Synthesis of a carbon-14 analogue of N-(aryl-methyl)-3-phenyl-acryl amidine-[carboxy-14C] and its derivatives as NR2B-selective NMDA receptor antagonist
محورهای موضوعی : Journal of the Iranian Chemical Research
Nader Saemian
1
(Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research
Institute, Tehran, P.O. Box: 11365-3486, Iran)
Kameh Esmailli
2
(Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research
Institute, Tehran, P.O. Box: 11365-3486, Iran)
Gholamhossein Shirvani
3
(Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research
Institute, Tehran, P.O. Box: 11365-3486, Iran)
Mohsen Javaheri
4
(Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research
Institute, Tehran, P.O. Box: 11365-3486, Iran)
Omid Khalili Arjomandi
5
(Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research
Institute, Tehran, P.O. Box: 11365-3486, Iran)
کلید واژه: NMDA-receptor, Carbon-14, Labeling, Amidines,
چکیده مقاله :
Four amidine NR2B-selective NMDA receptor antagonists, N-( 2-methoxy benzyl) -3-phenyl-acrylamidine, N-[diduterio(2-methoxyphenyl) methyl]-3-phenyl-acrylamidine, N-benzyl-3-phenyl-acryl amidine and N-[diduterio(phenyl)methyl]-3-phenyl-acrylamidine, all fourlabeled with carbon-14 in the 1-position, have been synthesized as part of 5-step sequence fromBa14CO3.
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