Ethanol Consumption Promotes TNF-α Signaling Pathway in Rat Kidney: Rescue Effect of Curcumin
محورهای موضوعی :
Amin Abdollahzade Fard
1
(Nephrology and Kidney Transplant Research Center, Clinical Research Institute,Urmia University of Medical Sciences , Urmia , Iran)
Mahrokh Samadi
2
(Nephrology and Kidney Transplant Research Center, Clinical Research Institute,Urmia University of Medical Sciences , Urmia , Iran)
Alireza Shirpoor
3
(Nephrology and Kidney Transplant Research Center, Clinical Research Institute,Urmia University of Medical Sciences , Urmia , Iran|Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran)
Yousef Rasmi
4
(Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran)
کلید واژه: Curcumin, ethanol, TNF-α, TNFR-1, RIP-1, NFқB,
چکیده مقاله :
Tumor necrosis factor-α (TNFα) has several biological effects, including cell death, cell apoptosis and proliferation, and differentiation, as well as immune modulation. We characterized the alteration in TNF-α and the key receptors and molecular mediators related to TNF-α signaling pathway in the kidney after exposure to ethanol alone or in combination with curcumin (Cr). Accordingly, 24 male Wistar rats in 3 groups of control, ethanol, and Cr-treated - ethanolic groups were treated for six weeks. The ethanol group showed a significant elevation in TNF-α, nuclear factor-κB (NF-κB), and endothelin 1 (ET1) than the control group. TNF-α receptor 1 (TNFR1), TNF-α receptor 2 (TNFR2) and vascular endothelial growth factor receptor 2 (VEGFR2) were found with a significant down-regulation, and of TNF-receptor-associated factor 2 (TRAF2) and receptor-interacting protein-1 (RIP-1), and activator protein-1 (AP-1) were found with an up-regulation in the ethanol group than the control group. Cr and ethanol decreased the gene expression of TRAF-2, RIP-1 and AP-1, as well as increased the gene expression of TNFR1. Cr administration restored the increased levels of TNF-α, NF-κB and endothelin to these levels in the control group. Therefore, ethanol-related kidney injury addressed by our previous studies and others may in part be associated with the TNF-α signaling pathway, and such impacts can be rescued by Cr as an antioxidant and anti-inflammatory compound.
1. Latchoumycandane C., Hanouneh M., Nagy L.E. McIntyre T.M., 2015. Inflammatory PAF receptor signaling initiates hedgehog signaling and kidney fibrogenesis during ethanol consumption. PloS one. 10, e0145691.
2. Shirpoor A., Norouzi L., Ansari M.H.K., Ilkhanizadeh B., Gharaaghaji R., 2013. Vasoprotective effect of vitamin E: rescue of ethanol-induced atherosclerosis and inflammatory stress in rat vascular wall. International immunopharmacology. 16, 498-504.
3. Latchoumycandane C., Nagy L.E., McIntyre T.M., 2014. Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation. Free Radical Biology and Medicine. 69, 403-16.
4. Vassalli P., 1992. The pathophysiology of tumor necrosis factors. Annual Review of Immunology. 10, 411-52.
5. Richter C., Messerschmidt S., Holeiter G., Tepperink J., Osswald S., Zappe A., Branschädel M., Boschert V., Mann D.A., Scheurich P., 2012. The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand. Molecular and Cellular Biology. 32, 2515-29.
6. Rosa A.C., Rattazzi L., Miglio G., Collino M., Fantozzi R., 2012. Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes. Inflammation Research. 61, 311-17.
7. Baud L., Oudinet J.P., Bens M., Noe L., Peraldi M.N., Rondeau E., Etienne J., Ardaillou R., 1989. Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide. Kidney International. 35, 1111-18.
8. Zager R., Johnson A.C., Hanson S.Y., Lund S., 2005. Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-α generation and systemic release. American Journal of Physiology-Renal Physiology. 289, F289-F97.
9. Lin Y., Devin A., Rodriguez Y. Liu Z.G., 1999. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes & Development. 13, 2514-26.
10. Arch R.H., Gedrich R.W., Thompson C.B., 1998. Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death. Genes & Development. 12, 2821-30.
11. Vallabhapurapu S., Karin M., 2009. Regulation and function of NF-κB transcription factors in the immune system. Annual Review of Immunology. 27, 693-733.
12. Hayden M.S., Ghosh S., 2012. NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes & Development. 26, 203-34.
13. Tak P.P., Firestein G.S., 2001. NF-κB: a key role in inflammatory diseases. The Journal of Clinical Investigation. 107, 7-11.
14. Donnahoo K.K., Shames B.D., Harken A.H., Meldrum D.R., 1999. The role of tumor necrosis factor in renal ischemia-reperfusion injury. The Journal of Urology. 162, 196-203.
15. Ruiz-Ortega M., Ruperez M., Lorenzo O., Esteban V., Blanco J., Mezzano S., Egido J., 2002. Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney International. 62, S12-S22.
16. Zhang H., Sun S.C., 2015. NF-κB in inflammation and renal diseases. Cell & Bioscience. 5, 1-12.
17. Shirpoor A., Rezaei F., Fard A.A., Afshari A.T., Gharalari F.H., Rasmi Y., 2016. Ginger extract protects rat’s kidneys against oxidative damage after chronic ethanol administration. Biomedicine & Pharmacotherapy. 84, 698-704.
