سیانوباکتری ها منبعی غنی از داروهای ضد سرطانی
الموضوعات :
1 - گروه بیوتکنولوژی، دانشکده علوم و فناوری¬های همگرا، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
الکلمات المفتاحية: سرطان, سیانوباکتری ها, ریز جلبکها, متابولیتهای ثانویه, ترکیبات بیواکتیو,
ملخص المقالة :
افزایش میزان مرگ و میر سرطان در نتیجه استفاده بیش از حد از داروهای شیمیایی، آن را به یکی از مرگبارترین بیماری ها در سراسر جهان تبدیل کرده است. به همین دلیل امروزه بیشترین تحقیقات امروزه روی محصولات دارویی طبیعی متمرکز است. در نتیجه هدف از این مقاله، مروری بر خواص ضد سرطانی سیانوباکتری ها در صنعت دارو و درمان است. برای نگارش این مقاله، هم از تجربیات و مقالات نویسندگان مقاله و هم از جدیدترین مقالات موجود در پایگاه های اطلاعاتی Web of Science، Pub Med، Google Scholar، Scopus و ScienceDirect استفاده گردیده است. فرآورده های طبیعی، منبع مهمی از ترکیب های جدید دارویی که نه تنها خود دارای ارزش دارویی هستند، بلکه به عنوان مدل های ساختمانی برای ایجاد آنالوگ های سنتتیک نیز به کار می روند. در این میان، متابولیت های دریایی ثانویه مستخرج از سیانوباکتری ها به عنوان منبع مطلوبی از ترکیبات فعال دارویی بالقوه جدید، دارای تنوع ساختاری و فعالیت های بیولوژیکی متنوع از قبیل خاصیت ضد التهاب، ضد ویروس، ضد میکروب و ویژگی¬های ضد توموری هستند. این مقاله مروری، پتانسیل ترکیبات و متابولیتهای سیانوباکتری ها را به عنوان داروهای ضد سرطان بررسی کرده و ساختار شیمیایی و مکانیسم‌های عمل آن ها را بررسی می‌کند.
1. 1. Mondal A, Bose S, Banerjee S, Patra JK, Malik J, Mandal SK, et al. Marine cyanobacteria and microalgae metabolites—A rich source of potential anticancer drugs. Marine drugs. 2020;18(9):476.
2. Qamar H, Hussain K, Soni A, Khan A, Hussain T, Chénais B. Cyanobacteria as natural therapeutics and pharmaceutical potential: Role in antitumor activity and as nanovectors. Molecules. 2021;26(1):247.
3. Khalifa SA, Elias N, Farag MA, Chen L, Saeed A, Hegazy M-EF, et al. Marine natural products: A source of novel anticancer drugs. Marine drugs. 2019;17(9):491.
4. Barreca M, Spanò V, Montalbano A, Cueto M, Díaz Marrero AR, Deniz I, et al. Marine anticancer agents: An overview with a particular focus on their chemical classes. Marine drugs. 2020;18(12):619.
5. Nigam M, Suleria HAR, Farzaei MH, Mishra AP. Marine anticancer drugs and their relevant targets: a treasure from the ocean. DARU Journal of Pharmaceutical Sciences. 2019;27:491-515.
6. Jafari Porzani S, Konur O, Nowruzi B. Cyanobacterial natural products as sources for antiviral drug discovery against COVID-19. Journal of Biomolecular Structure and Dynamics. 2022;40(16):7629-44.
7. Anvar S, Nowruzi B, Tala M. Bioactive products of cyanobacteria and microalgae as valuable dietary and medicinal supplements. Food Hygiene. 2021;11(1 (41)):99-118.
8. Lefranc F, Koutsaviti A, Ioannou E, Kornienko A, Roussis V, Kiss R, et al. Algae metabolites: From in vitro growth inhibitory effects to promising anticancer activity. Natural product reports. 2019;36(5):810-41.
9. Matulja D, Wittine K, Malatesti N, Laclef S, Turks M, Markovic MK, et al. Marine natural products with high anticancer activities. Current Medicinal Chemistry. 2020;27(8):1243-307.
10. Eghtedari M, Porzani SJ, Nowruzi B. Anticancer potential of natural peptides from terrestrial and marine environments: A review. Phytochemistry Letters. 2021;42:87-103.
11. Wali AF, Majid S, Rasool S, Shehada SB, Abdulkareem SK, Firdous A, et al. Natural products against cancer: Review on phytochemicals from marine sources in preventing cancer. Saudi pharmaceutical journal. 2019;27(6):767-77.
12. Nowruzi B, Sarvari G, Blanco S. Applications of cyanobacteria in biomedicine. Handbook of Algal Science, Technology and Medicine: Elsevier; 2020. p. 441-53.
13. Anvar A, Nowruzi B. Bioactive properties of spirulina: A review. Microb Bioact. 2021;4:134-42.
14. Yun CW, Kim HJ, Lee SH. Therapeutic application of diverse marine-derived natural products in cancer therapy. Anticancer Research. 2019;39(10):5261-84.
15. Wang E, Sorolla MA, Gopal Krishnan PD, Sorolla A. From seabed to bedside: A review on promising marine anticancer compounds. Biomolecules. 2020;10(2):248.
16. Shishido TK, Popin RV, Jokela J, Wahlsten M, Fiore MF, Fewer DP, et al. Dereplication of natural products with antimicrobial and anticancer activity from Brazilian cyanobacteria. Toxins. 2019;12(1):12.
