Construction and Characterization of polyvinyl alcohol-sodium alginate magnetic hydrogel for use in release of famotidine
محورهای موضوعی : شیمی داروئی
Mahdiyeh Poorgholam
1
(Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran)
Masoud Mokhtary
2
(Department of Chemistry, Rasht Branch, Islamic Azad University, PO Box 41325-3516, Rasht, IRAN)
mohammad alikarami
3
(Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran.)
کلید واژه: Sodium alginate, Polyvinylalcohol, Magnetic hydrogel, Famotidine, Drug release,
چکیده مقاله :
Abstract Polyvinyl alcohol-sodium alginate magnetic hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide and Fe3O4 nanoparticles. The magnetic polyvinyl alcohol-sodium alginate (nano-Fe3O4/PVA-SA) hydrogel was characterized by FTIR, SEM, and EDX methods. Also, magnetic characterization of the synthesized nanoFe3O4/PVA-SA hydrogel was identified by vibrating sample magnetometer (VSM) method. Then, loading and release of famotidine drug was studied by nano-Fe3O4/PVA-SA hydrogel. The FT-IR results confirmed the formation of nano-Fe3O4/PVA-SA hydrogel. The effects of temperature and pH on the loading and release of famotidine drug in gelatin-polyvinylalcohol magnetic hydrogel were studied. The polyvinyl alcohol-sodium alginate magnetic hydrogel is sensitive to pH and temperature and provides the controlled release of famotidine. The results showed that the highest drug loading was achieved at 37 °C after 6 hours. Farther more, the highest drug release rate was obtained after 6 hours at 37 °C at pH = 2 with 57.95 ppm.
Abstract Polyvinyl alcohol-sodium alginate magnetic hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide and Fe3O4 nanoparticles. The magnetic polyvinyl alcohol-sodium alginate (nano-Fe3O4/PVA-SA) hydrogel was characterized by FTIR, SEM, and EDX methods. Also, magnetic characterization of the synthesized nanoFe3O4/PVA-SA hydrogel was identified by vibrating sample magnetometer (VSM) method. Then, loading and release of famotidine drug was studied by nano-Fe3O4/PVA-SA hydrogel. The FT-IR results confirmed the formation of nano-Fe3O4/PVA-SA hydrogel. The effects of temperature and pH on the loading and release of famotidine drug in gelatin-polyvinylalcohol magnetic hydrogel were studied. The polyvinyl alcohol-sodium alginate magnetic hydrogel is sensitive to pH and temperature and provides the controlled release of famotidine. The results showed that the highest drug loading was achieved at 37 °C after 6 hours. Farther more, the highest drug release rate was obtained after 6 hours at 37 °C at pH = 2 with 57.95 ppm.
1. Campoccia D, Doherty P, Radice M, Brun P, Abatangelo G, Williams DF.
Semisynthetic resorbable materials from hyaluronan esterification. Biomaterials.1998;19:
2101-27.
2. Prestwich GD, Marecak DM, Marecak JF, Vercruysse KP, Ziebell MR. Controlled
chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of
hydrazide derivatives. Journal of Controlled Release. 1998;53:93-103.
3. M.M. Lakouraj, M. Tajbakhsh, M. Mokhtary, Synthesis and swelling characterization
of cross-linked PVP/PVA hydrogels. Iranian Polymer Journal. 2005;14:1022-30.
4. Wangkaya R, Chuysinuan P, Pengsuk C, Techasakul S, Lirdprapamongkol K, Srvasti J,
Nooeaid P. Electrospinning of alginate/soy protein isolated nanofibers and their release
characteristics for biomedical applications. Journal of Science: Advanced Materials and
Devices. 2017;2:309–16.
5. Medeiros SF, Santos AM, Fessi H, Elaissari A, Stimuli-responsive magnetic particles
for biomedical applications. International Journal of Pharmaceutics. 2011;403: 139-61.
Masoud Mokhtary, et al., J. Appl. Chem. Res., 18, 3, 43-55 (2024)
54
6. Neuberger T, Schöpf B, Hofmann H, Hofmann M, von Rechenberg B.
Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a
new drug delivery system. Journal of Magnetism and Magnetic Materials. 2005;293: 483-96.
7. Masoumi B, Mokhtary M, Preparation and characterization of magnetic gelatinpolyvinyl alcohol hydrogel for using in the release of furosemide drug. Journal of Applied
Chemical Research. 2023;17: 8-20.
8. Laurent S, Bridot JL, Muller RN. Magnetic iron oxide nanoparticles for biomedical
applications. Future Medicinal Chemistry. 2010;2: 427-49.
9. Zhao X, Kim J, Cezar CA, Huebsch N, Lee K, Bouhadir K, Mooney DJ. Active
scaffolds for on-demand drug and cell delivery. Proceedings of the National Academy of
Sciences of the United States of America. 2011;108: 67-72.
10. Weigel T, Mohr R, Lendlein A. Investigation of parameters to achieve temperatures
required to initiate the shape-memory effect of magnetic nanocomposites by inductive heating.
Smart Materials and Structures. 2009;18:025011.
11. Hernandez R, Sacristan J, Asin L, Torres TE, Ibarra MR, Goya GF, Mijangos C.
Magnetic hydrogels derived from polysaccharides with improved specific power absorption:
potential devices for remotely triggered drug delivery. The Journal of Physical Chemistry
B. 2010;114: 12002-007.
12. Meyer DE, Shin BC, Kong GA, Dewhirst MW, Chilkoti A. Drug targeting using
thermally responsive polymers and local hyperthermia. Journal of Controlled Release.
2002;74: 213-24.
13. Das M, Senapati P. Furosemide-loaded Alginate Microspheres Prepared by Ionic Crosslinking Technique: Morphology and Release Characteristics. Indian Journal of Pharmaceutical
Sciences. 2008;70:77-84.
14. Ali S Taha, Caroline McCloskey, Rakesh Prasad, Vladimir Bezlyak, Famotidine for the
prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a
phase III, randomised, double-blind, placebo-controlled trial. Lancet 2009; 374:119–25.
15. Bhagwat R, Vaidhya I. Novel Drug Delivery Systems: an Overview. International
Journal of Pharmaceutical Sciences and Research, 2013;4: 970-82.
16. Bezerra ICS, Moma MSM, Freitas ED, Silva MGC, Vieira MGA. Development of a
modified drug delivery system through the incorporation of furosemide into sericin and
alginate matrix using the experimental design approach. Journal of Chemical
Technology & Biotechnology. 2021;96: 650-661.
Masoud Mokhtary, et al., J. Appl. Chem. Res., 18, 3, 43-55 (2024)
55
17. Meka L, Kesavan B, Kalamata VN, Mohaneaga C, Bandari S, Vobalaboina V, Yamsani
MR. Design and evaluation of polymeric coated minitablets as multiple unit gastroretentive
floating drug delivery systems for furosemide. Journal of Pharmaceutical Sciences.2009;98:
2122-32.
18. Peppas NA, Zach Hilt J, Khademhosseini A, Langer R. Hydrogels in biology and
medicine: from molecular principles to bionanotechnology. Advanced Materials.
2006;18:1345-60.
19. Devarakonda B, Otto DP, Judefeind A, Hill RA, de Villiers MM. Effect of pH on the
solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexes.
International Journal of Pharmaceutics. 2007;345:142-53.
