List of Articles tamsulosin

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  1 - Evaluation of the Protective Effects of the Hydroalcoholic Extract of Securigera Securidaca L. Seeds on Alterations of Serum Biochemical Parameters and Renal Indices in Tamsulosin-Treated Male Rats
  Sadigheh Khezri Motlagh Mokhtar Mokhtari Mehrdad Shariati
  10.22034/ascij.2022.1963966.1405
  Securigera securidaca L. seeds are rich in polyphenols and flavonoids that have many biological effects. The aim of this study was to evaluate the protective effects of hydroalcoholic extract of Securigera securidaca seed on alterations in serum biochemical parameters i More

  Securigera securidaca L. seeds are rich in polyphenols and flavonoids that have many biological effects. The aim of this study was to evaluate the protective effects of hydroalcoholic extract of Securigera securidaca seed on alterations in serum biochemical parameters including glucose, lipid profile (cholesterol, triglyceride, LDL and HDL), renal function indices (creatinine and BUN) and antioxidant enzymes activity (Catalase, superoxide dismutase, and glutathione peroxidase) in tamsulosin-treated male rats. Seventy-two adult male rats were grouped into 9 groups of 8. The control group did not receive drug treatment but the sham group received 1 ml of extract solvent, the positive control group received 0.4 mg/kg Tamsulosin, negative control groups 1, 2, and 3 received 200, 400, and 800 mg/kg extract, respectively and experimental groups 1, 2 and 3 first received 0.4 mg/kg Tamsulosin and then 200, 400 and 800 mg/kg of extract for 28 days, respectively. Finally, blood samples were collected to measure the serum biochemical parameters. Tamsulosin increased the levels of glucose, creatinine and BUN, and decreased the level of antioxidant enzymes activity in the control group (p < 0.05), but did not cause significant changes in the level of lipid profile (p > 0.05). However, treatment with doses of 400 and 800 mg/kg of extract in experimental groups 2 and 3, improved glucose, creatinine, BUN and antioxidant enzymes activity compared to the control group (p < 0.05). Hydroalcoholic extract of Securigera securidaca seeds can improve changes in biochemical parameters and renal function indices in the serum of tamsulosin-treated male rats. Manuscript profile
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  2 - The effect of Tamsulosin with or without Tolterodine in treatment of patients with symptomatic BPH in Aria and 22 Bahman hospital in 2012
  Masoud Isapour Mahsa Abdollahian Moghadam
  Background: Although voiding symptoms are classically related to BPH, as many as 50% of patients can experience irritative symptoms. We compared efficacy of tamsulosin with or without tolterodine in the treatment of patients with symptomatic  BPH (benign prostatic More

  Background: Although voiding symptoms are classically related to BPH, as many as 50% of patients can experience irritative symptoms. We compared efficacy of tamsulosin with or without tolterodine in the treatment of patients with symptomatic  BPH (benign prostatic hyperplasia). Methods: seventy six patients who fulfilled the inclusion/ exclusion criteria were randomly divided into two groups of tamsulosin monotherapy (0/4 mg/day until 12 weeks) versus tamsulosin (0/4 mg/day until 12 weeks) and Tolterodine (2mg BID for 4 weeks) combination therapy. Therapeutic efficacy was analyzed using international prostate symptom score (IPSS) before and after 4 weeks of treatment. Results: Total IPSS was significantly improved in both groups. Although Combination therapy group showed better improvement in all Lower urinary tract symptoms, but the difference between 2 groups was significant considering complete emptying of bladder, voiding duration less than 2 hours and weak stream (P<0/05). Conclusion: Addition of Tolterodin to Tamsulosin is effective in improving lower urinary tract symptoms in patients with benign prostatic hyperplasia.   Manuscript profile