17. Dayanidhi DL, Thomas BC, Osterberg JS, Vuong M, Vargas G, Kwartler SK, et al. Exploring the diversity of the marine environment for new anti-cancer compounds. Frontiers in Marine Science. 2021;7:614766.
18. Safavi M, Nowruzi B, Estalaki S, Shokri M. Biological activity of methanol extract from Nostoc sp. N42 and Fischerella sp. S29 isolated from aquatic and terrestrial ecosystems. International Journal on Algae. 2019;21(4).
19. Senousy HH, Abd Ellatif S, Ali S. Assessment of the antioxidant and anticancer potential of different isolated strains of cyanobacteria and microalgae from soil and agriculture drain water. Environmental Science and Pollution Research. 2020;27:18463-74.
20. Bratchkova A, Kroumov AD. Microalgae as producers of biologically active compounds with antibacterial, antiviral, antifungal, antialgal, antiprotozoal, antiparasitic and anticancer activity. Acta Microbiol Bulg. 2020;36(3):79-89.
21. Bajpai VK, Shukla S, Kang S-M, Hwang SK, Song X, Huh YS, et al. Developments of cyanobacteria for nano-marine drugs: Relevance of nanoformulations in cancer therapies. Marine Drugs. 2018;16(6):179.
22. Dyshlovoy SA, Honecker F. Marine compounds and cancer: The first two decades of XXI century. MDPI; 2019. p. 20.
23. Martínez Andrade KA, Lauritano C, Romano G, Ianora A. Marine microalgae with anti-cancer properties. Marine drugs. 2018;16(5):165.
24. Ruiz-Torres V, Encinar JA, Herranz-López M, Pérez-Sánchez A, Galiano V, Barrajón-Catalán E, et al. An updated review on marine anticancer compounds: The use of virtual screening for the discovery of small-molecule cancer drugs. Molecules. 2017;22(7):1037.
25. Abd El-Hack ME, Abdelnour S, Alagawany M, Abdo M, Sakr MA, Khafaga AF, et al. Microalgae in modern cancer therapy: Current knowledge. Biomedicine & Pharmacotherapy. 2019;111:42-50.
26. Nowruzi B, Haghighat S, Fahimi H, Mohammadi E. Nostoc cyanobacteria species: a new and rich source of novel bioactive compounds with pharmaceutical potential. Journal of Pharmaceutical Health Services Research. 2018;9(1):5-12.
27. Ahari H, Nowruzi B, Anvar AA, Porzani SJ. The toxicity testing of cyanobacterial toxins In vivo and In vitro by mouse bioassay: A review. Mini Reviews in Medicinal Chemistry. 2022;22(8):1131-51.
28. Porzani SJ, Lima ST, Metcalf JS, Nowruzi B. In Vivo and In Vitro toxicity testing of cyanobacterial toxins: a mini-review. Reviews of Environmental Contamination and Toxicology Volume 258. 2021:109-50.
29. Saadaoui I, Rasheed R, Abdulrahman N, Bounnit T, Cherif M, Al Jabri H, et al. Algae-derived bioactive compounds with anti-lung cancer potential. Marine drugs. 2020;18(4):197.
30. Alves C, Silva J, Pinteus S, Gaspar H, Alpoim MC, Botana LM, et al. From marine origin to therapeutics: The antitumor potential of marine algae-derived compounds. Frontiers in pharmacology. 2018;9:777.
31. Yao W, Qiu H-M, Cheong K-L, Zhong S. Advances in anti-cancer effects and underlying mechanisms of marine algae polysaccharides. International Journal of Biological Macromolecules. 2022.
32. Zuo W, Kwok HF. Development of marine-derived compounds for cancer therapy. Marine drugs. 2021;19(6):342.
33. Pradhan B, Nayak R, Patra S, Jit BP, Ragusa A, Jena M. Bioactive metabolites from marine algae as potent pharmacophores against oxidative stress-associated human diseases: A comprehensive review. Molecules. 2020;26(1):37.
34. Gopeechund A, Bhagooli R, Neergheen VS, Bolton JJ, Bahorun T. Anticancer activities of marine macroalgae: Status and future perspectives. Biodiversity and Biomedicine. 2020:257-75.
35. Alves C, Diederich M. Marine natural products as anticancer agents. Marine Drugs. 2021;19(8):447.
36. Dyshlovoy SA, Honecker F. Marine compounds and cancer: Updates 2020. MDPI; 2020. p. 643.
37. Pereira RB, Evdokimov NM, Lefranc F, Valentão P, Kornienko A, Pereira DM, et al. Marine-derived anticancer agents: Clinical benefits, innovative mechanisms, and new targets. Marine drugs. 2019;17(6):329.
38. Ahirwar A, Kesharwani K, Deka R, Muthukumar S, Khan MJ, Rai A, et al. Microalgal drugs: A promising therapeutic reserve for the future. Journal of Biotechnology. 2022;349:32-46.
39. Hussein HA, Abdullah MA. Anticancer compounds derived from marine diatoms. Marine Drugs. 2020;18(7):356.
40. Dewi IC, Falaise C, Hellio C, Bourgougnon N, Mouget J-L. Anticancer, antiviral, antibacterial, and antifungal properties in microalgae. Microalgae in health and disease prevention: Elsevier; 2018. p. 235-61.
