سیانوباکتری ها منبعی غنی از داروهای ضد سرطانی
محورهای موضوعی : میکروبیولوژی
1 - گروه بیوتکنولوژی، دانشکده علوم و فناوری¬های همگرا، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
کلید واژه: سرطان, سیانوباکتری ها, ریز جلبکها, متابولیتهای ثانویه, ترکیبات بیواکتیو,
چکیده مقاله :
افزایش میزان مرگ و میر سرطان در نتیجه استفاده بیش از حد از داروهای شیمیایی، آن را به یکی از مرگبارترین بیماری ها در سراسر جهان تبدیل کرده است. به همین دلیل امروزه بیشترین تحقیقات امروزه روی محصولات دارویی طبیعی متمرکز است. در نتیجه هدف از این مقاله، مروری بر خواص ضد سرطانی سیانوباکتری ها در صنعت دارو و درمان است. برای نگارش این مقاله، هم از تجربیات و مقالات نویسندگان مقاله و هم از جدیدترین مقالات موجود در پایگاه های اطلاعاتی Web of Science، Pub Med، Google Scholar، Scopus و ScienceDirect استفاده گردیده است. فرآورده های طبیعی، منبع مهمی از ترکیب های جدید دارویی که نه تنها خود دارای ارزش دارویی هستند، بلکه به عنوان مدل های ساختمانی برای ایجاد آنالوگ های سنتتیک نیز به کار می روند. در این میان، متابولیت های دریایی ثانویه مستخرج از سیانوباکتری ها به عنوان منبع مطلوبی از ترکیبات فعال دارویی بالقوه جدید، دارای تنوع ساختاری و فعالیت های بیولوژیکی متنوع از قبیل خاصیت ضد التهاب، ضد ویروس، ضد میکروب و ویژگی¬های ضد توموری هستند. این مقاله مروری، پتانسیل ترکیبات و متابولیتهای سیانوباکتری ها را به عنوان داروهای ضد سرطان بررسی کرده و ساختار شیمیایی و مکانیسم‌های عمل آن ها را بررسی می‌کند.
The increase in cancer mortality as a result of excessive use of chemical drugs has made it one of the deadliest diseases worldwide. For this reason, most of the research today is focused on natural medicinal products. As a result, the aim of this article is to review the anticancer properties of cyanobacteria in the pharmaceutical and medical industry. To write this article, both the experiences and articles of the authors of the article and the latest articles available in the Web of Science, Pub Med, Google Scholar, Scopus and ScienceDirect databases have been used. Natural products are an important source of new medicinal compounds that not only have medicinal value, but are also used as building models for creating synthetic analogs. In the meantime, secondary marine metabolites extracted from cyanobacteria as a desirable source of potential new medicinal active compounds have structural diversity and diverse biological activities such as anti-inflammatory, antiviral, antimicrobial and anti-tumor properties. This review article examines the potential of compounds and metabolites of cyanobacteria as anticancer drugs and examines their chemical structure and mechanisms of actionof action.
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