طب سنتی، سارس کووید2 و سیستم ایمنی انسان
محورهای موضوعی : طب سنتی
مژده لشکری
1
,
اشرف کریمی نیک
2
,
محمد جواد سلطانی بناوندی
3
1 - دانشجوی دکتری، گروه میکروبیولوژی، واحد کرمان، دانشگاه آزاد اسلامی، کرمان، ایران
2 - دانشیار، گروه میکروبیولوژی، واحد کرمان، دانشگاه آزاد اسلامی، کرمان، ایران
3 - استادیار، گروه میکروبیولوژی، واحد کرمان، دانشگاه آزاد اسلامی، کرمان، ایران
کلید واژه: سارس کووید2, طب سنتی, ایمنی,
چکیده مقاله :
سارس کووید2 که به‌عنوان ویروس کرونا نیز شناخته می‌شود، یک ویروس تنفسی است که برای اولین بار در دسامبر 2019 در ووهان چین، شناسایی شد. این ویروس می‌تواند باعث بیماری‌های خفیف تا شدید تنفسی و در برخی موارد منجر به مرگ شود. علائم شایع آن شامل: تب، سرفه و تنگی نفس است. طب سنتی به‌عنوان یک رویکرد مکمل در مدیریت بیماری‌ها، به‌ویژه در زمان‌های بحران بهداشتی، اهمیت پیدا کرده است. بسیاری از افراد به دنبال درمان‌های طبیعی و روش‌های پیشگیری از بیماری‌ها هستند. در طب سنتی، از گیاهان دارویی، رژیم غذایی مناسب و تکنیک‌های آرامش‌بخش برای تقویت سیستم ایمنی و بهبود سلامت استفاده می‌شود. ویروس سارس کووید2، عامل بیماری کووید-19، تأثیرات عمیقی بر سلامت عمومی و سیستم ایمنی انسان دارد. طب سنتی، با تأکید بر استفاده از گیاهان دارویی و روش‌های طبیعی، به تقویت سیستم ایمنی و پیشگیری از بیماری‌ها کمک می‌کند. در این راستا، برخی از گیاهان و ترکیبات طبیعی می‌توانند به بهبود عملکرد سیستم ایمنی و کاهش عوارض ناشی از عفونت‌های ویروسی کمک کنند. این گیاهان و ترکیبات طبیعی معمولاً به‌عنوان مکمل درمان‌های پزشکی استفاده می‌شوند. به‌کارگیری این گیاهان در کنار درمان‌های مدرن و اقدامات بهداشتی، می‌تواند به بهبود عملکرد سیستم ایمنی و کاهش شدت عوارض ویروس سارس کووید2 کمک کند. با توجه به اهمیت این موضوع، شناخت و استفاده از روش‌های طبیعی می‌تواند به‌عنوان یک مکمل در کنار درمان‌های مدرن، مورد توجه قرار گیرد. با این حال، مهم است که به یاد داشته باشیم که طب سنتی نمی‌تواند جایگزین درمان‌های پزشکی مدرن شود و همواره باید تحت نظر پزشک و با مشاوره متخصصان طب سنتی انجام شود.
SARS-CoV-2, also known as the coronavirus, is a respiratory virus that was first identified in December 2019 in Wuhan, China. This virus can cause mild to severe respiratory illnesses and, in some cases, lead to death. Common symptoms include fever, cough, and shortness of breath. Traditional medicine, as a complementary approach to disease management, has gained importance, especially during health crises. Many people are seeking natural treatments and methods for disease prevention. In traditional medicine, medicinal plants, proper diet, and relaxation techniques are used to strengthen the immune system and improve health. The SARS-CoV-2 virus, the cause of COVID-19, has profound effects on public health and the human immune system. Traditional medicine, with an emphasis on the use of medicinal plants and natural methods, helps boost the immune system and prevent diseases. In this regard, some plants and natural compounds can improve immune function and reduce the complications caused by viral infections. These plants and natural compounds are often used as supplements to medical treatments. The incorporation of these plants alongside modern treatments and health measures can help improve immune function and reduce the severity of the effects of the SARS-CoV-2 virus. Given the importance of this topic, recognizing and using natural methods can be considered as a complement to modern treatments. However, it is essential to remember that traditional medicine cannot replace modern medical treatments and should always be practiced under the supervision of a physician and with the guidance of traditional medicine specialists
References
1. Swain SK, Jena PP. Clinical implications and future perspective of COVID-19 pandemic-a review. International Journal of Advances in Medicine. 2021;8(2):334-40.
