Simulation of Drug Release in Expanding Hydrogels Containing Chitosan and Gelatin

محورهای موضوعی :

Thair Aljawahiry ¹ , Mohaned Adil ² , Mohammed Abdulkadhim Sayah ³ , Abed J. Kadhim ⁴ , Mazin Abdullateef Alzubaidi ⁵ , Ahmed S. Abed ⁶ , Naseer Mehdi Mohammed ⁷

1 - College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
2 - College of Pharmacy, Al-Farahidi University, Baghdad, Iraq
3 - Al-Manara College for Medical Sciences, Maysan, Iraq
4 - Al-Nisour University College, Baghdad, Iraq
5 - Department of Anesthesia, Al-Mustaqbal University, Babylon, Iraq
6 - Hilla University College, Babylon, Iraq, Department of Prosthetic Dental Technology, Iraq
7 - Mazaya University College, Nasiriyah, Iraq

تاریخ دریافت : 1401/12/25 تاریخ پذیرش : 1402/05/09 تاریخ انتشار : 1402/06/10

کلید واژه: Drug release, Gelatin, Expanding hydrogels, Chitosan,

چکیده مقاله :

Utilizing mathematical modeling of drug release is one method for accelerating the rate of drug diffusion and penetration in hydrogel-based systems. This method facilitates a greater comprehension of drug control mechanisms and their release. Hydrogels are expanding biomaterials that necessitate regulation for use in drug release. The current study's objective is to model drug release in swelling hydrogels containing combinations of chitosan and gelatin polymers; with the aid of this simulation, the release time and concentration of the drug can be predicted. This modeling examined changes in the concentration of drugs in various hydrogels. For this simulation, the governing equations of the drug release system in Python and the numerical solution method were utilized to determine the drug release mechanism in the hydrogel. Then, the graphs of the changes in drug concentration in each hydrogel were examined to evaluate the performance of hydrogels in drug release. Observations revealed that the swelling rate of the hydrogel increases as the concentration of chitosan relative to gelatin in the hydrogel composition rises and that the drug release rate in hydrogels with more significant swelling was also accelerated. Compared to Cs-Gel (1:4) hydrogel, the drug release time in Cs-Gel (4:1), Cs-Gel (3:2), Cs-Gel (2.5:2.5) and Cs-Gel (2:3) hydrogels decreased by 52, 44, 37, and 18%, respectively. In hydrogels with a high swelling rate, the drug concentration decreased rapidly, whereas in hydrogels with a low swelling rate, the duration of drug release increased. This is due to the significance of mass transfer via mass movement and inflation rate.

منابع و مأخذ:

1. Rungrod A., Kapanya A., Punyodom W., Molloy R., Mahomed A., Somsunan R., 2022. Synthesis and characterization of semi-IPN hydrogels composed of sodium 2-acrylamido-2-methylpropanesulfonate and poly (ε-caprolactone) diol for controlled drug delivery. European Polymer Journal.164, 110978.


2. Akbarzadeh M., Vardini M. T., Mahdavinia G. R., 2018. Preparation of a novel magnetic nanocomposite hydrogel based on carboxymethyl chitosan for the adsorption of crystal violet as cationic dye. Journal of Chemical Health Risks. 8(4), 289-304.


3. Noshad M., Hojjati M., Hassanzadeh M., Zadeh-Dabbagh R., HosseinKhani M., 2022. Edible Utilization of Xanthan-guar Oleogels as a Shortening Replacement in Sponge Cake: Physicochemical Properties. Journal of Chemical Health Risks.12(2), 255-264.


4. Whitehead F.A., Kasapis S., 2022. Modelling the mechanism and kinetics of ascorbic acid diffusion in genipin-crosslinked gelatin and chitosan networks at distinct pH. Food Bioscience. 46, 101579.


5. Mirzababaei M., Larijani K., Hashemi-Moghaddam H., Mirjafary Z., Madanchi H., 2022. Graphene quantum dots coated cationic polymer for targeted drug delivery and imaging of breast cancer. Research Squar. https://doi.org/10.21203/rs.3.rs-1740614/v1


6. Farhad-Gholami N., Hashemi-Moghaddam H., Shaabanzadeh M., Zavareh S., Madanchi H., 2021. Sustained doxorubicin delivery system to breast tumor cancer cell based on a novel cationic molecularly imprinted polymer. International Journal of Polymeric Materials and Polymeric Biomaterials. 1-10.


7. Naghaviyan A., Hashemi-Moghaddam H., Zavareh S., Ebrahimi Verkiani M., Meuller A., 2022. Synergistic Effect Evaluation of Magnetotherapy and a Cationic–Magnetic Nanocomposite Loaded with Doxorubicin for Targeted Drug Delivery to Breast Adenocarcinoma. Molecular pharmaceutics. 20(1), 101-117.


8. Hashemi‐Moghaddam H., Ebrahimi M., Johari B., Madanchi H., 2021. Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 109(10), 1578-1587.


9. Bacaita E., Ciobanu B., Popa M., Agop M., Desbrieres J., 2014. Phases in the temporal multiscale evolution of the drug release mechanism in IPN-type chitosan based hydrogels. Physical Chemistry Chemical Physics. 16(47), 25896-25905.


10. Xu Y., Liu J., Guan S., Cao Y., Chen C., Wang D., 2020. A dual pH and redox-responsive Ag/AgO/carboxymethyl chitosan composite hydrogel for controlled dual drug delivery. Journal of Biomaterials science, Polymer Edition. 31(13), 1706-1721.


