Comparative analysis of PET image characteristics using two types of crystals BGO and LYSO with GEANT4 simulation
محورهای موضوعی : Photon Therapy, Diagnosis and EquipmentMohammad Golshanipour 1 , sharifeh shahi 2
1 -
2 -
کلید واژه: Simulation, GEANT4, imaging system, PET, nuclear medicine,
چکیده مقاله :
PET imaging, or positron emission tomography, is a nuclear medical imaging technique that uses radiotracers to observe the body's metabolic and physiological activities in real-time. PET detectors are a crucial component of PET (positron emission tomography) imaging systems, used for the detection and tracking of diseases. Different scintillation crystals are used in PET systems, each with its own advantages and disadvantages. In this study, various parameters in forming an optimal image using two crystals, BGO and LSO, are examined. In this study, GEANT4 simulation is used to compare the two crystals, BGO and LYSO, in terms of parameters such as optical yield, decay time, energy resolution, contrast, accuracy, and more. The goal is to select the best crystal for the mentioned criteria. The simulation results are presented through various charts. The charts include energy deposition in crystals based on event IDs, energy deposition in individual crystal blocks, energy distribution plots, and patient dose distribution charts. The results highlight BGO's advantages in terms of smoother curves, increased interactions, and higher averages. The choice between LYSO and BGO involves trade-offs, and the decision should be based on specific priorities such as energy resolution, timing, cost, and overall performance.
[1] TOWNSEND, D. W., et al. Physical principles and technology of clinical PET imaging. Annals-Academy of Medicine Singapore, 2004, 33.2: 133-145.
[2] BASU, Sandip, et al. Fundamentals of PET and PET/CT imaging. Annals of the New York Academy of Sciences, 2011, 1228.1: 1-18
[3] GUNDACKER, S., et al. Time resolution deterioration with increasing crystal length in a TOF-PET system. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2014, 737: 92-100.
[4] MELCHER, Charles L. Scintillation crystals for PET. Journal of Nuclear Medicine, 2000, 41.6: 1051-1055.
[5] AHMED, Abdella M., et al. A validated Geant4 model of a whole-body PET scanner with four-layer DOI detectors. Physics in Medicine & Biology, 2020, 65.23: 235051.
[6] . MARSDEN, Paul K. Detector technology challenges for nuclear medicine and PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2003, 513.1-2: 1-7
[7] TOWNSEND, David W., et al. A rotating PET scanner using BGO block detectors: design, performance and applications. Journal of Nuclear Medicine, 1993, 34.8: 1367-1376.
[8] . TURKINGTON, Timothy G., et al. Performance of a BGO PET/CT with higher resolution PET detectors. In: IEEE Nuclear Science Symposium Conference Record, 2005. IEEE, 2005. p. 4 pp.-1894
[9] . DU, Junwei, et al. Physical properties of LYSO scintillator for NN-PET detectors. In: 2009 2nd international conference on biomedical engineering and informatics. IEEE, 2009. p. 1-5
[10] DU, Junwei, et al. Performance comparison of dual-ended readout depth-encoding PET detectors based on BGO and LYSO crystals. Physics in Medicine & Biology, 2020, 65.23: 235030.
[11] BHATNAGAR, Sonali; SIRISHA, S. N. L. GEANT4 & GAMOS—A particle implementation of high energy simulation toolkit to oncology therapy. In: Proceedings of the 2014 IEEE Students' Technology Symposium. IEEE, 2014. p. 25-30.
[12] MCNAMARA, A. L., et al. Towards optimal imaging with PET: an in silico feasibility study. Physics in Medicine & Biology, 2014, 59.24: 7587.
[13] STEINBERG, Jeffrey. MRI-Based Attenuation Correction for PET Reconstruction. 2008. PhD Thesis. The Ohio State University.
[14] ANDRIESSEN, J.; DORENBOS, P.; VAN EIJK, C. W. E. Calculation of energy levels of cerium in inorganic scintillator crystals. MRS Online Proceedings Library (OPL), 1994, 348: 355.
[15] DERENZO, Stephen E.; KLINTENBERG, Mattias; WEBER, Marvin J. Ab-initio cluster calculations of hole formation and trapping in PbF/sub 2/and PbF/sub 4. In: 1998 IEEE Nuclear Science Symposium Conference Record. 1998 IEEE Nuclear Science Symposium and Medical Imaging Conference (Cat. No. 98CH36255). IEEE, 1998. p. 163-167.
[16] ARIÑO-ESTRADA, Gerard, et al. Study of Čerenkov light emission in the semiconductors TlBr and TlCl for TOF-PET. IEEE transactions on radiation and plasma medical sciences, 2020, 5.5: 630-637.
[17] BERGER, M. J., et al. Stopping-power and range tables for electrons, protons, and helium ions, NIST Standard Reference Database 124. National Institute of Standards and Technology (NIST), Physical Measurement Laboratory (PML), 2017.
[18] BRUNNER, S. E.; SCHAART, D. R. BGO as a hybrid scintillator/Cherenkov radiator for cost-effective time-of-flight PET. Physics in Medicine & Biology, 2017, 62.11: 4421.
[19] CATES, Joshua W., et al. Improved single photon time resolution for analog SiPMs with front end readout that reduces influence of electronic noise. Physics in Medicine & Biology, 2018, 63.18: 185022.
[20] EFTHIMIOU, Nikos, et al. TOF-PET image reconstruction with multiple timing kernels applied on Cherenkov radiation in BGO. IEEE transactions on radiation and plasma medical sciences, 2020, 5.5: 703-711.
[21] PAGANO, Fiammetta, et al. Advances in heterostructured scintillators: toward a new generation of detectors for TOF-PET. Physics in Medicine & Biology, 2022, 67.13: 135010.
[22] ENOCH, S., et al. Design considerations for a new generation of SiPMs with unprecedented timing resolution. Journal of Instrumentation, 2021, 16.02: P02019.
[23] GOLA, Alberto, et al. NUV-sensitive silicon photomultiplier technologies developed at Fondazione Bruno Kessler. Sensors, 2019, 19.2: 308.
[24] KRATOCHWIL, Nicolaus; GUNDACKER, Stefan; AUFFRAY, Etiennette. A roadmap for sole Cherenkov radiators with SiPMs in TOF-PET. Physics in Medicine & Biology, 2021, 66.19: 195001.