Lactobacillus paracasei Impact on Myocardial Hypertrophy in Rats with Heart Failure
محورهای موضوعی :
Zohreh Hesari
1
(Department of Pathobiology, School of Veterinary Medicine, Semnan University, Semnan, Iran)
Khatereh Kafshdoozan
2
(Department of Pathobiology, School of Veterinary Medicine, Semnan University, Semnan, Iran)
Mahdi Barati
3
(Department of Immunology, Mashhad University of Medical Sciences, Mashhad, Iran)
Parviz Kokhaei
4
(Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran)
Sina Andalib
5
(Department of Pharmacology, Zanjan University of Medical Sciences, Zanjan, Iran)
Fatemeh TalebiKiassari
6
(Student Research Committee, Iran University of Medical Sciences, Tehran, Iran)
Mahboubeh Darban
7
(School of Medicine, Semnan University of Medical Sciences, Semnan, Iran)
anna abdolshahi
8
(Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran)
Bahador Bagheri
9
(Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran)
کلید واژه: Rat, Heart failure, Lactobacillus, Chemerin, Atrial Natriuretic Peptide,
چکیده مقاله :
Cardiac hypertrophy and cardiac dysfunction are important complications of heart failure. Cardiovascular, immunological, and hormonal players are involved in the pathogenesis of heart failure. Current evidence suggests that probiotics may have fruitful effects on the heart function. This was our aim. To this end, effects of oral administration of Lactobacillus paracasei subsp. paracasei 8700:2 on isoproterenol-induced heart failure were investigated. Forty male Wistar rats weighing 200 g were randomly assigned to five groups; the control group (saline-treated group), probiotic-treated group, heart failure group (isoproterenol-introduced group), pretreatment group (treating them by probiotic for 20 days then induced heart failure) and treatment group (following heart failure-induced, treating them by probiotic for 20 days). The groups were studied for 30 days. Serum levels of atrial natriuretic peptide (ANP) and chemerin were measured by ELISA. Finally, the hearts were removed for histopathological evaluation. Compared to the control group, isoproterenol caused cardiac hypertrophy and increased ANP (P < 0.05) and chemerin levels. Treatment with Lactobacillus paracasei significantly reduced the levels of ANP (P < 0.01) and decreased the pathological damages to the myocardium. It caused a small reduction in chemerin level, as well. Pretreatment with probiotics had no positive effects on cardiac hypertrophy and related parameters. Our findings indicate that treatment with Lactobacillus paracasei subsp. paracasei 8700:2 reduces cardiac hypertrophy in rats. In addition, this probiotic reduces the serum levels of chemerin and ANP.
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