The Effect of Aerobic Exercise on Homocysteine, C- Reactive Protein and Lipid Profile in Active and Inactive Men

محورهای موضوعی : Report of Health Care

Mehrdad Fathi ¹ , Elham Pouryamehr ²

1 - Department of Sport Physiology, Ferdowsi University of Mashhad, Mashhad, Iran
2 - Department of Sport Physiology, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran

تاریخ دریافت : 1397/06/13 تاریخ پذیرش : 1397/06/16 تاریخ انتشار : 1397/07/09

کلید واژه: Exercise, Lipid Profile, C- Reactive Protein, Homocysteine,

چکیده مقاله :

Introduction: A number of studies have reported that regular aerobic exercises can improve cardiovascular biomarkers such as homocysteine, C- reactive protein and lipid profile. The purpose of this study was to investigate the effect of 4 weeks of aerobic exercise on homocysteine, C- reactive protein and lipid profile in active and inactive men. Methods: in this quasi-experimental study, 26 active (n = 13) and inactive (n = 13) students aged (18- 23) years old participated voluntarily. All subject performed aerobic exercises for 4 weeks, 3 sessions per week and 60 minutes with intensity of 60- 75 % of maximum heart rate reserve per session. Blood sample was taken in the pretest and 24 hours after the last aerobic exercise session in the post- test. Independent sample t- test and paired sample t- test were used to analyze the data (p≤0.05). Results: Serum levels of homocysteine (P = 0.001) and low density lipoprotein cholesterol to high density lipoprotein cholesterol (P = 0.003) significantly decreased in the active group compared to the inactive group. However, there were no significant difference in the changes of C-reactive protein (P = 0.12), low density lipoprotein cholesterol (P = 0.56), triglyceride (P = 0.24), total cholesterol (P = 0.21), total cholesterol to high density lipoprotein (P = 0.52) and triglyceride to high density lipoprotein (P = 0.26), between active and inactive group. Conclusion: It appears that serum levels of homocysteine reduced further after four weeks of exercise in active subjects in comparison with inactive subjects. However, the improvement in the serum levels of C-reactive protein and lipid profiles after four weeks of exercise training were the same in both active and inactive individuals.

منابع و مأخذ:

1. Grundy SM,. Primary prevention of coronary heart disease: integrating risk assessment with intervention. Circulation. 1999; 100 (9): 98- 988.


2. Belmin J. Prevention of cardiovascular disease in elderly. Press Med. 2000; 24: 1234- 1239.


3. Abramson J, Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-aged older us adults. Arch Intern Med. 2002; 162: 1286- 1292.


4. Blake G, Ridker P. Inflammatory bio-marker and cardiovascular risk prediction. J Intern Med. 2002; 52: 283- 294.


5. Mogharnasi M, Gaeini A, Sheikholeslami Vatani D. Comparing the effects of two training methods of aerobic and anaerobic on some pre-inflammatory cytokines in adult male rats. Iranian J Endocrinol Metab. 2010; 11 (2): 191- 198.


6. Rudnicka AR, Rumley A, Lowe GD, Strachan DP. Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, C-reactive protein, tissue plasminogen activator, and von Willebrand factor in a 45-year-old population. Circulation. 2007; 115 (8): 996-1003.


7. Dabidi-Ravshan V, Gaeini A, Ravassi A, Javadi I. Effect of continues training on CRP in vistar 14848 rats. Olympic. 2006; 2: 7- 21.


8. Wilund K. Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?. Clin Sci. 2007; 112: 543- 555.


9. Heald A, Anderson S, Ivison F, Laing I, Gibson J, Cruickshank K. C-reactive protein and the insulin-like growth factor (IGF)-system in relation to risk of cardiovascular disease in different ethnic groups. Atherosclerosis. 2003; 170: 79- 86.


10. Lopez L, Peralta C, Lee A, Aiello A, Haan M. C- reactive protein (CRP) and the prediction of cardiovascular death among mexican- americans. Circulation. 2012; 125: 148.