2. Wang D, Huang J, Yeung AW, Tzvetkov NT, Horbańczuk JO, Willschke H, Gai Z, Atanasov AG.The significance of natural product derivatives and traditional medicine for COVID-19. Processes. 2020;8(8):937.
3. Robinson PC, Liew DF, Tanner HL, Grainger JR, Dwek RA, Reisler RB, Steinman L, Feldmann M, Ho LP, Hussell T, Moss P. COVID-19 therapeutics: Challenges and directions for the future. Proceedings of the National Academy of Sciences. 2022;119(15):e2119893119.
4. Buso P, Manfredini S, Reza Ahmadi-Ashtiani H, Sciabica S, Buzzi R, Vertuani S, Baldisserotto A. Iranian medicinal plants: from ethnomedicine to actual studies. Medicina. 2020;56(3):97.
5. Shi J, Yang Y, Zhou X, Zhao L, Li X, Yusuf A, Hosseini MS, Sefidkon F, Hu X. The current status of old traditional medicine introduced from Persia to China. Frontiers in Pharmacology. 2022;13:953352.
6. Houghton PJ. The role of plants in traditional medicine and current therapy. The Journal of Alternative and Complementary Medicine. 1995;1(2):131-43.
7. Patwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: a comparative overview. Evidence‐Based Complementary and Alternative Medicine. 2005;2(4):465-73.
8. Zhu Y-P, Woerdenbag HJ. Traditional Chinese herbal medicine. Pharmacy World and Science. 1995;17:103-12.
9. Patwardhan B, Mashelkar RA. Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug discovery today. 2009;14(15-16):804-11.
10. Metwaly AM, Ghoneim MM, Eissa IH, Elsehemy IA, Mostafa AE, Hegazy MM, Afifi WM, Dou D. Traditional ancient Egyptian medicine: A review. Saudi journal of biological sciences. 2021;28(10):5823-32.
11. Hamedi A, Zarshenas MM, Sohrabpour M, Zargaran A. Herbal medicinal oils in traditional Persian medicine. Pharmaceutical biology. 2013;51(9):1208-18.
12. Abdullahi AA. Trends and challenges of traditional medicine in Africa. African journal of traditional, complementary and alternative medicines. 2011;8(5S).
13. Debnath S, Chakravorty R, Devi D. A Review on role of medicinal plants in immune system. Asian Journal of Pharmacy and Technology. 2020;10(4):273-7.
14. Chaplin DD. Overview of the immune response. Journal of allergy and clinical immunology. 2010;125(2):S3-S23.
15. Singh MR, Yadav K, Chaurasiya ND, Singh D. Immune system and mechanism of immunomodulation. Plants and Phytomolecules for Immunomodulation: Recent Trends and Advances: Springer; 2022. p. 1-31.
16. Sharma P, Kumar P, Sharma R, Gupta G, Chaudhary A. Immunomodulators: role of medicinal plants in immune system. National Journal of Physiology, Pharmacy and Pharmacology. 2017;7(6):552.
17. Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Alternative medicine review. 2006;11(2):128.
18. Ahmed S, Rai KR. Interferon in the treatment of hairy-cell leukemia. Best practice & research clinical haematology. 2003;16(1):69-81.
19. Mukherjee PK, Nema NK, Bhadra S, Mukherjee D, Braga FC, Matsabisa MG. Immunomodulatory leads from medicinal plants. 2014; Indian Journal of Traditional Knowledge, 13(2): 235-256.
20. Bahramsoltani R, Rahimi R. An evaluation of traditional Persian medicine for the management of SARS-CoV-2. Frontiers in pharmacology. 2020;11:571434.
21. Helmy YA, Fawzy M, Elaswad A, Sobieh A, Kenney SP, Shehata AA. The COVID-19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control. Journal of clinical medicine. 2020;9(4):1225.
22. Mirzaei R, Karampoor S, Sholeh M, Moradi P, Ranjbar R, Ghasemi F. A contemporary review on pathogenesis and immunity of COVID-19 infection. Molecular biology reports. 2020;47(7):5365-76.
23. Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. Journal of pharmaceutical analysis. 2020;10(2):102-8.
24. Dzieciatkowski T, Szarpak L, Filipiak KJ, Jaguszewski M, Ladny JR, Smereka J. COVID-19 challenge for modern medicine. Cardiology Journal. 2020;27(2):175-83.
