Nanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction
محورهای موضوعی : Iranian Journal of CatalysisFarhad Shirini 1 , Seyyed Vahid Atghia 2 , Meysam Alipour Khoshdel 3
1 - Department of Chemistry, College of Science, University of Guilan, Rasht, zip code 41335, I.R. Iran.
2 - Department of Chemistry, College of Science, University of Guilan, Rasht, zip code 41335, I.R. Iran.
3 - Department of Chemistry, College of Science, University of Guilan, Rasht, zip code 41335, I.R. Iran.
کلید واژه: Heterogeneous catalysis, Nanocrystalline TiO2, Hantzsch reaction, Polyhydorquinolie derivatives, one-pot condensation reaction,
چکیده مقاله :
An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages such as heterogeneous catalysis, simple work-up procedure, recyclability of the catalyst and purification of products without chromatographic methods.
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