Sequential calculation of torque in procedure of twin screw extrusion
محورهای موضوعی : Smart & Advanced Materialsمحمد فرید خان سمنی 1 , امیر حسین زمان پور نیاوران 2 , مصیب جعفرنود 3
1 - Islamic Azad university south Tehran branch
2 - South Tehran Branch, Islamic Azad University, Tehran, Iran
3 - South Tehran Branch, Islamic Azad University, Tehran, Iran
کلید واژه: twin screw extrusion, bioavailibility,
چکیده مقاله :
The drug making resreach has accentuated on extrusion technology for a long time. The advance of drug bioavailibility, bead manufacturing and granulation is assured by extrusion procedures. There are also diverse effects in resereches with respect to the use of process understanging as a tool in quality management. Many initiatives of FDA such as PAT and QBD are getting accepted. In this survey a corotating twin-screw extruder was facilitated with a torque gauge as a tool to monitor the process. The experimental arrangements were qualified based on the ICH instructions. The extrusion torque has a relation with the water content in a wet extrusion process. Besides, a process of pelletisation was done utilizing various formulations in wet spheronization. There found the relationship between the torque on the screws and the form of the pellet. In a nutshell, the torque proved to be a very good extrusion criteria for monitoring processes of wet extrusion
[1] M.M. Crowley, F. Zhang, M.A. Repka, S. Thumma, S.B. Upadhye, S. Kumar Battu, J.W. McGinity, C. Martin, Pharmaceutical applications of hot-melt extrusion: part I, Drug development and industrial pharmacy, 33 (2007) 909-926.
[2] A. Dukić-Ott, M. Thommes, J.P. Remon, P. Kleinebudde, C. Vervaet, Production of pellets via extrusion–spheronisation without the incorporation of microcrystalline cellulose: a critical review, European journal of pharmaceutics and biopharmaceutics, 71 (2009) 38-46.
[3] D. Djuric, P. Kleinebudde, Impact of screw elements on continuous granulation with a [1] M.M. Crowley, F. Zhang, M.A. Repka, S. Thumma, S.B. Upadhye, S. Kumar Battu, J.W. McGinity, C. Martin, Pharmaceutical applications of hot-melt extrusion: part I, Drug development and industrial pharmacy, 33 (2007) 909-926.
[2] A. Dukić-Ott, M. Thommes, J.P. Remon, P. Kleinebudde, C. Vervaet, Production of pellets via extrusion–spheronisation without the incorporation of microcrystalline cellulose: a critical review, European journal of pharmaceutics and biopharmaceutics, 71 (2009) 38-46.
[3] D. Djuric, P. Kleinebudde, Impact of screw elements on continuous granulation with a twin‐screw extruder, Journal of pharmaceutical sciences, 97 (2008) 4934-4942.
[4] I. Ghebre-Selassie, C. Martin, Pharmaceutical extrusion technology, CRC Press, 2003.
[5] FDA, Guidance for Industry PAT: A Framework for Innovative Pharmaceutical Development, Manufacuring, and Quality Assurance, FDA official document, (2004) 16.
