Antioxidant activity of the extracts from Salvia officinalis, Brassica oleracea, Juglans regia, Melilotus officinalis, and Crataegus oxyacantha at different temperatures
محورهای موضوعی : مجله گیاهان داروییمحمد مؤمن هروی 1 , شهلا دانش مهر 2 , علی مرسلی 3
1 - گروه شیمی فیزیک، دانشگاه آزاد اسلامی واحد مشهد، مشهد، ایران
2 - گروه شیمی فیزیک، دانشگاه آزاد اسلامی واحد مشهد، مشهد، ایران
3 - گروه شیمی فیزیک، دانشگاه آزاد اسلامی واحد مشهد، مشهد، ایران
کلید واژه: cancer, Medicinal plant, Free radical, Scavenging Activity,
چکیده مقاله :
Background & Aim: Medicinal plants can be a good replacement for common cancer treatment including chemotherapy, radiation therapy and surgery because they don’t have many side effects. The aim of this study was to investigate the effect of temperature on the free radical scavenging in the presence of medicinal plants.Experimental: For determination of free radical scavenging activity was used the stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay at different temperatures. Ethanolic extracts of Sage (Salvia officinalis), red cabbage (Brassica oleracea), walnut (Juglans regia L.), yellow sweet clover (Melilotus officinalis) and hawthorn (Crataegus oxyacantha) one by one and then the mixtures of each pair of plants were investigated.Results: The most free radical scavenging percentages are related to plants in single forms not mixtures. The results demonstrated that with increasing temperature, free radical scavenging increased in the presence of sage, while it decreased in the presence of hawthorn. The highest free radical scavenging percentages at temperatures ranging from ambient to body and fever are related to sage at 25˚C, and then walnut leaves at 37˚C and finally, hawthorn at 40˚C.Recommended applications/industries: The results indicated that for preventing herb-herb interactions, medicinal plants as tea, food and fruit are used alone.
مقدمه و هدف: گیاهان دارویی بدلیل نداشتن اثرات جانبی بسیار، می توانند جایگزین خوبی برای روش های مرسوم درمان سرطان شامل شیمی درمانی،پرتو درمانی و جراحی باشند. هدف از این مطالعه بررسی تاثیر دما در مهار رادیکال آزاد در دماهای مختلف می باشد. روش تحقیق:برای تعیین فعالیت مهار کنندگی رادیکال آزاد با استفاده از عیارسنجی DPPH در دماهای مختلف دو تحقیق انجام شده است: ابتدا عصاره اتانولی مریم گلی، کلم قرمز، برگ گردو، اکلیل الملک و زالزالک به تنهایی و سپس مخلوط دوتایی از هر گیاه به منظور تعیین بر هم کنش های گیاه- گیاه. نتایج و بحث: به دلیل برهم کنش های گیاه- گیاه ، بیشترین در صد مهار رادیکال آزاد مربوط گیاهان به صورت تکی می باشد نه مخلوط. نتایج نشان دادند که با افزایش دما مهار رادیکال آزاد در حضور مریم گلی افزایش می یابد، در حالیکه در حضور زالزالک کاهش می یابد. بالاترین درصد مهار رادیکال آزاد در محدوده دمایی بین محیط تا دمای بدن وتب مربوط به مریم گلی در ˚C25 و بعد از آن مربوط به برگ گردو در˚C37 و در آخر زالزالک در ˚C40 می باشد. توصیه کاربردی/ صنعتی:نتایج دلالت دارند که بر جلوگیری از اثرات تداخلی (برهم کنش های گیاه- گیاه)، گیاهان دارویی به صورت دمنوش، غذا و میوه به تنهایی مصرف شوند.
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