11. Rahmanian-Devin P., Baradaran Rahimi V., Askari V. R., 2021. Thermosensitive chitosan-β-glycerophosphate hydrogels as targeted drug delivery systems: An overview on preparation and their applications. Advances in Pharmacological and Pharmaceutical Sciences. 2021, 1-17.


12. Rafique N., Ahmad M., Minhas M.U., Badshah S.F., Malik N.S., Khan K.U., 2022. Designing gelatin-based swellable hydrogels system for controlled delivery of salbutamol sulphate: Characterization and toxicity evaluation. Polymer Bulletin. 79(7), 4535-4561.


13. Jacob S., Nair A.B., Shah J., Sreeharsha N., Gupta S., Shinu P., 2021. Emerging role of hydrogels in drug delivery systems, tissue engineering and wound management. Pharmaceutics. 13(3), 357.


14. Askari E., Seyfoori A., Amereh M., Gharaie S.S., Ghazali H.S., Ghazali Z.S., Khunjush B., Akbari M., 2020. Stimuli-responsive hydrogels for local post-surgical drug delivery. Gels. 6(2), 14.


15. Zhang S., Kang L., Hu S., Hu J., Fu Y., Hu Y., Yang X., 2021. Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease. International Journal of Biological Macromolecules. 167, 1598-1612.


16. Khan H., Shukla R., Bajpai A., 2016. Genipin-modified gelatin nanocarriers as swelling controlled drug delivery system for in vitro release of cytarabine. Materials Science and Engineering: C. 61, 457-465.


17. Ngwabebhoh F.A., Zandraa O., Patwa R., Saha N., Capáková Z., Saha P., 2021. Self-crosslinked chitosan/dialdehyde xanthan gum blended hypromellose hydrogel for the controlled delivery of ampicillin, minocycline and rifampicin. International Journal of Biological Macromolecules. 167, 1468-1478.


18. Qu R., Zhang W., Liu N., Zhang Q., Liu Y., Li X., Wei Y., Feng L., 2018. Antioil Ag₃PO₄ nanoparticle/polydopamine/Al₂O₃ sandwich structure for complex wastewater treatment: dynamic catalysis under natural light. ACS Sustainable Chemistry & Engineering. 6(6), 8019-8028.


19. Chilin C., Metters A., 2006. Hydrogels in controlled release formulations: Network design and mathematical modelling. Adv Drug Deliv Rev. 58, 1379-1408.


20. Bhattarai N., Gunn J., Zhang M., 2010. Chitosan-based hydrogels for controlled, localized drug delivery. Advanced Drug Delivery Reviews. 62(1), 83-99.


21. Yu Y., Xu S., Li S., Pan H., 2021. Genipin-cross-linked hydrogels based on biomaterials for drug delivery: A review. Biomaterials Science. 9(5), 1583-1597.


22. Ren Y., Zhao X., Liang X., Ma P. X., Guo B., 2017. Injectable hydrogel based on quaternized chitosan, gelatin and dopamine as localized drug delivery system to treat Parkinson’s disease. International Journal of Biological Macromolecules. 105, 1079-1087.


23. Fonseca-Santos B., Chorilli M., 2017. An overview of carboxymethyl derivatives of chitosan: Their use as biomaterials and drug delivery systems. Materials Science and Engineering: C. 77, 1349-1362.


24. Javanbakht S., Shadi M., Mohammadian R., Shaabani A., Amini M.M., Pooresmaeil M., Salehi R., 2019. Facile preparation of pH-responsive k-Carrageenan/tramadol loaded UiO-66 bio-nanocomposite hydrogel beads as a nontoxic oral delivery vehicle. Journal of Drug Delivery Science and Technology. 54, 101311.


25. Chen Y., Qiu Y., Wang Q., Li D., Hussain T., Ke H., Wei Q., 2020. Mussel-inspired sandwich-like nanofibers/hydrogel composite with super adhesive, sustained drug release and anti-infection capacity. Chemical Engineering Journal. 399, 125668.


26. Islam A., Riaz M., Yasin T., 2013. Structural and viscoelastic properties of chitosan-based hydrogel and its drug delivery application. International Journal of Biological Macromolecules. 59, 119-124.


27. Song Y., Nagai N., Saijo S., Kaji H., Nishizawa M., Abe T., 2018. In situ formation of injectable chitosan-gelatin hydrogels through double crosslinking for sustained intraocular drug delivery. Materials Science and Engineering: C. 88, 1-12.


28. Caccavo D., 2019. An overview on the mathematical modeling of hydrogels’ behavior for drug delivery systems. International Journal of Pharmaceutics. 560, 175-190.


29. Ubaid M., Murtaza G., 2018. Fabrication and characterization of genipin cross-linked chitosan/gelatin hydrogel for pH-sensitive, oral delivery of metformin with an application of response surface methodology. International Journal of Biological Macromolecules. 114, 1174-1185.


30. Chen S.C., Wu Y.C., Mi F.L., Lin Y.H., Yu L.C., Sung H.W., 2004. A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. Journal of Controlled Release. 96(2), 285-300.


31. Haroun A.A., El-Halawany N., 2010. Encapsulation of bovine serum albumin within β-cyclodextrin/gelatin-based polymeric hydrogel for controlled protein drug release. Irbm. 31(4), 234-241.


32. Islam A., Yasin T., 2012. Controlled delivery of drug from pH sensitive chitosan/poly (vinyl alcohol) blend. Carbohydrate Polymers. 88(3), 1055-1060.


33. Patel S., Srivastava S., Singh M. R., Singh D., 2018. Preparation and optimization of chitosan-gelatin films for sustained delivery of lupeol for wound healing. International Journal of Biological Macromolecules. 107, 1888-1897.