25. Singh NA, Kumar P, Jyoti, Kumar N. Spices and herbs: potential antiviral preventives and immunity boosters during COVID‐19. Phytotherapy Research. 2021;35(5):2745-57.
26. Dabaghian F, Hasanpour M, Maroufizadeh S, Joulani MH. Use of medicinal plants and its association with health literacy in the general population of Iran during the COVID-19 pandemy: a web-based cross-sectional survey. Research Journal of Pharmacognosy. 2023;10(1):31-40.
27. Dehghan M, Ghanbari A, Heidari FG, Shahrbabaki PM, Zakeri MA. Use of complementary and alternative medicine in general population during COVID-19 outbreak: A survey in Iran. Journal of integrative medicine. 2022;20(1):45-51.
28. Gholami-Ahangaran M, Karimi-Dehkordi M. A review on phytogenic compounds inhibit SARS, MERS and Covid-19 coronaviruses. Journal of Arak University of Medical Sciences. 2023;26(1):125-140.
29. Wang Z, Yang L. Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts. Journal of Ethnopharmacology. 2021;270:113869.
30. Verma S, Twilley D, Esmear T, Oosthuizen CB, Reid AM, Nel M, Lall N. Anti-SARS-CoV natural products with the potential to inhibit SARS-CoV-2 (COVID-19). Frontiers in Pharmacology. 2020;11:561334.
31. Alzghari SK, Acuna VS. Supportive treatment with tocilizumab for COVID-19: a systematic review. Journal of Clinical Virology. 2020;127:104380.
32. Feldmann M, Maini RN, Woody JN, Holgate ST, Winter G, Rowland M, Richards D, Hussell T. Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed. The Lancet. 2020;395(10234):1407-9.
33. Hadjadj J, Yatim N, Barnabei L, Corneau A, Boussier J, Smith N, Péré H, Charbit B, Bondet V, Chenevier-Gobeaux C, Breillat P. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. Science. 2020;369(6504):718-24.
34. Hu B, Huang S, Yin L. The cytokine storm and COVID‐19. Journal of medical virology. 2021;93(1):250-6.
35. Collora JA, Liu R, Albrecht K, Ho Y-C. The single-cell landscape of immunological responses of CD4+ T cells in HIV versus severe acute respiratory syndrome coronavirus 2. Current Opinion in HIV and AIDS. 2021;16(1):36-47.
36. Velazquez-Salinas L, Verdugo-Rodriguez A, Rodriguez LL, Borca MV. The role of interleukin 6 during viral infections. Frontiers in Microbiology. 2019;10:1057.
37. Lu LF, Liston A. MicroRNA in the immune system, microRNA as an immune system. Immunology. 2009;127(3):291-8.
38. Asadpour-Behzadi A, Kariminik A, Kheirkhah B. MicroRNA-155 and 194 alter expression of Th17 and T regulatory-related transcription factors in the patients with severe coronavirus disease 2019 (COVID-19). Immunobiology. 2023;228(2):152343.
39. Sarrafi O, Kariminik A, Arababadi MK. Role of microRNA-16-5p, microRNA-194, IP-10 and APRIL in inducing inflammation in SARS-CoV-2 infected patients with severe symptoms. 2023; Indian Journal of Experimental Biology. 2023;61(11): 888-892.
40. Sarrafi O, Kariminik A, Arababadi MK. Systematic levels of IL-29 and microRNA185-5p were not associated with severe COVID-19 in the Iranian population. Virology Journal. 2023;20(1):88.
41. Lashkari M, Kariminik A, Soltani-Banavandi MJ. Evaluation of suppressor of cytokine signaling 1, interleukin-29 and lysosomal trafficking regulator in severe COVID-19. Journal of Kermanshah University of Medical Sciences.2024;28(4): e145333.
42. Lashkari M, Kariminik A, Banavandi MJ. The potential roles played by miR-2113 and miR-568 in the severe SARS-CoV-2 infection pathogenesis. Clinical Laboratory. 2023;69(11)::2261-2265.
43. Sabbar ZS, Kariminik A, Ghane M. The roles played by hsa-miR-223-5p and mutations in the S gene of SARS-CoV-2 in COVID-19. Laboratory Medicine. 2024:lmae066.
44. Nahavandi-Parizi P, Kariminik A, Montazeri M. Retinoic acid-inducible gene 1 (RIG-1) and IFN-β promoter stimulator-1 (IPS-1) significantly down-regulated in the severe coronavirus disease 2019 (COVID-19). Molecular Biology Reports. 2023;50(1):907-11.
