اثر موسیقی آرام روان (Adagio) و تند دوان (Allegro) بر میزان ولع مصرف در موش های سوری نر بالغ مصرف کننده متامفتامین
محورهای موضوعی : فصلنامه زیست شناسی جانوریسیده صدیقه شجاعی 1 , سید ابراهیم حسینی 2
1 - گروه روان شناسی، واحد مرودشت، دانشگاه آزاد اسلامی، مرودشت، ایران
2 - گروه زیست شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
کلید واژه: موسیقی, موش صحرایی, متامفتامین, ولع مصرف,
چکیده مقاله :
امروزه میلیون ها نفر در سراسر دنیا متامفتامین را به عنوان دارو و یا در جهت کسب لذت مورد سوءمصرف قرار می دهند. با توجه به عوارض جانبی و اعتیاد آوری شدید این ماده، مطالعه حاضر با هدف بررسی اثر موسیقی آرام روان و تند دوان بر میزان ولع مصرف در موش های سوری تحت تیمار با متامفتامین صورت گرفت. این یک مطالعه تجربی است که در سال 1395 در دانشگاه آزاد اسلامی واحد مرودشت بر روی 70 سر موش سوری نر بالغ در گروه های کنترل (فاقد تیمار)، شاهد (تیمار با حلال دارو) و 5 گروه تجربی دریافت کننده 1 میلی گرم بر کیلوگرم متامفتامین، تحت تاثیر موسیقی آرام روان، موسیقی تند دوان، موسیقی آرام روان با متامفتامین و موسیقی تند دوان با متامفتامین قرار گرفتند. در این مطالعه جهت سنجش میزان ولع مصرف از روش ترجیح مکان شرطی استفاده گردید. در پایان داده ها با استفاده از آزمون های ANOVA و توکی و با کمک نرم افزارSPSS 18 با معناداری اختلاف داده ها در سطح 05/0≤ p ارزیابی شدند. نتایج نشان داد که متامفتامین و موسیقی آرام روان به تنهایی و با یکدیگر و همچنین موسیقی تنددوان با متامفتامین، باعث افزایش معنادار ترجیح مکان شرطی در سطح 01/0p< نسبت به گروه کنترل می شود در حالی که موسیقی تند دوان به تنهایی فاقد تاثیر معنادار می باشد. موسیقی و متامفتامین احتمالا با تحریک سیستم های اکسی توسینی و دوپامینی مغز باعث افزایش ترجیح مکان شرطی می شوند لذا احتمالا از موسیقی آرام روان می توان به عنوان روشی بی خطر در جهت کاهش ولع مصرف در بیماران سوء مصرف کننده استفاده نمود.
Nowadays, millions of people around the world abused methamphetamine as drug in order to enjoy the day. With regard to the side and addictive effects of this drug, this study aimed to investigate the effects of Adagio and Allegro music on craving consumption in rats treated with methamphetamine. This experimental study was performed in Islamic Azad University of Marvdasht, Iran in 2016. Overall, 70 adult male rats were divided into control group (no treatment), sham (treated with a solvent) and 5 experimental groups receiving 1mg/kg methamphetamine influenced Adagio music, Allegro music, Adagio music with methamphetamine and Allegro music with methamphetamine. To assess craving consumption, conditioned place preference method was used. At the end, the data were evaluated using ANOVA and Tukey-test using SPSS-18. Significant differences of data at P≤0.05 were observed from the data analysis. Using methamphetamine and Adagio music alone and with each other as well as Allegro music with methamphetamine resulted in a significant increase Conditioned Place Preference at P≤0/01 compared to the control group while the Allegro music alone showed no significant effect. Music and methamphetamine probably by stimulating oxytocin and dopamine systems of the brain caused to increase the conditioned place preference; therefore, likely Adagio music can be employed as a safe way to reduce craving consumption in abusers.
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