The Anti-inflammaging Effects of Lactobacillus Plantarum by Targeting Nrf2 Signaling Pathway
محورهای موضوعی : Food and HealthKiana Lary 1 , مسعود جوانمردی 2
1 - Department of Biology, Faculty of Convergent Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 - Department of Medical Biotechnology, Faculty of Medical Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran
کلید واژه: Inflammaging, Lactobacillus Plantarum, Nrf2 Pathway, Oxidative Stress, Aging,
چکیده مقاله :
Aging is closely associated with chronic low-grade inflammation, a phenomenon termed "inflammaging," which contributes to various age-related diseases. Emerging evidence suggests that gut microbiota, particularly probiotic strains like Lactobacillus plantarum, can modulate inflammatory responses and oxidative stress, potentially mitigating inflammaging. Oxidative stress is widely recognized as a leading factor in inflammation and aging due to an imbalance between oxidants and antioxidants, resulting in senescence-related diseases. Nrf2 plays a pivotal role in regulating antioxidant reactions. The activation of the Nrf2 pathway represents a promising therapeutic approach for preventing senescence-related conditions.
Lactobacillus plantarum from gerobiotics could improve the antioxidant capacity of senescent cells. The focus of this systematic review is centered on exploring the association between specific strains of Lactobacillus plantarum and the Nrf2 pathway and evaluating their potential effects on disease management and anti-inflammaging interventions. By modulating redox homeostasis, L. plantarum may serve as a promising therapeutic strategy to counteract inflammaging and improve healthspan. Further research is warranted to elucidate its molecular mechanisms and potential clinical applications.
Aging is closely associated with chronic low-grade inflammation, a phenomenon termed "inflammaging," which contributes to various age-related diseases. Emerging evidence suggests that gut microbiota, particularly probiotic strains like Lactobacillus plantarum, can modulate inflammatory responses and oxidative stress, potentially mitigating inflammaging. Oxidative stress is widely recognized as a leading factor in inflammation and aging due to an imbalance between oxidants and antioxidants, resulting in senescence-related diseases. Nrf2 plays a pivotal role in regulating antioxidant reactions. The activation of the Nrf2 pathway represents a promising therapeutic approach for preventing senescence-related conditions.
Lactobacillus plantarum from gerobiotics could improve the antioxidant capacity of senescent cells. The focus of this systematic review is centered on exploring the association between specific strains of Lactobacillus plantarum and the Nrf2 pathway and evaluating their potential effects on disease management and anti-inflammaging interventions. By modulating redox homeostasis, L. plantarum may serve as a promising therapeutic strategy to counteract inflammaging and improve healthspan. Further research is warranted to elucidate its molecular mechanisms and potential clinical applications.
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