Antioxidant properties and anticancer activity of Olea europaea L. olive and Ficus carica fruit extracts against pancreatic cancer cell lines

محورهای موضوعی : Medicinal and Herbal Plants

Nadia Dekdouk ¹ , Souad Ameddah ² , Chawki Bensouici ³ , Meghboun Ibtissem ⁴ , Menad Ahmed ⁵ , Fatima Martel ⁶

1 - Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri Constantine1, Algérie
2 - Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri Constantine1, Algérie
3 - Biotechnology Research Center (CRBt), Ali Mendjli, Constantine, Algérie
4 - Biotechnology Research Center (CRBt), Ali Mendjli, Constantine, Algérie
5 - Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri Constantine1, Algérie
6 - Unit of Biochemistry, Dept. of Biomedicine, Faculty of Medicine of Porto 4200-319 Porto, portugal

تاریخ دریافت : 1402/08/25 تاریخ پذیرش : 1403/03/23 تاریخ انتشار : 1403/06/31

کلید واژه: Antioxidant capacity, Anti-pancreatic cancer effect, Antiproliferative, Cytotoxic, Fig extract, Olive extract, Phytochemical composition,

چکیده مقاله :

Olea europaea (OFE) and Ficus carica (FFE) extracts have shown anticancer activity. In the currents report, we aim to evaluate the phytochemical composition, antioxidant properties and anticancer activity of OFE and FFE against PANC-1 and AsPC-1 pancreatic cancer cell lines. OFE possessed higher phenolic, flavonoid content and antioxidant ability than FFE. OFE and FFE induced a cytotoxic effect and their combination resulted in an increased cytotoxicity. OFE showed an antiproliferative effect while FFE had no effect. Combination of the two extracts resulted in an antiproliferative effect similar to that of OFE. OFE showed an antimigratory effect, while FFE exhibited a promigratory effect. Interestingly, combination of the two extracts resulted in an anti-migratory effect similar to that caused by OFE. In view of the findings of this study, these extracts could be considered potential sources of natural compounds with antioxidant and anti-pancreatic cancer effects. The combination of these extracts should be further investigated in the context of pancreatic cancer.

چکیده انگلیسی:

Olea europaea (OFE) and Ficus carica (FFE) extracts have shown anticancer activity. In the currents report, we aim to evaluate the phytochemical composition, antioxidant properties and anticancer activity of OFE and FFE against PANC-1 and AsPC-1 pancreatic cancer cell lines. OFE possessed higher phenolic, flavonoid content and antioxidant ability than FFE. OFE and FFE induced a cytotoxic effect and their combination resulted in an increased cytotoxicity. OFE showed an antiproliferative effect while FFE had no effect. Combination of the two extracts resulted in an antiproliferative effect similar to that of OFE. OFE showed an antimigratory effect, while FFE exhibited a promigratory effect. Interestingly, combination of the two extracts resulted in an anti-migratory effect similar to that caused by OFE. In view of the findings of this study, these extracts could be considered potential sources of natural compounds with antioxidant and anti-pancreatic cancer effects. The combination of these extracts should be further investigated in the context of pancreatic cancer.

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