18. Ding R.B., Tian K., He C.W., Jiang Y., Wang Y.T., Wan J.B., 2012. Herbal medicines for the prevention of alcoholic liver disease: a review. Journal of Ethnopharmacology. 144, 457-65.
19. Najafi H., Ashtiyani S.C., Sayedzadeh S.A., 2015. Therapeutic effects of curcumin on the functional disturbances and oxidative stress induced by renal ischemia/reperfusion in rats. Avicenna Journal of Phytomedicine. 5, 576-586.
20. Mahmoud A.M., Ahmed O.M., Galaly S.R., 2014. Thymoquinone and curcumin attenuate gentamicin-induced renal oxidative stress, inflammation and apoptosis in rats. EXCLI Journal. 13, 98-110.
21. Gupta S.C., Patchva S., Koh W., Aggarwal B.B., 2012. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clinical and Experimental Pharmacology and Physiology. 39, 283-99.
22. Fujisawa S., Atsumi T., Ishihara M., Kadoma Y., 2004. Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds. Anticancer Research. 24, 563-70.
23. Huang J., Huang K., Lan T., Xie X., Shen X., Liu P., Huang H., 2013. Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway. Mol Cell Endocrinol. 365, 231-40.
24. Samadi M., Shirpoor A., Afshari A.T., Kheradmand F., Rasmi Y., Sadeghzadeh M., 2018. Chronic ethanol ingestion induces glomerular filtration barrier proteins genes expression alteration and increases matrix metalloproteinases activity in the kidney of rats. Interventional Medicine and Applied Science. 10, 171-77.
25. Wu T., Marakkath B., Ye Y., Khobahy E., Yan M., Hutcheson J., Zhu J., Zhou X. Mohan C. 2020. Curcumin Attenuates Both Acute and Chronic Immune Nephritis. International Journal of Molecular Sciences. 21, 1745-1761.
26. Shao-Ling W., Ying L., Ying W., Yan-Feng C., Li-Xin N., Song-Tao L., Chang-Hao S., 2009. Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomedical and Environmental Sciences. 22, 32-39.
27. Zhang J., Tang L., Li G.S., Wang J., 2018. The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats. Renal Failure. 40, 680-86.
28. Baud V., Karin M., 2001. Signal transduction by tumor necrosis factor and its relatives. Trends in Cell Biology. 11, 372-77.
29. Zhu L., Yang X., Ji Y., Chen W., Guan W., Zhou S., Yu X., 2009. Up-regulated renal expression of TNF-α signalling adapter proteins in lupus glomerulonephritis. Lupus. 18, 116-27.
30. Navarro J.F., Mora-Fernández C., 2006. The role of TNF-α in diabetic nephropathy: pathogenic and therapeutic implications. Cytokine & Growth Factor Reviews. 17, 441-50.
31. Ernandez T., Mayadas T., 2009. Immunoregulatory role of TNFα in inflammatory kidney diseases. Kidney International. 76, 262-76.
32. Prescott S.M., McIntyre T.M., Zimmerman G.A., Stafforini D.M., 2002. Sol Sherry lecture in thrombosis: molecular events in acute inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 22, 727-33.
33. Gloire G., Legrand-Poels S., Piette J., 2006. NF-κB activation by reactive oxygen species: fifteen years later. Biochemical Pharmacology. 72, 1493-505.
34. Oliver K.M., Taylor C.T., Cummins E.P., 2009. Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases. Arthritis Research & Therapy. 11, 215-223.
35. Darnay B.G., Aggarwal B.B., 1997. Early events in TNF signaling: a story of associations and dissociations. Journal of Leukocyte Biology. 61, 559-66.
36. Al-Lamki R.S., Mayadas T.N., 2015. TNF receptors: signaling pathways and contribution to renal dysfunction. Kidney International. 87, 281-96.
37. Gohda T., Niewczas M.A., Ficociello L.H., Walker W.H., Skupien J., Rosetti F., Cullere X., Johnson A.C., Crabtree G., Smiles A.M., 2012. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. Journal of the American Society of Nephrology. 23, 516-24.
38. Sun S.C., 2011. Non-canonical NF-κB signaling pathway. Cell Research. 21, 71-85.
39. Lo J.Y., Kamarudin M.N.A., Hamdi O.A.A., Awang K., Kadir H.A., 2015. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food & Function. 6, 3550-59.
40. Yu Y., Shen Q., Lai Y., Park S.Y., Ou X., Lin D., Jin M., Zhang W., 2018. Anti-inflammatory effects of curcumin in microglial cells. Frontiers in Pharmacology. 9, 386-396.
41. Zhang R., Xu Y., Ekman N., Wu Z., Wu J., Alitalo K., Min W., 2003. Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway. Journal of Biological Chemistry. 278, 51267-76.
42. Fu Z., Chen X., Guan S., Yan Y., Lin H., Hua Z.C., 2015. Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway. Oncotarget. 6, 19469-19482.
43.Bagnato A., Spinella F., 2003. Emerging role of endothelin-1 in tumor angiogenesis. Trends in Endocrinology & Metabolism. 14, 44-50.
