levels properly due to insufficient or ineffective insulin. This can cause problems with blood lipids and oxidative stress, which damage cells and tissues. Oxidative stress is measured by MDA, a product of lipid peroxidation. Functional foods are foods that have health benefits beyond nutrition. They can modulate physiological functions, enhance immunity, prevent diseases, or improve health outcomes. One of the functional foods that can prevent or reduce the complications of diabetes is spirulina-enriched yogurt, which has antioxidant and hypoglycemic properties. In this study, we chose low-fat yogurt as a functional food and enriched it with spirulina algae powder. Spirulina is a type of blue-green algae that has antioxidant, anti-inflammatory, and hypoglycemic properties. It contains various nutrients, such as protein, vitamins, minerals, and phytochemicals, that can scavenge free radicals and protect cells from oxidative stress. We investigated the effect of daily consumption of spirulina-enriched yogurt on fasting blood sugar (FBS) and serum MDA levels in patients with type 2 diabetes.
منابع و مأخذ:
Saranraj P, Sivasakthi S. Spirulina platensis–food for future: a review. Asian Journal of Pharmaceutical Science and Technology. 2014;4(1):26-33.
Parikh P, Mani U, Iyer U. Role of Spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus. Journal of Medicinal Food. 2001;4(4):193-9.
Aissaoui O, Amiali M, Bouzid N, Belkacemi K, Bitam A. Effect of Spirulina platensis ingestion on the abnormal biochemical and oxidative stress parameters in the pancreas and liver of alloxan-induced diabetic rats. Pharmaceutical Biology. 2017;55(1):1304-12.
Tajvidi E, Nahavandizadeh N, Pournaderi M, Pourrashid AZ, Bossaghzadeh F, Khoshnood Z. Study the antioxidant effects of blue-green algae Spirulina extract on ROS and MDA production in human lung cancer cells. Biochemistry and Biophysics Reports. 2021;28:101139.
Finamore A, Palmery M, Bensehaila S, Peluso I. Antioxidant, immunomodulating, and microbial-modulating activities of the sustainable and ecofriendly spirulina. Oxidative Medicine and Cellular Longevity. 2017;2017.
Karkos PD, Leong SC, Karkos CD, Sivaji N, Assimakopoulos DA. Spirulina in clinical practice: evidence-based human applications. Evidence-Based Complementary and Alternative Medicine. 2011;2011.
Asghari A, Fazilati M, Latifi AM, Salavati H, Choopani A. A review on antioxidant properties of Spirulina. Journal of Applied Biotechnology Reports. 2016;3(1):345-51.
Bitam A, Aissaoui O. Spirulina platensis, oxidative stress, and diabetes. In Diabetes 2020 (pp. 325-331). Academic Press.
Jung F, Krüger-Genge A, Waldeck P, Küpper JH. Spirulina platensis, a super food? Journal of Cellular Biotechnology. 2019;5(1):43-54.
He X, Zhu Y, Jiang X, Qiu Y, Yin F, Xiong W, Liu B, Huang Y. Spirulina compounds show hypoglycemic activity and intestinal flora regulation in type 2 diabetes mellitus mice. Algal Research. 2022;66:102791.
Wan XZ, Li TT, Zhong RT, Chen HB, Xia X, Gao LY, Gao XX, Liu B, Zhang HY, Zhao C. Anti-diabetic activity of PUFAs-rich extracts of Chlorella pyrenoidosa and Spirulina platensis in rats. Food and Chemical Toxicology. 2019;128:233-9.
Sadek KM, Lebda MA, Nasr SM, Shoukry M. Spirulina platensis prevents hyperglycemia in rats by modulating gluconeogenesis and apoptosis via modification of oxidative stress and MAPK-pathways. Biomedicine & Pharmacotherapy. 2017;92:1085-94.
Dario G, Anthonio C, Giuseppe P. Oxidative stress and diabetic vascular complications. Diabetes Care. 1996;19(3):257-67.
Aly HF, Mantawy MM. Comparative effects of zinc, selenium and vitamin E or their combination on carbohydrate metabolizing enzymes and oxidative stress in streptozotocin induced-diabetic rats. European Review for Medical and Pharmacological Sciences. 2012;16(1):66-78.
Gaweł S, Wardas M, Niedworok E, Wardas P. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiadomosci lekarskie (Warsaw, Poland: 1960). 2004;57(9-10):453-5.
Wang J, Zhang X. Free-radical-initiated phospholipid oxidations at the air–water interface: The oxidation of unsaturated and saturated fatty acid chains. The Journal of Physical Chemistry A. 2021;125(4):973-9.
Chen X, Li X, Xu X, Li L, Liang N, Zhang L, Lv J, Wu YC, Yin H. Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation. Free Radical Research. 2021;55(4):405-15.
Rostami HA, Marjani A, Mojerloo M, Rahimi B, Marjani M. Effect of spirulina on lipid Profile, glucose and malondialdehyde levels in type 2 diabetic patients. Brazilian Journal of Pharmaceutical Sciences. 2022;58.
Lee EH, Park JE, Choi YJ, Huh KB, Kim WY. A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients. Nutrition Research and Practice. 2008;2(4):295-300.
Pandey JP, Tiwari A, Mishra G, Mishra RM. Role of Spirulina maxima in the control of blood glucose levels and body weight in streptozotocin induced diabetic male Wistar rats. Journal of Algal Biomass Utilization. 2011;2(4):35-7.
Gheda SF, Abo-Shady AM, Abdel-Karim OH, Ismail GA. Antioxidant and antihyperglycemic activity of Arthrospira platensis (Spirulina platensis) methanolic extract: In vitro and in vivo study. Egyptian Journal of Botany. 2021;61(1):71-93.