11. Joubert L, Manore M. Exercise, nutrition, and homocysteine. Int J Sport Nutr Exerc Metab. 2006; 16 (4): 341- 361.


12. Thelma E, Patrick M, Robert W, Ashi R, Robert B, Roberts M. Homocysteine and folic acid are inversely in black woman with preeclampsia. Hypertrnsion. 2004; 43: 1279- 1282.


13. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002; 325 (7374): 1202.


14. Agoston-Coldea L, Mocan T, Dobie L, Marginean ALupu S. The association between homocysteine level and metabolic syndrome in patients of prior myocardial infarction. Rom J Intern Med. 2010; 48: 151- 158.


15. Rodriguez M, Rosety I, Rosety M, Macias I, Cavaco R, Fernieles G, et al. A 12-week aerobic training program reduced serum C-reactive protein in women with metabolic syndrome. Archives Hellenic Med. 2008; 25 (3): 363- 366.


16. Kristin L, Peter T, Cornelia M, Wener M, Catherine M, Foster-Schubert K, et al. No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiol Biomarkers Prev. 2008; 17 (7): 1714- 1718.


17. Hubner-Wozniak E, Ochocki P. Effects of training on resting plasma levels of homocysteine and C-reactive protein in competitive male and female wrestlers. Biomedical Human Kinetics. 2009; 1: 42- 46.


18. Mora S, Lee IM, Buring JE, Ridker PM. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA. 2006; 295 (12): 22- 29.


19. Christopher J, Hammett M, Prapavesis H, Baldi C, Varo N, Schoenbeck U. Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. Am Heart J. 2006; 151 (2): 367.e7- .e16.


20. Goldhammer E, Tanchilevitch A, Maor I, Beniamin Y, Rosenschein U, Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol. 2005; 100 (6): 93- 99.


21. Gallistl S. Changes in serum interleukin-6 concentration in obese children and adolescents during a weight reduction program. Int Obes Relat Metab Disord. 2001; 25 (11): 1640- 1643.


22. Dehghan S. The effect of eight week low impact rhythmic aerobic training on total plasma homocysteine concentration in older non-athlete women. J Mazand Univ Med Sci. 2009; 19 (72): 54- 59.


23. Dastani M. The effect of eight weeks of aerobic training on hsCRP and resistin levels in menopause women. Eur J Ex Biol. 2013; 3 (4): 43- 47.


24. Many G, Hurtado ME, Tanner C, Houmard J, Gordish-Dressman H, Park JJ, et al. Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens. Pediatr Exerc Sci. 2013; 25 (1): 12- 26.


25. Namazi A, Agha Alinejad H, Piry M, Rahbarizadeh F. Effect of short long circles resistance training on serum levels of homocysteine and CRP in active and inactive women. J Endocrinol Metab. 2010; 12 (2): 169- 176.


26. Elliott K. Effects of resistance training and detraining on muscle strength and blood lipid profiles in postmenopausal women. Br J Sports Med. 2002; 36: 340- 345.


27. Couillard C, Despres JP, Lamarche B, Bergeron J, Gagnon J, Leon AS, et al. Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the health, risk factors, exercise training and genetics (HERITAGE) family study. Arterioscler Thromb Vasc Biol. 2001; 21 (7): 1226- 1232.


28. Brooks N, Layne J, Gordon P, Roubenoff R, Nelson M, Castaneda-Sceppa C. Strengthtraining improves muscle quality and insulinsensitivity in Hispanic older adults with type 2diabetes. Int J Med Sci. 2007; 4: 19- 27.


29. Genest J. C-reactive protein: risk factor, biomarker and/or therapeutic target?. Can J Cardiol. 2010; 26: 1- 10.


30. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005; 115 (5): 911- 919.


31. Bruun J, Helge J, Richelsen B, Stallknecht B. Diet and exercise reduce lowgrade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 2006; 290 (5): E961- E967.


32. Myers J. Exercise and cardiovascular health. Circulation. 2003; 107: e2- e5.